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Magnetite Nanocomposites Thin Coatings Prepared by MAPLE to Prevent Microbial Colonization of Medical Surfaces

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Book cover Eco-friendly Polymer Nanocomposites

Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 74))

Abstract

MAPLE (matrix-assisted pulsed laser evaporation) technique revealed a significant relevance in the deposition of bioactive nanostructures on different surfaces for the prevention and/or treatment of microbial infections associated with medical devices. Recent research progress highlights the development of two new directions for biomedical applications of magnetite nanoparticles: the antimicrobial therapy and microbial virulence and biofilm modulation. The aim of this chapter is to highlight the usefulness of functionalized magnetite nanoparticles as efficient anti-infective agents. In this respect, different type of nanocomposites based on hydrophilic/hydrophobic polymers and iron oxide nanostructures combined with natural and synthetic therapeutic agents are discussed. We offer a wide perspective regarding their synthesis, characterization, biocompatibility, and the ability to modulate the microbial attachment and biofilms development on different type of prosthetic devices or metal implants. All reported data demonstrate that magnetite-based bioactive coatings significantly inhibit the microbial colonization on the coated medical surfaces, features that together with their high in vivo viability recommend these type of thin coatings for the development of anti-infective surfaces for biomedical applications.

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Acknowledgments

The work has been funded by the Sectoral Operational Programme Human 687 Resources Development 2007–2013 of the Ministry of European Funds through the Financial 688 Agreement P

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Authors and Affiliations

  1. Faculty of Biology, Microbiology Department, University of Bucharest, Aleea Portocalelor no 1-3, 060101, Bucharest, Romania

    Alina Maria Holban & Crina Maria Saviuc

  2. Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, Polizu Street no 1-7, 011061, Bucharest, Romania

    Alina Maria Holban & Alexandru Mihai Grumezescu

  3. Biotehnos S.A, Otopeni, Romania

    Crina Maria Saviuc

Authors
  1. Alina Maria Holban
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  2. Alexandru Mihai Grumezescu
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  3. Crina Maria Saviuc
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Correspondence to Alexandru Mihai Grumezescu .

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Editors and Affiliations

  1. Mechanical and Materials Engineering, Washington State University, Pullman, Washington, USA

    Vijay Kumar Thakur

  2. Chemistry, Himachal Pradesh University, Shimla, Himachal Pradesh, India

    Manju Kumari Thakur

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Holban, A.M., Grumezescu, A.M., Saviuc, C.M. (2015). Magnetite Nanocomposites Thin Coatings Prepared by MAPLE to Prevent Microbial Colonization of Medical Surfaces. In: Thakur, V., Thakur, M. (eds) Eco-friendly Polymer Nanocomposites. Advanced Structured Materials, vol 74. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2473-0_10

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