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Small Molecule Osmolytes Can Modulate Proteostasis

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Proteostasis and Chaperone Surveillance

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Abstract

Organisms are subjected to several harsh extreme environmental conditions and stresses that normally hamper growth and their physiological function. In response, nature has developed certain mechanisms to counteract these extreme stress conditions and one such mechanism is the accumulation of certain small molecular weight organic solutes called osmolytes. These osmolytes protect intracellular proteins and other macromolecules against the deleterious effects induced by these stress conditions. In addition to these protecting roles of these solutes against stress, they have also been shown to correct protein misfolding, relieve aggregation and amyloidogenic progression in various proteopathies related proteins. The present chapter discusses the significant advances made in the field of mechanisms of the osmolytes-induced protein folding/stabilization. The chapter has been designed so as to include all aspects of osmolytes actions on proteins stability and functions. Later sections also highlight the possible use of these organic osmolytes as pharmaceutical drugs in preventing aggregation/amyloidogenesis related human diseases.

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Authors and Affiliations

  1. Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, 110 007, India

    Gurumayum Suraj Sharma, Marina Warepam & Laishram Rajendrakumar Singh

  2. Department of Clinical Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, 190006, India

    Tanveer Ali Dar

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  1. Gurumayum Suraj Sharma
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  2. Marina Warepam
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  3. Laishram Rajendrakumar Singh
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  4. Tanveer Ali Dar
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Correspondence to Tanveer Ali Dar .

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Editors and Affiliations

  1. Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, New Delhi, Delhi, India

    Laishram Rajendrakumar Singh

  2. Clinical Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Tanveer Ali Dar

  3. Department of Botany, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Parvaiz Ahmad

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Sharma, G.S., Warepam, M., Singh, L.R., Dar, T.A. (2015). Small Molecule Osmolytes Can Modulate Proteostasis. In: Singh, L.R., Dar, T.A., Ahmad, P. (eds) Proteostasis and Chaperone Surveillance. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2467-9_3

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