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Anaplastic Thyroid Cancer: Current Concepts

  • Sylvie Galindo
  • Sam M. Wiseman
Part of the Head and Neck Cancer Clinics book series (HNCC)

Abstract

Anaplastic thyroid cancer (ATC) is a rare and aggressive malignancy with an extremely poor prognosis compared to other types of thyroid cancer. Survival rates for ATC are dependent on the extent of disease at diagnosis, and many patients present with locally advanced or metastatic disease. Strong evidence suggests that ATC develops from pre-existing differentiated thyroid cancer (DTC) through a post-malignant cancer progression or anaplastic transformation. Current treatments are multimodal and offer little hope for a cure. Unfortunately, ATC has remained a highly lethal malignancy. ATCs possess genetic and molecular derangements that could be targeted by novel therapies in the future.

Keywords

Epidermal Growth Factor Receptor Thyroid Cancer Differentiate Thyroid Cancer Medullary Thyroid Cancer Anaplastic Thyroid Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© K. Alok Pathak, Richard W. Nason, Janice L. Pasieka, Rehan Kazi, Raghav C. Dwivedi 2015

Authors and Affiliations

  1. 1.Department of SurgerySt. Paul’s Hospital & University of British ColumbiaVancouverCanada

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