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The Care of the HPV-Negative Head and Neck Cancer Patient: Presentation, Prognosis, Treatment

  • Anthony J. Cmelak
  • Eleni Rettig
  • F. Christopher Holsinger
Part of the Head and Neck Cancer Clinics book series (HNCC)

Abstract

Chaturvedi et al. [1] recently described the population-based estimated incidence of HPV-positive and HPV-negative OPC in the USA using the Surveillance, Epidemiology, and End Results (SEER) database [1]. From 1988 to 2004, HPV-positive OPC increased by 225 % (95 % CI 208 − 242 %; from 0.8 per 100,000 to 2.6 per 100,000), whereas the incidence of HPV-negative cancers declined by 50 % (95 % CI 47 − 53 %; from 2.0 per 100,000 to 1.0 per 100,000). The American Cancer Society estimated that 52,140 new cases of laryngeal, oral and pharyngeal cancers would occur in 2011 [2]. A limitation of these estimates is the difficulty in ascertaining the proportion of ‘oral cavity and pharynx cancers’ that are OPCs per se.

Keywords

Overall Survival Induction Chemotherapy Radiation Therapy Oncology Group Normal Tissue Complication Probability Transoral Laser Microsurgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Carole Fakhry, Gypsyamber D’Souza, Rehan Kazi and Raghav C. Dwivedi 2015

Authors and Affiliations

  • Anthony J. Cmelak
    • 1
  • Eleni Rettig
    • 2
  • F. Christopher Holsinger
    • 3
  1. 1.Department of Radiation OncologyVanderbilt-Ingram Cancer CenterNashvilleUSA
  2. 2.Department of Otolaryngology – Head and Neck SurgeryThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of Otolaryngology – Head and Neck SurgeryStandford University Medical CenterStanfordUSA

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