Epidemiology of Oral HPV Infection and HPV-Associated Head and Neck Cancer

Part of the Head and Neck Cancer Clinics book series (HNCC)


Tobacco and alcohol exposure are the traditional risk factors for malignancies of the head and neck, and account for approximately three-quarters of all cases worldwide and half of the cases in the USA [1]. Infection with human papillomavirus (HPV), particularly type 16, has also been established as yet another important risk factor [2–5]. The overwhelming majority of HPV-associated head and neck cancers (HPV-HNSCCs) arise from the oropharynx [2, 6]. HPV-positive oropharyngeal cancer (OPC) represents a growing aetiologically distinct subset of head and neck cancers, with unique epidemiological, clinical and molecular characteristics that differ from those of HPV-negative cancers.


Standardize Incidence Ratio Tongue Cancer Tonsillar Cancer Tonsillar Squamous Cell Carcinoma 


  1. 1.
    Hashibe M, Brennan P, Chuang SC, et al. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev. 2009;18:541–50.PubMedCentralPubMedGoogle Scholar
  2. 2.
    Gillison ML, Koch WM, Capone RB, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92:709–20.PubMedGoogle Scholar
  3. 3.
    D’Souza G, Kreimer AR, Viscidi R, et al. Case–control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007;356:1944–56.PubMedGoogle Scholar
  4. 4.
    Herrero R, Castellsague X, Pawlita M, et al. Human papillomavirus and oral cancer: The International Agency for Research on Cancer multicenter study. J Natl Cancer Inst. 2003;95:1772–83.PubMedGoogle Scholar
  5. 5.
    Schwartz SM, Daling JR, Doody DR, et al. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst. 1998;90:1626–36.PubMedGoogle Scholar
  6. 6.
    Paz IB, Cook N, Odom-Maryon T, et al. Human papillomavirus (HPV) in head and neck cancer. An association of HPV16 with squamous cell carcinoma of Waldeyer’s tonsillar ring. Cancer. 1997;79:595–604.PubMedGoogle Scholar
  7. 7.
    Kreimer AR, Clifford GM, Boyle P, et al. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev. 2005;14:467–75.PubMedGoogle Scholar
  8. 8.
    Syrjanen S, Lodi G, von Bultzingslowen I, et al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 2011;17 Suppl 1:58–72.PubMedGoogle Scholar
  9. 9.
    de Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13:607–15.PubMedGoogle Scholar
  10. 10.
    Carvalho AL, Nishimoto IN, Califano JA, et al. Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer. 2005;114:806–16.PubMedGoogle Scholar
  11. 11.
    Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the US population ages 20–44 years. Cancer. 2005;103:1843–9.PubMedGoogle Scholar
  12. 12.
    Nasman A, Attner P, Hammarstedt L, et al. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer. 2009;125:362–6.PubMedGoogle Scholar
  13. 13.
    Auluck A, Hislop G, Bajdik C, et al. Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. Cancer. 2010;116:2635–44.PubMedGoogle Scholar
  14. 14.
    Johnson-Obaseki S, McDonald JT, Corsten M, et al. Head and neck cancer in Canada: trends 1992 to 2007. Otolaryngol Head Neck Surg. 2012;147:74–8.PubMedGoogle Scholar
  15. 15.
    Blomberg M, Nielsen A, Munk C, et al. Trends in head and neck cancer incidence in Denmark, 1978–2007: focus on human papillomavirus associated sites. Int J Cancer. 2011;129:733–41.PubMedGoogle Scholar
  16. 16.
    Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer. 2007;110:1429–35.PubMedGoogle Scholar
  17. 17.
    Dillner J. Trends over time in the incidence of cervical neoplasia in comparison to trends over time in human papillomavirus infection. J Clin Virol. 2000;19:7–23.PubMedGoogle Scholar
  18. 18.
    af Geijersstam V, Wang Z, Lewensohn-Fuchs I, et al. Trends in seroprevalence of human papillomavirus type 16 among pregnant women in Stockholm, Sweden, during 1969–1989. Int J Cancer. 1998;76:341–4.Google Scholar
  19. 19.
    Ernster JA, Sciotto CG, O’Brien MM, et al. Rising incidence of oropharyngeal cancer and the role of oncogenic human papilloma virus. Laryngoscope. 2007;117:2115–28.PubMedGoogle Scholar
  20. 20.
    Hammarstedt L, Lindquist D, Dahlstrand H, et al. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer. 2006;119:2620–3.PubMedGoogle Scholar
  21. 21.
    Turner CF, Danella RD, Rogers SM. Sexual behavior in the United States 1930–1990: trends and methodological problems. Sex Transm Dis. 1995;22:173–90.PubMedGoogle Scholar
  22. 22.
    de Sanjose S, Diaz M, Castellsague X, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007;7:453–9.PubMedGoogle Scholar
  23. 23.
    Weinstock H, Berman S, Cates Jr W. Sexually transmitted diseases among American youth: incidence and prevalence estimates, 2000. Perspect Sex Reprod Health. 2004;36:6–10.PubMedGoogle Scholar
  24. 24.
    Gillison ML, Broutian T, Pickard RK, et al. Prevalence of oral HPV infection in the United States, 2009–2010. JAMA. 2012;307:693–703.PubMedGoogle Scholar
  25. 25.
    Sanders A, Slade G, Patton L. National prevalence of oral HPV infection and related risk factors in the US adult population. Oral Dis. 2012;18:430–41.PubMedGoogle Scholar
  26. 26.
    D’Souza G, Fakhry C, Sugar EA, et al. Six-month natural history of oral versus cervical human papillomavirus infection. Int J Cancer. 2007;121:143–50.PubMedGoogle Scholar
  27. 27.
    Hariri S, Unger ER, Sternberg M, et al. Prevalence of genital human papillomavirus among females in the United States, the National Health and Nutrition Examination Survey, 2003–2006. J Infect Dis. 2011;204:566–73.PubMedGoogle Scholar
  28. 28.
    Datta SD, Koutsky LA, Ratelle S, et al. Human papillomavirus infection and cervical cytology in women screened for cervical cancer in the United States, 2003–2005. Ann Intern Med. 2008;148:493–500.PubMedGoogle Scholar
  29. 29.
    Kreimer AR, Bhatia RK, Messeguer AL, et al. Oral human papillomavirus in healthy individuals: a systematic review of the literature. Sex Transm Dis. 2010;37:386–91.PubMedGoogle Scholar
  30. 30.
    Fakhry C, D’souza G, Sugar E, et al. Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women. J Clin Microbiol. 2006;44:4479–85.PubMedCentralPubMedGoogle Scholar
  31. 31.
    D’Souza G, Agrawal Y, Halpern J, et al. Oral sexual behaviors associated with prevalent oral human papillomavirus infection. J Infect Dis. 2009;199:1263–9.PubMedGoogle Scholar
  32. 32.
    Smith EM, Swarnavel S, Ritchie JM, et al. Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescents. Pediatr Infect Dis J. 2007;26:836–40.PubMedGoogle Scholar
  33. 33.
    Kreimer AR, Alberg AJ, Daniel R, et al. Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J Infect Dis. 2004;189:686–98.PubMedGoogle Scholar
  34. 34.
    Beachler DC, Weber KM, Margolick JB, et al. Risk factors for oral HPV infection among a high prevalence population of HIV-positive and at-risk HIV-negative adults. Cancer Epidemiol Biomarkers Prev. 2012;21:122–33.PubMedCentralPubMedGoogle Scholar
  35. 35.
    Mork J, Lie AK, Glattre E, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 2001;344:1125–31.PubMedGoogle Scholar
  36. 36.
    Gillison ML, D’Souza G, Westra W, et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008;100:407–20.PubMedGoogle Scholar
  37. 37.
    Smith EM, Ritchie JM, Summersgill KF, et al. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer. 2004;108:766–72.PubMedGoogle Scholar
  38. 38.
    Hobbs CG, Sterne JA, Bailey M, et al. Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol. 2006;31:259–66.PubMedGoogle Scholar
  39. 39.
    Ji X, Neumann AS, Sturgis EM, et al. P53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers. Carcinogenesis. 2008;29:875–9.PubMedGoogle Scholar
  40. 40.
    Attner P, Du J, Nasman A, et al. The role of human papillomavirus in the increased incidence of base of tongue cancer. Int J Cancer. 2010;126:2879–84.PubMedGoogle Scholar
  41. 41.
    Kreimer AR, Villa A, Nyitray AG, et al. The epidemiology of oral HPV infection among a multinational sample of healthy men. Cancer Epidemiol Biomarkers Prev. 2011;20:172–82.PubMedCentralPubMedGoogle Scholar
  42. 42.
    Pickard RK, Xiao W, Broutian TR, et al. The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18–30 years. Sex Transm Dis. 2012;39:559–66.PubMedGoogle Scholar
  43. 43.
    Brown B, Blas MM, Cabral A, et al. Oral sex practices, oral human papillomavirus and correlations between oral and cervical human papillomavirus prevalence among female sex workers in Lima, Peru. Int J STD AIDS. 2011;22:655–8.PubMedGoogle Scholar
  44. 44.
    Castellsague X, Munoz N. Chapter 3: cofactors in human papillomavirus carcinogenesis—role of parity, oral contraceptives, and tobacco smoking. J Natl Cancer Inst Monogr. 2003;31:20–8.PubMedGoogle Scholar
  45. 45.
    Arnson Y, Shoenfeld Y, Amital H. Effects of tobacco smoke on immunity, inflammation and autoimmunity. J Autoimmun. 2010;34:J258–65.PubMedGoogle Scholar
  46. 46.
    Termine N, Giovannelli L, Matranga D, et al. Oral human papillomavirus infection in women with cervical HPV infection: new data from an Italian cohort and a metanalysis of the literature. Oral Oncol. 2011;47:244–50.PubMedGoogle Scholar
  47. 47.
    Eaton DK, Lowry R, Brener ND, et al. Trends in human immunodeficiency virus-and sexually transmitted disease-related risk behaviors among U.S. high school students, 1991–2009. Am J Prev Med. 2011;40:427–33.PubMedGoogle Scholar
  48. 48.
    Santelli JS, Lindberg LD, Abma J, et al. Adolescent sexual behavior: estimates and trends from four nationally representative surveys. Fam Plann Perspect. 2000;32:156–65.PubMedGoogle Scholar
  49. 49.
    Santelli JS, Orr M, Lindberg LD, et al. Changing behavioral risk for pregnancy among high school students in the United States, 1991–2007. J Adolesc Health. 2009;45:25–32.PubMedGoogle Scholar
  50. 50.
    Warren CW, Santelli JS, Everett SA, et al. Sexual behavior among U.S. high school students, 1990–1995. Fam Plann Perspect. 1998;30:170–2.PubMedGoogle Scholar
  51. 51.
    Johnson AM, Mercer CH, Erens B, et al. Sexual behaviour in Britain: partnerships, practices, and HIV risk behaviours. Lancet. 2001;358:1835–42.PubMedGoogle Scholar
  52. 52.
    Agius PA, Pitts MK, Smith AM, et al. Sexual behaviour and related knowledge among a representative sample of secondary school students between 1997 and 2008. Aust N Z J Public Health. 2010;34:476–81.PubMedGoogle Scholar
  53. 53.
    Bajos N, Bozon M, Beltzer N, et al. Changes in sexual behaviours: from secular trends to public health policies. AIDS. 2010;24:1185–91.PubMedGoogle Scholar
  54. 54.
    Herlitz C. Sexual risk-taking in the general population of Sweden (1989–2007). Sex Health. 2009;6:272–80.PubMedGoogle Scholar
  55. 55.
    Eaton DK, Kann L, Kinchen S, et al. Youth risk behavior surveillance – United States, 2011. MMWR Surveill Summ. 2012;61:1–162.PubMedGoogle Scholar
  56. 56.
    Burchell AN, Coutlee F, Tellier PP, et al. Genital transmission of human papillomavirus in recently formed heterosexual couples. J Infect Dis. 2011;204:1723–9.PubMedCentralPubMedGoogle Scholar
  57. 57.
    Hernandez BY, Wilkens LR, Zhu X, et al. Transmission of human papillomavirus in heterosexual couples. Emerg Infect Dis. 2008;14:888–94.PubMedCentralPubMedGoogle Scholar
  58. 58.
    Winer RL, Lee SK, Hughes JP, et al. Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students. Am J Epidemiol. 2003;157:218–26.PubMedGoogle Scholar
  59. 59.
    Widdice LE, Breland DJ, Jonte J, et al. Human papillomavirus concordance in heterosexual couples. J Adolesc Health. 2010;47:151–9.PubMedCentralPubMedGoogle Scholar
  60. 60.
    Kero K, Rautava J, Syrjanen K, et al. Human papillomavirus genotypes in male genitalia and their concordance among pregnant spouses participating in the Finnish family HPV study. J Sex Med. 2011;8:2522–31.PubMedGoogle Scholar
  61. 61.
    Giraldo P, Goncalves AK, Pereira SA, et al. Human papillomavirus in the oral mucosa of women with genital human papillomavirus lesions. Eur J Obstet Gynecol Reprod Biol. 2006;126:104–6.PubMedGoogle Scholar
  62. 62.
    Smith E, Parker M, Rubenstein L, et al. Evidence for vertical transmission of HPV from mothers to infants. Infect Dis Obstet Gynecol. 2010;2010:326–9.Google Scholar
  63. 63.
    Watts DH, Koutsky LA, Holmes KK, et al. Low risk of perinatal transmission of human papillomavirus: results from a prospective cohort study. Am J Obstet Gynecol. 1998;178:365–73.PubMedGoogle Scholar
  64. 64.
    Smith EM, Ritchie JM, Yankowitz J, et al. Human papillomavirus prevalence and types in newborns and parents: concordance and modes of transmission. Sex Transm Dis. 2004;31:57–62.PubMedGoogle Scholar
  65. 65.
    Tenti P, Zappatore R, Migliora P, et al. Perinatal transmission of human papillomavirus from gravidas with latent infections. Obstet Gynecol. 1999;93:475–9.PubMedGoogle Scholar
  66. 66.
    Rombaldi RL, Serafini EP, Mandelli J, et al. Perinatal transmission of human papilomavirus DNA. Virol J. 2009;6:83.PubMedCentralPubMedGoogle Scholar
  67. 67.
    Sarkola ME, Grenman SE, Rintala MA, et al. Human papillomavirus in the placenta and umbilical cord blood. Acta Obstet Gynecol Scand. 2008;87:1181–8.PubMedGoogle Scholar
  68. 68.
    Puranen M, Yliskoski M, Saarikoski S, et al. Vertical transmission of human papillomavirus from infected mothers to their newborn babies and persistence of the virus in childhood. Am J Obstet Gynecol. 1996;174:694–9.PubMedGoogle Scholar
  69. 69.
    Rombaldi RL, Serafini EP, Mandelli J, et al. Transplacental transmission of human papillomavirus. Virol J. 2008;5:106.PubMedCentralPubMedGoogle Scholar
  70. 70.
    Koskimaa HM, Waterboer T, Pawlita M, et al. Human papillomavirus genotypes present in the oral mucosa of newborns and their concordance with maternal cervical human papillomavirus genotypes. J Pediatr. 2012;160:837–43.PubMedGoogle Scholar
  71. 71.
    Armbruster-Moraes E, Ioshimoto LM, Leao E, et al. Presence of human papillomavirus DNA in amniotic fluids of pregnant women with cervical lesions. Gynecol Oncol. 1994;54:152–8.PubMedGoogle Scholar
  72. 72.
    Quick CA, Watts SL, Krzyzek RA, et al. Relationship between condylomata and laryngeal papillomata. Clinical and molecular virological evidence. Ann Otol Rhinol Laryngol. 1980;89:467–71.PubMedGoogle Scholar
  73. 73.
    Silverberg MJ, Thorsen P, Lindeberg H, et al. Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol. 2003;101:645–52.PubMedGoogle Scholar
  74. 74.
    Venkatesan NN, Pine HS, Underbrink MP. Recurrent respiratory papillomatosis. Otolaryngol Clin North Am. 2012;45:671–94.PubMedCentralPubMedGoogle Scholar
  75. 75.
    Tseng CJ, Liang CC, Soong YK, et al. Perinatal transmission of human papillomavirus in infants: relationship between infection rate and mode of delivery. Obstet Gynecol. 1998;91:92–6.PubMedGoogle Scholar
  76. 76.
    Rautava J, Willberg J, Louvanto K, et al. Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study. PLoS One. 2012;7, e42171.PubMedCentralPubMedGoogle Scholar
  77. 77.
    Smith EM, Ritchie JM, Pawlita M, et al. Human papillomavirus seropositivity and risks of head and neck cancer. Int J Cancer. 2007;120:825–32.PubMedGoogle Scholar
  78. 78.
    Dahlstrom KR, Adler-Storthz K, Etzel CJ, et al. Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis. Clin Cancer Res. 2003;9:2620–6.PubMedGoogle Scholar
  79. 79.
    Strome SE, Savva A, Brissett AE, et al. Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations. Clin Cancer Res. 2002;8:1093–100.PubMedGoogle Scholar
  80. 80.
    Gillison ML. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Semin Oncol. 2004;31:744–54.PubMedGoogle Scholar
  81. 81.
    El-Mofty SK, Patil S. Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:339–45.PubMedGoogle Scholar
  82. 82.
    Ritchie JM, Smith EM, Summersgill KF, et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer. 2003;104:336–44.PubMedGoogle Scholar
  83. 83.
    Capone RB, Pai SI, Koch WM, et al. Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma. Clin Cancer Res. 2000;6:4171–5.PubMedGoogle Scholar
  84. 84.
    Gillison ML, Koch WM, Shah KV. Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease? Curr Opin Oncol. 1999;11:191–9.PubMedGoogle Scholar
  85. 85.
    Chaturvedi AK. Epidemiology and clinical aspects of HPV in head and neck cancers. Head Neck Pathol. 2012;6 Suppl 1:S16–24.PubMedGoogle Scholar
  86. 86.
    Hong AM, Dobbins TA, Lee CS, et al. Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy. Br J Cancer. 2010;103:1510–7.PubMedCentralPubMedGoogle Scholar
  87. 87.
    D’Souza G, Zhang HH, D’Souza WD, et al. Moderate predictive value of demographic and behavioral characteristics for a diagnosis of HPV16-positive and HPV16-negative head and neck cancer. Oral Oncol. 2010;46:100–4.PubMedCentralPubMedGoogle Scholar
  88. 88.
    Guan X, Sturgis EM, Lei D, et al. Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer. Clin Cancer Res. 2010;16:1416–22.PubMedCentralPubMedGoogle Scholar
  89. 89.
    Settle K, Posner MR, Schumaker LM, et al. Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients. Cancer Prev Res (Phila). 2009;2:776–81.Google Scholar
  90. 90.
    Dahlstrom KR, Li G, Tortolero-Luna G, et al. Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites. Head Neck. 2011;33:847–55.PubMedCentralPubMedGoogle Scholar
  91. 91.
    Heck JE, Berthiller J, Vaccarella S, et al. Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head And Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol. 2010;39:166–81.PubMedCentralPubMedGoogle Scholar
  92. 92.
    Marur S, Forastiere AA. Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clin Proc. 2008;83:489–501.PubMedGoogle Scholar
  93. 93.
    Applebaum KM, Furniss CS, Zeka A, et al. Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Natl Cancer Inst. 2007;99:1801–10.PubMedGoogle Scholar
  94. 94.
    Smith EM, Rubenstein LM, Haugen TH, et al. Tobacco and alcohol use increases the risk of both HPV-associated and HPV-independent head and neck cancers. Cancer Causes Control. 2010;21:1369–78.PubMedGoogle Scholar
  95. 95.
    Hemminki K, Dong C, Vaittinen P. Second primary cancer after in situ and invasive cervical cancer. Epidemiology. 2000;11:457–61.PubMedGoogle Scholar
  96. 96.
    Hemminki K, Dong C. Cancer in husbands of cervical cancer patients. Epidemiology. 2000;11:347–9.PubMedGoogle Scholar
  97. 97.
    Chaturvedi AK, Engels EA, Gilbert ES, et al. Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk. J Natl Cancer Inst. 2007;99:1634–43.PubMedGoogle Scholar
  98. 98.
    Chaturvedi AK, Kleinerman RA, Hildesheim A, et al. Second cancers after squamous cell carcinoma and adenocarcinoma of the cervix. J Clin Oncol. 2009;27:967–73.PubMedCentralPubMedGoogle Scholar
  99. 99.
    Hemminki K, Dong C, Frisch M. Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands. Eur J Cancer Prev. 2000;9:433–7.PubMedGoogle Scholar
  100. 100.
    Sikora AG, Morris LG, Sturgis EM. Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in men. Arch Otolaryngol Head Neck Surg. 2009;135:402–5.PubMedGoogle Scholar
  101. 101.
    Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst. 2000;92:1500–10.PubMedGoogle Scholar
  102. 102.
    Chaturvedi AK, Madeleine MM, Biggar RJ, et al. Risk of human papillomavirus-associated cancers among persons with AIDS. J Natl Cancer Inst. 2009;101:1120–30.PubMedCentralPubMedGoogle Scholar
  103. 103.
    Clifford GM, Polesel J, Rickenbach M, et al. Cancer risk in the swiss HIV cohort study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst. 2005;97:425–32.PubMedGoogle Scholar
  104. 104.
    Engels EA, Biggar RJ, Hall HI, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer. 2008;123:187–94.PubMedGoogle Scholar
  105. 105.
    Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29.PubMedGoogle Scholar
  106. 106.
    Giovino GA. The tobacco epidemic in the United States. Am J Prev Med. 2007;33(6 Suppl):S318–26.PubMedGoogle Scholar
  107. 107.
    Surveillance, epidemiology and end results. Fast stats: an interactive tool for access to SEER cancer statistics. Surveillance Research Program, National Cancer Institute. http://seer.cancer.gov/faststats. Accessed on 25 June 2012.
  108. 108.
    Chaturvedi AK, Engels EA, Anderson WF, et al. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008;26:612–9.PubMedGoogle Scholar
  109. 109.
    Mork J, Moller B, Dahl T, et al. Time trends in pharyngeal cancer incidence in Norway 1981–2005: a subsite analysis based on a reabstraction and recoding of registered cases. Cancer Causes Control. 2010;21:1397–405.PubMedGoogle Scholar
  110. 110.
    Licitra L, Zigon G, Gatta G, et al. Human papillomavirus in HNSCC: a European epidemiologic perspective. Hematol Oncol Clin North Am. 2008;22:1143–53.PubMedGoogle Scholar
  111. 111.
    Brown LM, Check DP, Devesa SS. Oral cavity and pharynx cancer incidence trends by subsite in the United States: changing gender patterns. J Oncol. 2012;2012:649498.PubMedCentralPubMedGoogle Scholar
  112. 112.
    Mehta V, Yu GP, Schantz SP. Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics. Laryngoscope. 2010;120:2203–12.PubMedGoogle Scholar
  113. 113.
    Ryerson AB, Peters ES, Coughlin SS, et al. Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998–2003. Cancer. 2008;113(10 Suppl):2901–9.PubMedGoogle Scholar
  114. 114.
    Chaturvedi AK, Engels EA, Pfeiffer RM, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29:4294–301.PubMedCentralPubMedGoogle Scholar
  115. 115.
    Frisch M, Hjalgrim H, Jaeger AB, et al. Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Control. 2000;11:489–95.PubMedGoogle Scholar
  116. 116.
    Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 2009;21:194–200.PubMedGoogle Scholar
  117. 117.
    Ragin CC, Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer. 2007;121:1813–20.PubMedGoogle Scholar
  118. 118.
    Fakhry C, Westra WH, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008;100:261–9.PubMedGoogle Scholar
  119. 119.
    Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363:24–35.PubMedCentralPubMedGoogle Scholar
  120. 120.
    Rischin D, Young RJ, Fisher R, et al. Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. J Clin Oncol. 2010;28:4142–8.PubMedCentralPubMedGoogle Scholar
  121. 121.
    Lassen P, Eriksen JG, Hamilton-Dutoit S, et al. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol. 2009;27:1992–8.PubMedGoogle Scholar
  122. 122.
    Sturgis EM, Ang KK. The epidemic of HPV-associated oropharyngeal cancer is here: is it time to change our treatment paradigms? J Natl Compr Canc Netw. 2011;9:665–73.PubMedGoogle Scholar
  123. 123.
    Ang KK, Sturgis EM. Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma. Semin Radiat Oncol. 2012;22:128–42.PubMedGoogle Scholar
  124. 124.
    Kumar B, Cordell KG, Lee JS, et al. Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking. Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S109–11.PubMedCentralPubMedGoogle Scholar
  125. 125.
    Hafkamp HC, Manni JJ, Haesevoets A, et al. Marked differences in survival rate between smokers and nonsmokers with HPV16-associated tonsillar carcinomas. Int J Cancer. 2008;122:2656–64.PubMedGoogle Scholar
  126. 126.
    Hong AM, Martin A, Chatfield M, et al. Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma. Int J Cancer. 2013;132:2748–54.PubMedGoogle Scholar
  127. 127.
    Gillison ML, Zhang Q, Jordan R, et al. Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. J Clin Oncol. 2012;30:2102–11.PubMedCentralPubMedGoogle Scholar
  128. 128.
    Hammarstedt L, Lu Y, Marklund L, et al. Differential survival trends for patients with tonsillar, base of tongue and tongue cancer in Sweden. Oral Oncol. 2011;47:636–41.PubMedGoogle Scholar
  129. 129.
    Donovan B, Franklin N, Guy R, et al. Quadrivalent human papillomavirus vaccination and trends in genital warts in Australia: analysis of national sentinel surveillance data. Lancet Infect Dis. 2011;11:39–44.PubMedGoogle Scholar
  130. 130.
    Brisson M, van de Velde N, Franco EL, et al. Incremental impact of adding boys to current human papillomavirus vaccination programs: role of herd immunity. J Infect Dis. 2011;204:372–6.PubMedGoogle Scholar
  131. 131.
    Centers for Disease Control and Prevention (CDC). FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 2010;59:626–9.Google Scholar
  132. 132.
    Centers for Disease Control and Prevention (CDC). National and state vaccination coverage among adolescents aged 13 through 17 years—United States, 2010. MMWR Morb Mortal Wkly Rep. 2011;60:1117–23.Google Scholar
  133. 133.
    Centers for Disease Control and Prevention (CDC). Recommendations on the use of quadrivalent human papillomavirus vaccine in males—Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 2011;60:1705–8.Google Scholar
  134. 134.
    Fakhry C, Rosenthal BT, Clark DP, et al. Associations between oral HPV16 infection and cytopathology: evaluation of an oropharyngeal ‘pap-test equivalent’ in high-risk populations. Cancer Prev Res (Phila). 2011;4:1378–84.Google Scholar
  135. 135.
    Brandsma JL, Abramson AL. Association of papillomavirus with cancers of the head and neck. Arch Otolaryngol Head Neck Surg. 1989;115:621–5.PubMedGoogle Scholar
  136. 136.
    Niedobitek G, Pitteroff S, Herbst H, et al. Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil. J Clin Pathol. 1990;43:918–21.PubMedCentralPubMedGoogle Scholar
  137. 137.
    Ogura H, Watanabe S, Fukushima K, et al. Presence of human papillomavirus type 18 DNA in a pharyngeal and a laryngeal carcinoma. Jpn J Cancer Res. 1991;82:1184–6.PubMedGoogle Scholar
  138. 138.
    Brachman DG, Graves D, Vokes E, et al. Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer. Cancer Res. 1992;52:4832–6.PubMedGoogle Scholar
  139. 139.
    Cruz IB, Snijders PJ, Steenbergen RD, et al. Age-dependence of human papillomavirus DNA presence in oral squamous cell carcinomas. Eur J Cancer B Oral Oncol. 1996;32B:55–62.PubMedGoogle Scholar
  140. 140.
    Fouret P, Monceaux G, Temam S, et al. Human papillomavirus in head and neck squamous cell carcinomas in nonsmokers. Arch Otolaryngol Head Neck Surg. 1997;123:513–6.PubMedGoogle Scholar
  141. 141.
    Fukushima K, Ogura H, Watanabe S, et al. Human papillomavirus type 16 DNA detected by the polymerase chain reaction in non-cancer tissues of the head and neck. Eur Arch Otorhinolaryngol. 1994;251:109–12.PubMedGoogle Scholar
  142. 142.
    Koch WM, Lango M, Sewell D, et al. Head and neck cancer in nonsmokers: a distinct clinical and molecular entity. Laryngoscope. 1999;109:1544–51.PubMedGoogle Scholar
  143. 143.
    Mineta H, Ogino T, Amano HM, et al. Human papilloma virus (HPV) type 16 and 18 detected in head and neck squamous cell carcinoma. Anticancer Res. 1998;18:4765–8.PubMedGoogle Scholar
  144. 144.
    Nishioka S, Fukushima K, Nishizaki K, et al. Human papillomavirus as a risk factor for head and neck cancers—a case–control study. Acta Otolaryngol Suppl. 1999;540:77–80.PubMedGoogle Scholar
  145. 145.
    Reimers N, Kasper HU, Weissenborn SJ, et al. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer. 2007;120:1731–8.PubMedGoogle Scholar
  146. 146.
    Ringstrom E, Peters E, Hasegawa M, et al. Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res. 2002;8:3187–92.PubMedGoogle Scholar
  147. 147.
    Romanitan M, Nasman A, Ramqvist T, et al. Human papillomavirus frequency in oral and oropharyngeal cancer in Greece. Anticancer Res. 2008;28:2077–80.PubMedGoogle Scholar
  148. 148.
    Snijders PJ, Scholes AG, Hart CA, et al. Prevalence of mucosotropic human papillomaviruses in squamous-cell carcinoma of the head and neck. Int J Cancer. 1996;66:464–9.PubMedGoogle Scholar
  149. 149.
    Hansson BG, Rosenquist K, Antonsson A, et al. Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case–control study in southern Sweden. Acta Otolaryngol. 2005;125:1337–44.PubMedGoogle Scholar
  150. 150.
    Klozar J, Kratochvil V, Salakova M, et al. HPV status and regional metastasis in the prognosis of oral and oropharyngeal cancer. Eur Arch Otorhinolaryngol. 2008;265 Suppl 1:S75–82.PubMedGoogle Scholar
  151. 151.
    Klussmann JP, Weissenborn SJ, Wieland U, et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer. 2001;92:2875–84.PubMedGoogle Scholar
  152. 152.
    Lindel K, Beer KT, Laissue J, et al. Human papillomavirus positive squamous cell carcinoma of the oropharynx: a radiosensitive subgroup of head and neck carcinoma. Cancer. 2001;92:805–13.PubMedGoogle Scholar
  153. 153.
    Pintos J, Black MJ, Sadeghi N, et al. Human papillomavirus infection and oral cancer: a case–control study in Montreal, Canada. Oral Oncol. 2008;44:242–50.PubMedGoogle Scholar
  154. 154.
    Tachezy R, Klozar J, Salakova M, et al. HPV and other risk factors of oral cavity/oropharyngeal cancer in the Czech Republic. Oral Dis. 2005;11:181–5.PubMedGoogle Scholar
  155. 155.
    van Houten VM, Snijders PJ, van den Brekel MW, et al. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int J Cancer. 2001;93:232–5.PubMedGoogle Scholar
  156. 156.
    Tachezy R, Klozar J, Rubenstein L, et al. Demographic and risk factors in patients with head and neck tumors. J Med Virol. 2009;81:878–87.PubMedGoogle Scholar
  157. 157.
    D’Souza G, Dempsey A. The role of HPV in head and neck cancer and review of the HPV vaccine. Prev Med. 2011;53 Suppl 1:S5–11.PubMedCentralPubMedGoogle Scholar

Copyright information

© Carole Fakhry, Gypsyamber D’Souza, Rehan Kazi and Raghav C. Dwivedi 2015

Authors and Affiliations

  1. 1.Department of Head and Neck Surgery, MD Anderson Cancer CenterThe University of TexasHoustonUSA

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