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Immunosuppressives in Uveitis and Ocular Inflammation

  • Pichaporn Artornsombudh
  • John H. Kempen

Abstract

Inadequately controlled uveitis is a leading cause of permanent visual loss, accounting for 5–20 % of cases of legal blindness [1–4]. Ocular inflammation is the principal cause of complications and morbidities. Delayed or inadequate control of inflammation can lead to serious sequelae resulting in visual impairment [5–8]. Therefore, the primary goal of management is to control the inflammation. There are two phases of treatment of ocular inflammation. First is induction of control of inflammation, the goal of which is to suppress the sight-threatening ocular inflammation as soon as possible with a rapidly effective medication, usually using topical, systemic, and/or injected corticosteroids. For remitting forms of uveitis, this may be the only treatment necessary. For chronic disease requiring suppressive therapy, the second aim is maintenance of control of inflammation after successful treatment in order to prevent recurrence or relapse of the ocular inflammation. Immunosuppressives have their primary role in maintenance of control of inflammation.

Keywords

Juvenile Idiopathic Arthritis Mycophenolate Mofetil Ocular Inflammation Relapse Polychondritis Intravenous Cyclophosphamide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of Interest

None

Financial Disclosures

The author(s) have made the following disclosure(s): John H. Kempen: (consultant) Abbvie; (consultant) Lux Biosciences; (consultant) Allergan; (consultant) Alcon; (consultant) Can-Fite; (consultant) Clearside; (consultant) Xoma.

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Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Department of OphthalmologySomdech Phra Pinkloa HospitalBangkokThailand
  2. 2.Department of OphthalmologyChulalongkorn UniversityBangkokThailand
  3. 3.Ophthalmic EpidemiologyProfessor of Ophthalmology, Professor of Epidemiology in Biostatistics and Epidemiology, The Scheie Eye InstitutePhiladelphiaUSA
  4. 4.Department of OphthalmologyCenter for Preventive Ophthalmology and BiostatisticsPhiladelphiaUSA
  5. 5.Department of Biostatistics and EpidemiologyThe Center for Clinical Epidemiology and Biostatistics, The Perelman School of Medicine, University of PennsylvaniaPhiladelphiaUSA

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