Skip to main content

White Dot Syndromes

  • Chapter
Uveitis: An Update
  • 1181 Accesses

Abstract

Visual loss with an etiology that is localized to the posterior segment of the eye and more precisely the choroid needs to be further analyzed to discern whether the disease is caused by an autoimmune process or infection. White dot syndromes (WDS) or inflammatory chorioretinopathies are an overlapping group of inflammatory disorders with clinical features that share the common presence of discrete, multiple, well-circumscribed, yellow-white lesions at the level of the retina, retinal pigment epithelium (RPE), choriocapillaries, and choroid. The various diagnoses are differentiated by history, clinical appearance, laterality, and imaging. Laboratory investigations are not routinely necessary for their diagnosis but are essential for monitoring therapy-related side effects. A significant percentage of patients with WDS have a prodromal viral-like illness that triggers the onset of the ocular condition. Although self-limiting, they need to be followed up closely for complications such as scarring and choroidal neovascular membranes (CNVM). Patients with WDS present with sudden blurring of vision often associated with photopsia, floaters, scotomata, and metamorphopsia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Jyotirmay B, Jafferji SS, Sudharshan S, Kalpana B. Clinical profile, treatment, and visual outcome of ampiginous choroiditis. Ocul Immunol Inflamm. 2010;18(1):46–51.

    PubMed  Google Scholar 

  2. Biswas J, Narain S, Das D, Ganesh SK. Pattern of uveitis in a referral uveitis clinic in India. Int Ophthalmol. 1996–1997;20(4):223–8.

    Google Scholar 

  3. Laatikainen L, Jokinen E. Immunological studies on serpiginous choroiditis. Graefes Arch Clin Exp Ophthalmol. 1982;219:131–4.

    PubMed  Google Scholar 

  4. Das D, Bhattacharjee H, Bhattacharyya PK, Jain L, Panicker MJ, Das K, Deka AC. Pattern of uveitis in North East India: a tertiary eye care center study. Indian J Ophthalmol. 2009;57:144–6.

    PubMed Central  PubMed  Google Scholar 

  5. Gupta V, Gupta A, Rao NA. Intraocular tuberculosis-an update. Surv Ophthalmol. 2007;52:561–87.

    PubMed  Google Scholar 

  6. Nazari Khanamiri H, Rao NA. Serpiginous choroiditis and infectious multifocal serpiginoid choroiditis. Surv Ophthalmol. 2013;58(3):203–32.

    PubMed  Google Scholar 

  7. Priya K, Madhavan HN, Reiser BJ, et al. Association of herpesviruses in the aqueous humor of patients with serpiginous choroiditis: a polymerase chain reaction-based study. Ocul Immunol Inflamm. 2002;10:253–61.

    PubMed  Google Scholar 

  8. Abrez H, Biswas J, Sudharshan S. Clinical profile, treatment, and visual outcome of serpiginous choroiditis. Ocul Immunol Inflamm. 2007;15(4):325–35.

    CAS  PubMed  Google Scholar 

  9. Sahu DK, Rawoof A, Sujatha B. Macular serpiginous choroiditis. Indian J Ophthalmol. 2002;50(3):189–96.

    PubMed  Google Scholar 

  10. Shi Ji-chuan, Zheng Yue-zhong, Liu Bei. Clinical features and treatment of serpiginous choroiditis. Chin J Pract Ophthalmol. 2008;26:3.

    Google Scholar 

  11. Bansal R, Gupta A, Gupta V. Imaging in the diagnosis and management of serpiginous choroiditis. Int Ophthalmol Clin. 2012;52(4):229–36.

    PubMed  Google Scholar 

  12. Agrawal RV, Biswas J, Gunasekaran D. Indocyanine green angiography in posterior uveitis. Indian J Ophthalmol. 2013;61(4):148–59.

    PubMed Central  PubMed  Google Scholar 

  13. Cardillo Piccolino F, Grosso A, Savini E. Fundus autofluorescence in serpiginous choroiditis. Arch Clin Exp Ophthalmol. 2009;2:179–85.

    Google Scholar 

  14. Gallaghe MJ, Yilmaz T, Cervantes-Castañeda RA, Foster CS. The characteristic features of optical coherence tomography in posterior uveitis. Br J Ophthalmol. 2007;91:1680–5.

    Google Scholar 

  15. Vasconcelos-Santos DV, Rao K, Davies JB, Sohn EH, Rao NA. Clinical features of tuberculous serpiginouslike choroiditis in contrast to classic serpiginous choroiditis. Arch Ophthalmol. 2010;128:853–8.

    PubMed  Google Scholar 

  16. Bansal R, Gupta A, Gupta V, Dogra MR, Sharma A, Bambery P. Tubercular serpiginous-like choroiditis presenting as multifocal serpiginoid choroiditis. Ophthalmology. 2012;119(11):2334–42.

    PubMed  Google Scholar 

  17. Sudharshan S, Ganesh SK, Balu G, Mahalakshmi B, Therese LK, Madhavan HN, Biswas J. Utility of QuantiFERON-TB Gold test in diagnosis and management of suspected tubercular uveitis in India. Int Ophthalmol. 2012;32(3):217–23.

    CAS  PubMed  Google Scholar 

  18. Bhuibhar SS, Biswas J. Nested PCR-positive tubercular ampiginous choroiditis: a case report. Ocul Immunol Inflamm. 2012;20(4):303–5.

    CAS  PubMed  Google Scholar 

  19. Dworkin LL, Gibler TM, Van Gelder RN. Real-time quantitative polymerase chain reaction diagnosis of infectious posterior uveitis. Arch Ophthalmol. 2002;120(11):1534–9.

    CAS  PubMed  Google Scholar 

  20. Rothova A, de Boer JH, Ten Dam-van Loon NH, Postma G, de Visser L, Zuurveen SJ, Schuller M, Weersink AJ, van Loon AM, de Groot-Mijnes JD. Usefulness of aqueous humor analysis for the diagnosis of posterior uveitis. Ophthalmology. 2008;115:306–11.

    PubMed  Google Scholar 

  21. Nikos N, Ioannis H, Simina P, Nikos G, Nikos E, Tasos K. Intravenous pulse methylprednisolone therapy for acute treatment of serpiginous choroiditis. Ocul Immunol Inflamm. 2005;14:29–33.

    Google Scholar 

  22. Seth RK, Gaudio PA. Treatment of serpiginous choroiditis with intravitreous fluocinolone acetonide implant. Ocul Immunol Inflamm. 2008;16(3):103–5.

    PubMed  Google Scholar 

  23. Vianna RNG, Özdal PC, Deschênes J, Burnier MN. Combination of azathioprine and corticosteroids in the treatment of serpiginous choroiditis. Can J Ophthalmol. 2006;41:183–9.

    PubMed  Google Scholar 

  24. Araujo AAQ, Wells AP, Dick AD, Forrester JV. Early treatment with cyclosporin in serpiginous choroidopathy maintains remission and good visual outcome. Br J Ophthalmol. 2000;84:979–82.

    PubMed Central  CAS  PubMed  Google Scholar 

  25. Hooper PL, Kaplan HJ. Triple agent immunosuppression in serpiginous choroiditis. Ophthalmology. 1991;98:944–51.

    CAS  PubMed  Google Scholar 

  26. Sobaci G, Bayraktar Z, Bayer A. Interferon alpha-2a treatment for serpiginous choroiditis. Ocul Immunol Inflamm. 2005;13:59–66.

    CAS  PubMed  Google Scholar 

  27. Akpek KE, Ilhan-Sarac O. New treatments for serpiginous choroiditis. Retina and vitreous disorders. Curr Opin Ophthalmol. 2003;14(3):128–31.

    PubMed  Google Scholar 

  28. Gass JDM. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968;80:177–85.

    CAS  PubMed  Google Scholar 

  29. Savino PJ, Weinberg RJ, Yassin JC, Pilkerton AR. Diverse manifestations of acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol. 1974;77:659–62.

    CAS  PubMed  Google Scholar 

  30. Oleszczuk JD, Saeed MU. Neurological symptoms associated with acute multifocal placoid pigment epitheliopathy: treatment dilemma and diagnostic issues. Semin Ophthalmol. 2015;30:238–40. Posted online on 31 Oct 2013.

    PubMed  Google Scholar 

  31. Montero JA, Ruiz-Moreno JM, Fernandez-Munoz M. Spectral domain optical coherence tomography findings in acute posterior multifocal placoid pigment epitheliopathy. Ocul Immunol Inflamm. 2011;19(1):48–50.

    PubMed  Google Scholar 

  32. Abu-Yaghi NE, Hartono SP, Hodge DO, Pulido JS, Bakri SJ. White dot syndromes: a 20-year study of incidence, clinical features, and outcomes. Ocul Immunol Inflamm. 2011;19:426–30.

    PubMed Central  PubMed  Google Scholar 

  33. Lee GE, Lee BW, Rao NA, Fawzi AA. Spectral domain optical coherence tomography and autofluorescence in a case of acute posterior multifocal placoid pigment epitheliopathy mimicking Vogt-Koyanagi-Harada disease: case report and review of literature. Ocul Immunol Inflamm. 2011;19(1):42–7.

    PubMed  Google Scholar 

  34. Servat JJ, Mears KA, Black EH, Huang JJ. Biological agents for the treatment of uveitis. Expert Opin Biol Ther. 2012;12(3):311–28.

    CAS  PubMed  Google Scholar 

  35. Yenerel NM, Gorgun E, Dinc UA, Oncel M. Treatment of cystoid macular edema due to acute posterior multifocal placoid pigment epitheliopathy. Ocul Immunol Inflamm. 2008;16(1–2):67–71.

    PubMed  Google Scholar 

  36. Baarsma GS, Priem HA, Kijlstra A. Association of birdshot retinochoroidopathy and HLA-A29 antigen. Curr Eye Res. 1990;9(Suppl):63–8.

    PubMed  Google Scholar 

  37. Shah KH, Levinson RD, Yu F, Goldhardt R, Gordon LK, Gonzales CR, Heckenlively JR, Kappel PJ, Holland GN. Birdshot chorioretinopathy. Surv Ophthalmol. 2005;50(6):519–41.

    PubMed  Google Scholar 

  38. Keane PA, Allie M, Turner SJ, Southworth HS, Sadda SR, Murray PI, et al. Characterization of birdshot chorioretinopathy using extramacular enhanced depth optical coherence tomography. JAMA Ophthalmol. 2013;131(3):341–50.

    PubMed  Google Scholar 

  39. Durrani K, Foster CS. Fundus Autofluorescence Imaging in Posterior Uveitis. Semin Ophthalmol. 2012;27(5–6):228–35.

    PubMed  Google Scholar 

  40. Cimino L, Tran VT, Herbort CP. Importance of visual field testing in the functional evaluation and follow-up of birdshot chorioretinopathy. Ophthalmic Res. 2002;34(S1):141.

    Google Scholar 

  41. Comander J, Loewenstein J, Sobrin L. Diagnostic testing and disease monitoring in birdshot chorioretinopathy. Semin Ophthalmol. 2011;26(4–5):329–36.

    PubMed  Google Scholar 

  42. Vitale AT, Rodriguez A, Foster CS. Low-dose cyclosporine therapy in the treatment of birdshot retinochoroidopathy. Ophthalmology. 1994;101(5):822–31.

    CAS  PubMed  Google Scholar 

  43. Cervantes-Castañeda RA, Gonzalez-Gonzalez LA, Cordero-Coma M, Yilmaz T, Foster CS. Combined therapy of cyclosporine A and mycophenolate mofetil for the treatment of birdshot retinochoroidopathy: a 12-month follow-up. Br J Ophthalmol. 2013;97(5):637–43.

    PubMed  Google Scholar 

  44. Rothova A, Ossewaarde-van Norel A, Los LI, Berendschot TT. Efficacy of low-dose methotrexate treatment in birdshot chorioretinopathy. Retina. 2011;31(6):1150–5. [Medline].

    CAS  PubMed  Google Scholar 

  45. Kiss S, Ahmed M, Letko E, Foster CS. Long-term follow-up of patients with birdshot retinochoroidopathy treated with corticosteroid-sparing systemic immunomodulatory therapy. Ophthalmology. 2005 Jun;112(6):1066–71.

    Google Scholar 

  46. Menezo V, Taylor SR. Birdshot uveitis: current and emerging treatment options. Clin Ophthalmol. 2014;8:73–81.

    PubMed Central  PubMed  Google Scholar 

  47. Oh KT, Christmas NJ, Folk JC. Birdshot retinochoroiditis: long term follow-up of a chronically progressive disease. Am J Ophthalmol. 2002;133(5):622–9.

    PubMed  Google Scholar 

  48. Morgan CM, Schatz H. Recurrent multifocal choroiditis. Ophthalmology. 1986;93:1138–47.

    CAS  PubMed  Google Scholar 

  49. Spaide RF, Sugin S, Yannuzzi LA, De Rosa JT. Epstein-Barr virus antibodies in multifocal choroiditis and panuveitis. Am J Ophthalmol. 1991;112:410–3.

    CAS  PubMed  Google Scholar 

  50. Quillen DA, Davis JB, Gottlieb JL, et al. The white dot syndromes. Am J Ophthalmol. 2004;137(3):538–50.

    PubMed  Google Scholar 

  51. Bryan RG, Freund KB, Yannuzzi LA, Spaide RF, Huang SJ, Costa DL. Multiple evanescent white dot syndrome in patients with multifocal choroiditis. Retina. 2002;22(3):317–22. [PubMed].

    PubMed  Google Scholar 

  52. Spaide RF, Yannuzzi LA, Freund KB. Linear streaks in multifocal choroiditis and panuveitis. Retina. 1991;11:229–31.

    CAS  PubMed  Google Scholar 

  53. Kotsolis AI, Killian FA, Ladad ID, Yannuzzi LA. Fluorescein angiography and optical coherence tomography concordance for choroidal neovascularisation in multifocal choroiditis. Br J Ophthalmol. 2010;94:11.

    Google Scholar 

  54. Vance SK, Khan S, Klancnik JM, Freund KB. Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. Retina. 2011;31(4):717–23.

    PubMed  Google Scholar 

  55. Khorram KD, Jampol LM, Rosenberg MA. Blind spot enlargement as a manifestation of multifocal choroiditis. Arch Ophthalmol. 1991;109:1403–7.

    CAS  PubMed  Google Scholar 

  56. Dreyer RF, Gass JDM. Multifocal choroiditis and panuveitis. A syndrome that mimics ocular histoplasmosis. Arch Ophthalmol. 1984;102(12):1776–84.

    CAS  PubMed  Google Scholar 

  57. Ongchin S, Keene CD, Van Gelder R, Vemulakonda GA. A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. J Ophthalmic Inflamm Infect. 2013;3(1):26.

    PubMed Central  PubMed  Google Scholar 

  58. Shakoor A, Vitale AT. Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. Int Ophthalmol Clin. 2012;52(4):243–56.

    PubMed  Google Scholar 

  59. Parodi MB, Iacono P, Kontadakis DS, Zucchiatti I, Cascavilla ML, Bandello F. Bevacizumab vs photodynamic therapy for choroidal neovascularization in multifocal choroiditis. Arch Ophthalmol. 2010;128(9):1100–3.

    PubMed  Google Scholar 

  60. Parnell JR, Jampol LM, Yannuzzi LA, et al. Differentiation between presumed ocular histoplasmosis syndrome and multifocal choroiditis with panuveitis based on morphology of photographed fundus lesions and fluorescein angiography. Arch Ophthalmol. 2001;119:208–12.

    CAS  PubMed  Google Scholar 

  61. Fung AT, Pal S, Yannuzzi NA, Christos P, Cooney M, Slakter JS, Klancnik Jr JM, Freund KB, Cunningham Jr ET, Yannuzzi LA. Multifocal choroiditis without panuveitis: clinical characteristics and progression. Retina. 2014;34(1):98–107.

    PubMed  Google Scholar 

  62. Watzke RC, Packer AJ, Folk JC, Benson WE, Burgess D, Ober RR. Punctate inner choroidopathy. Am J Ophthalmol. 1984;98(5):572–84.

    CAS  PubMed  Google Scholar 

  63. Tiedman JS. Epstein-Barr viral antibodies in multifocal choroiditis and panuveitis. Am J Ophthalmol. 1987;3:659–63.

    Google Scholar 

  64. Spaide RF, Skerry JE, Yannuzzi LA, DeRosa JT. Lack of the HLA-DR2 specificity in multifocal choroiditis and panuveitis. Br J Ophthalmol. 1990;3:536–7.

    Google Scholar 

  65. Patel KH, Birnbaum AD, Tessler HH, Goldstein DA. Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. Retina. 2011;31(7):1387–91.

    PubMed  Google Scholar 

  66. Amer R, Lois N. Punctate inner choroidopathy. Surv Ophthalmol. 2011;56(1):36–53.

    PubMed  Google Scholar 

  67. Gerstenblith AT, Thorne JE, Sobrin L, Do DV, Shah SM, Foster CS. Punctate inner choroidopathy: a survey analysis of 77 persons. Ophthalmology. 2007;114:1201–4.

    PubMed  Google Scholar 

  68. Leung AK, Weisbrod DJ, Schwartz C. Intravitreal ranibizumab in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy. Can J Ophthalmol. 2010;45(3):300–1.

    PubMed  Google Scholar 

  69. Tiffin PA, Maini R, Roxburgh ST, et al. Indocyanine green angiography in a case of punctate inner choroidopathy. Br J Ophthalmol. 2002;80:90–1.

    Google Scholar 

  70. Chen SN, Hwang JF. Ocular coherence tomographic and clinical characteristics in patients of punctuate inner choroidopathy associated with zonal outer retinopathy. Ocul Immunol Inflamm. 2014;22:263–9. Posted online on 19 Dec 2013.

    PubMed  Google Scholar 

  71. Zhang X, Zuo C, Li M, Chen H, Huang S, Wen F. Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. Ophthalmology. 2013;120(12):2678–83.

    PubMed  Google Scholar 

  72. Kramer M, Priel E. Fundus autofluorescence imaging in multifocal choroiditis: beyond the spots. Ocul Immunol Inflamm. 2014;22:349–55. Posted online on 11 Dec 2013.

    CAS  PubMed  Google Scholar 

  73. Riaz KM, Jampol LM, Mirza RG. Fundus autofluorescence imaging in punctate inner choroidopathy with blind spot enlargement. Ocul Immunol Inflamm. 2012;20(6):460–3.

    PubMed  Google Scholar 

  74. Essex RW, Wong J, Fraser-Bell S, Sandbach J, Tufail A, Bird AC, Dowler J. Punctate inner choroidopathy: clinical features and outcomes. Arch Ophthalmol. 2010;128(8):982–7.

    PubMed  Google Scholar 

  75. Levy J, Shneck M, Klemperer I, Lifshitz T. Punctate inner choroidopathy: resolution after oral steroid treatment and review of the literature. Can J Ophthalmol. 2005;40(5):605–8.

    PubMed  Google Scholar 

  76. Brueggeman RM, Noffke AS, Jampol LM. Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. Arch Ophthalmol. 2002;120(7):996.

    PubMed  Google Scholar 

  77. Fong KC, Thomas D, Amin K, Inzerillo D, Horgan SE. Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy. Eye (Lond). 2008;22(4):528–33.

    CAS  Google Scholar 

  78. Chan WM, Lai TY, Lau TT, Lee VY, Liu DT, Lam DS. Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. Retina. 2008;28(1):71–80.

    PubMed  Google Scholar 

  79. Lowder C, Belfort Jr R, Lightman S, Foster CS, Robinson MR, Schiffman RM, Li XY, Cui H, Whitcup SM. Ozurdex huron study group. Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol. 2011;129(5):545–53.

    PubMed  Google Scholar 

  80. Kempen JH, Altaweel MM, Holbrook JT, Jabs DA, Louis TA, Sugar EA, Thorne JE. Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. Ophthalmology. 2011;118(10):1916–26.

    PubMed Central  PubMed  Google Scholar 

  81. Turkcuoglu P, Chang PY, Rentiya ZS, Channa R, Ibrahim M, Hatef E, Sophie R, Sadaka A, Wang J, Sepah YJ, Do DV, Foster CS, Nguyen QD. Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. Ocul Immunol Inflamm. 2011;19(4):286–92.

    CAS  PubMed  Google Scholar 

  82. Ip M, Gorin MB. Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. Am J Ophthalmol. 1996;122(4):594–5.

    CAS  PubMed  Google Scholar 

  83. Nussenblatt RB, Coleman H, Jirawuthiworavong G, et al. The treatment of multifocal choroiditis associated choroidal neovascularization with sirolimus (rapamycin). Acta Ophthalmol Scand. 2007;85:230–1.

    PubMed  Google Scholar 

  84. Cirino AC, Mathura Jr JR, Jampol LM. Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. Retina. 2006;26(9):1091–2.

    PubMed  Google Scholar 

  85. Mangat SS, Ramasamy B, Prasad S, Walters G, Mohammed M, Mckibbin M. Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. Semin Ophthalmol. 2011;26(1):1–3.

    PubMed  Google Scholar 

  86. Chatterjee S, Gibson JM. Photodynamic therapy: a treatment option in choroidal neovascularisation secondary to punctate inner choroidopathy. Br J Ophthalmol. 2003;87(7):925–7.

    PubMed Central  CAS  PubMed  Google Scholar 

  87. Ehlers JP, Maldonado R, Sarin N, Toth CA. Treatment of non-age-related macular degeneration submacular diseases with macular translocation surgery. Retina. 2011;31(7):1337–46.

    PubMed  Google Scholar 

  88. Jampol LM, Sieving PA, Pugh D, et al. Multiple evanescent white dot syndrome. I. Clinical findings. Arch Ophthalmol. 1984;102:671–4.

    CAS  PubMed  Google Scholar 

  89. Borruat FX, Herbort CP, Spertini F, et al. HLA typing in patients with multiple evanescent white dot syndrome (MEWDS). Ocul Immunol Inflamm. 1998;6:39–41.

    CAS  PubMed  Google Scholar 

  90. Gross NE, Yannuzzi LA, Freund KB, Spaide RF, Amato GP, Sigal R. Multiple evanescent white dot syndrome. Arch Ophthalmol. 2006;124(4):493–500.

    PubMed  Google Scholar 

  91. Joseph A, Rahimy E, Freund KB, Sorenson JA, Sarraf D. Fundus autofluorescence and photoreceptor bleaching in multiple evanescent white dot syndrome. Ophthalmic Surg Lasers Imaging Retina. 2013;44(6):588–92.

    PubMed  Google Scholar 

  92. Hangai M, Fujimoto M, Yoshimura N. Features and function of multiple evanescent white dot syndrome. Arch Ophthalmol. 2009;127(10):1307–13.

    PubMed  Google Scholar 

  93. Hua R, Chen K, Liu LM, Liu NN, Chen L, Teng WP. Multi-modality imaging on multiple evanescent white dot syndrome-A Spectralis Study. Int J Ophthalmol. 2012;5(5):644–7.

    PubMed Central  PubMed  Google Scholar 

  94. Sieving PA, Fishman GA, Jampol LM, Pugh D. Multiple evanescent white dot syndrome. II. Electrophysiology of the photoreceptors during retinal pigment epithelial disease. Arch Ophthalmol. 1984;102:675–9.

    CAS  PubMed  Google Scholar 

  95. Palestine AG, Nussenblatt RB, Parver LM, Knox DL. Progressive subretinal fibrosis and uveitis. Br J Ophthalmol. 1984;68:667–73.

    PubMed Central  CAS  PubMed  Google Scholar 

  96. Symeonidis C, Dastiridou A, Konidaris V, Brazitikos P, Androudi S. Subretinal fibrosis and uveitis: a spectral domain OCT study of its evolution and the minimal therapeutic effect of the off-label treatment with ranibizumab. Ocul Immunol Inflamm. 2014;22:497–500.

    CAS  PubMed  Google Scholar 

  97. Monson DM, Smith JR. Acute zonal occult outer retinopathy. Surv Ophthalmol. 2011;56(1):23–35.

    PubMed  Google Scholar 

  98. Gass JD, Agarwal A, Scott IU. Acute zonal occult outer retinopathy: a long-term follow-up study. Am J Ophthalmol. 2002;134(3):329–39.

    PubMed  Google Scholar 

  99. Kuniyoshi K, Sakuramoto H, Nakao Y, Matsumoto C, Shimomura Y. Two types of acute zonal occult outer retinopathy differentiated by dark- and light-adapted perimetry. Jpn J Ophthalmol. 2014;58:177–87.

    CAS  PubMed  Google Scholar 

  100. Chai Y, Yamazaki H, Fujinami K, Tsunoda K, Yamamoto S. A case of acute zonal occult outer retinopathy with abnormal pattern visual evoked potentials. Clin Ophthalmol. 2011;5:1235–41.

    PubMed Central  PubMed  Google Scholar 

  101. Krill AE, Deutman AF. Acute retinal pigment epitheliitis. Am J Ophthalmol. 1972;74:193–205.

    CAS  PubMed  Google Scholar 

  102. Baillif S, Wolff B, Paoli V, Gastaud P, Mauget-Faÿsse M. Retinal fluorescein and indocyanine green angiography and spectral-domain optical coherence tomography findings in acute retinal pigment epitheliitis. Retina. 2011;31(6):1156–63.

    PubMed  Google Scholar 

  103. Hsu J, Fineman MS, Kaiser RS. Optical coherence tomography findings in acute retinal pigment epitheliitis. Am J Ophthalmol. 2007;143:163–5.

    PubMed  Google Scholar 

  104. Cho HJ, Lee DW, Kim CG, Kim JW. Spectral domain optical coherence tomography findings in acute retinal pigment epitheliitis. Can J Ophthalmol. 2011;46(6):498–500. [Medline].

    PubMed  Google Scholar 

  105. Jee Wook Kim, Sun Young Jang, Tae Kwann Park, Young-Hoon Ohn. Short-term clinical observation of acute retinal pigment epitheliitis using spectral-domain optical coherence tomography. Korean J Ophthalmol. 2011;25(3):222–4.

    Google Scholar 

  106. Li D, Kishi S. Restored photoreceptor outer segment damage in multiple evanescent white dot syndrome. Ophthalmology. 2009;116:762–70.

    PubMed  Google Scholar 

  107. Amin P, Cox TA. Acute macular neuroretinopathy. Arch Ophthalmol. 1998;116:112–3.

    CAS  PubMed  Google Scholar 

  108. Fawzi AA, Pappuru RR, Sarraf D, et al. Acute macular neuroretinopathy: long term insights revealed by multimodal imaging. Retina. 2012;32:1500–13.

    PubMed  Google Scholar 

  109. Baumuller S, Holz FG. Early spectral-domain optical coherence tomography findings in acute macular neuroretinopathy. Retina. 2012;32:409–10.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jyotirmay Biswas .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer India

About this chapter

Cite this chapter

Biswas, J., Annamalai, R. (2016). White Dot Syndromes. In: Biswas, J., Majumder, P. (eds) Uveitis: An Update. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2295-8_18

Download citation

  • DOI: https://doi.org/10.1007/978-81-322-2295-8_18

  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-2294-1

  • Online ISBN: 978-81-322-2295-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics