Microbes in Production of Fine Chemicals (Antibiotics, Drugs, Vitamins, and Amino Acids)

  • Sanjai Saxena


Fine chemicals are single pure substances that are produced in small to medium quantities and have a high value (>US$10/kg). They are synthesized via multi-step batch chemical or biotechnological processes. Fine chemicals consist of organic aromatic compounds, organic amines, proteogenic/non-proteogenic amino acids, carbohydrates, heteroaromatic compounds, and saturated and unsaturated fatty acids, uses for which are found in the pharmaceutical, specialty chemical, agricultural, and cosmeceutical industries (Pollack 2007) (Fig. 8.1).


Artemisinic Acid Musk Fragrance Organic Aromatic Compound Penicillium Brevicompactum Classical Strain Improvement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Selected Reading

  1. Allegrone G, Barbeni M, Cardillo R, Fuganti C, Grasselli P, Miele A, Pisciotta A (1991) On the steric course of the microbial generation of (Z6)-gamma-dodecenolactone from (10R,S) 10-hydroxyoctadeca-(E8,Z12)-dienoic acid. Biotechnol Lett 13:765–768Google Scholar
  2. Allison A (2001) The possible role of vitamin K deficiency in pathogenesis of Alzheimer’s disease and in augmenting the brain damage associated with cardiovascular disease. Med Hypothesis 57(2):151–155Google Scholar
  3. Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J, Spiteller M, Qazi GN (2006) Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin. Can J Microbiol 52:189–196PubMedGoogle Scholar
  4. Anke T, Oberwinkler F, Steglich W, Schramm G (1977) The strobilurins – new antifungal antibiotics from the basidiomycete Strobilurus tenecellus. J Antibiot 30:806–810PubMedGoogle Scholar
  5. Attala MM, El-khrisy EAM, Youssef YA, Asem MA (2011) Production of textile reddish brown dyes by fungi. Malays J Microbiol 7(1):33–40Google Scholar
  6. Bennett JW, Chung KT (2001) Alexander Fleming and the discovery of penicillin. Adv Appl Microbiol 49:163–184PubMedGoogle Scholar
  7. Blanche F, Cameron B, Crouzet J, Debussche L, Levy-Schil S, Thibaut D (1998) Polypeptides involved in the biosynthesis of cobalamines and/or cobamides, DNA sequences coding for these polypeptides, and their preparation and use. Eur. Patent 0516647 B1Google Scholar
  8. Borel JF, Feurer C, Gubler HU, Stahelin H (1976) Biological effects of cyclosporin A: a new anti-lymphocytic agents. Agents Action 6(4):458–475Google Scholar
  9. Burton JP, Chilcott CN, Moore CJ, Speiser G, Tagg GR (2006) A preliminary study of the effect of probiotic Streptococcus salivarinus K12 in oral malodour parameters. J Appl Microbiol 100(4):754–764PubMedGoogle Scholar
  10. Cao L, Huang J, Li J (2007) Fermentation conditions of Sinopodophyllum hexandrum endophytic fungus on production of podophyllotoxin. Food Ferment Ind 33:28–32Google Scholar
  11. Carballo-Cardenas EC, Tuan PM, Janssen M, Wijffels RH (2003) Vitamin E (α-tocopherol) production by marine microalgae Dunaliella tertiolecta and Tetraselmis suecica in batch cultivation. Biomol Eng 20(4):139–147Google Scholar
  12. Caruso M, Colombo AL, Crespi-Perellino A, Fedeli L, Pavesi A, Quaroni S, Saracchi M, Ventrella G (2000) Studies on a strain of Kitasatophora sp. paclitaxel producer. Ann Microbiol 50:89–102Google Scholar
  13. Chakravarthi BVSK, Das P, Surendranath K, Karande AA, Jayabaskaran C (2008) Production of paclitaxel by Fusarium solani isolated from Taxus celebica. J Biosci 33:259–267PubMedGoogle Scholar
  14. Chang MCY, Keasling JD (2006) Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol 2:674–681PubMedGoogle Scholar
  15. Cheetham PSJ (1993) The use of biotransformation for the production of flavours and fragrances. Trends Biotechnol 11:478–488Google Scholar
  16. Cheung AU, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, Hu H, Vieth R, Thompson L, Jamal S, Josse R (2008) Vitamin K supplementation in post menopausal women with osteopenia (Ekcotrial): a randomized controlled trial. PLoS Med 5(10):1461–1472Google Scholar
  17. Cooper R, Bush K, Principe PA, Trejo WH, Weels JS, Sykes RB (1983) Two new monobactam antibiotics produced by Flexibacter sp. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot 36(10):1252–1257PubMedGoogle Scholar
  18. Dahlen T, Hauck T, Wein M, Schwab W (2001) 2, 5-dimethyl-4-hydroxy-3(2H) - furanone as a secondary metabolite from D-fructose-1, 6-diphosphate metabolism by Zygosacharomyces rouxii. J Biosci Bioeng 91:352–358PubMedGoogle Scholar
  19. Dai W, Tao W (2008) Preliminary study on fermentation conditions of taxol-producing endophytic fungus. Chem Ind Eng Prog 27:883–886Google Scholar
  20. De Kwaadsteniet M, van Reenen C, Dicks L (2010) Evaluation of nisin F in the treatment of subcutaneous skin infections as monitored by using bioluminescent strain of Staphylococcus aureus. Probiotics Antimicrob Proteins 2(2):61–65Google Scholar
  21. Deng BW, Liu KH, Chen WQ, Ding XW, Xie XC (2009) Fusarium solani, Tax-3, a new endophytic taxol-producing fungus from Taxus chinensis. World J Microbiol Biotechnol 25:139–143Google Scholar
  22. Deresinski SC, Stevens DA (2003) Caspofungin. Clin Infect Dis 36:1445–1447PubMedGoogle Scholar
  23. Ec C-C, Tuan PM, Janssen M, Wijffels RN (2003) Vitamin E (α-tocopherol) production by the marine microalgae Dunaliella tertiolecta and Tetraselmis suecica in batch cultivation. Biomol Eng 20(4–6):139–147Google Scholar
  24. Endo A, Kuroda M, Trujita HY (1976) ML-236A and ML-236C: new inhibitors of cholesterol genesis produced by Penicillium citrinum. J Antibiot 29:1346–1348PubMedGoogle Scholar
  25. Engels B, Dahm P, Jennewein S (2008) Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab Eng 10:201–206PubMedGoogle Scholar
  26. Ensley DB, Ratzkin JB, Osslund DT, Simon JM (1983) Expression of naphthalene oxidation genes in Escherichia coli results in the biosynthesis of indigo. Science 222:167–169PubMedGoogle Scholar
  27. Eyberger AL, Dondapati R, Porter JR (2006) Endophyte fungal isolates from Podophyllum peltatum produces podophyllotoxin. J Nat Prod 69:1121–1124PubMedGoogle Scholar
  28. Fabre CE, Santrre AL, Loret MD, Beberian R, Paralleux A, Gena G, Blanc PJ (1993) Production and food application of the red pigment of Monascus ruber. J Food Sci 58:1099–1103Google Scholar
  29. Farbood MI, Morris JA, Sprecker MA, Beinkowski LJ, Miller KP, Vock MH, Hagedorn ML (1990) Flavoring with mixtures of lactones US Patent 4,960,597Google Scholar
  30. Feling RH, Buchanan GO, Mincer TJ, Kauffman CA, Jensen PR, Fenical W (2003) Salinosporamide A: a highly cytotoxic proteasome inhibitor from novel microbial source, marine bacterium of new genus Salinospora. Angew Chem Int Engl 42:355–357Google Scholar
  31. Floss HG, Lee S, Tornus I (2000) Valiolone, a method of preparing it and its use to prepare acarbose and voglibose. US Patent no. 6150568Google Scholar
  32. Fradenhagen A, Tamura SY, Kenny PTM, Komura H, Naya Y, Nakanishi K, Sugiura J, Kita H (1987) Andrimid, a new peptide antibiotic produced by an intracellular bacterial symbiont from brown plant hopper. J Am Chem Soc 109(14):4409–4411Google Scholar
  33. Fuller AT, Mellaros G, Woolford M, Banks GT, Barrow KD, Chain EB (1971) Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Nature 234:416–417PubMedGoogle Scholar
  34. Gangadevi V, Muthumary J (2008) Taxol, an anticancer drug produced by endophytic fungus Bartaliana robillardoides Tassi, isolated from the medicinal plant Aegle marmelos Correa ex Roxb. World J Microbiol Biotechnol 24(5):712–724Google Scholar
  35. Gangadevi V, Muthumary J (2009) A novel endophytic Taxol producing Chaetomella raphigera isolated from the medicinal plant Terminalia arjuna. Appl Biochem Biotechnol 158(3):675–684PubMedGoogle Scholar
  36. Giri AV, Anandkumar N, Muthukumaran G, Pennathur G (2004) A novel medium for the enhanced cell growth and production of prodigiosin from Serratia marcescens isolated from soil. BMC Microbiol 4:1–10Google Scholar
  37. Guo B, Li H, Zhang L (1998) Isolation of the fungus producing vinblastine. J Yunnan Univ (Nat Sci Ed) 20:214–215Google Scholar
  38. Gurudatt PS, Priti V, Shweta S, Ramesha BT, Ravikanth G, Vasudeva R, Amna T, Deepika S, Ganeshaiah KN, UmaShaanker R, Puri S, Qazi N (2010) Camptothecin production and negative relationship between hyphal biomass and camptothecin content in endophytic strains of Nothapodytes nimmoniana Grahm (Icecinaceae). Curr Sci 98(8):1006–1010Google Scholar
  39. Hanefeld M, Fischer S, Schulze J, Spengler M, Waagenar H, Schollberg K, Fuker K (1991) Therapeutic potentials of acarbose as a first line drug in NIDDM insufficiently treated with diet alone. Diabetes Care 14(8):732–737PubMedGoogle Scholar
  40. Hannibal L, Lorquin J, D’ortoli NA, Chaintreuil C, Masson-Boivin C, Dreyfus B, Giruad E (2000) Isolation and characterization of canthaxanthin biosynthesis genes from the photosynthetic bacterium Bradyrhizobium sp. strain ORS278. J Bacteriol 182(13):3850–3853PubMedCentralPubMedGoogle Scholar
  41. Hirao T, Nakano T, Azuma T, Sugimoto M, Nakanishi T (1989) L-Lysine production in continuous culture of an L-Lysine hyperproducing mutant of Corynebacterium glutamicum. Appl Microbiol Biotechnol 32:269Google Scholar
  42. Huang S, Bjornsti MA, Houghton PJ (2003) Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2:222–232PubMedGoogle Scholar
  43. Hughes PE, Tove SB (1982) Occurrence of α-tocopherol quinone and α-tocopherol quinol in microorganisms. J Bacteriol 151:1397–1402PubMedCentralPubMedGoogle Scholar
  44. Irschik KH, Reichenbach H, Hofele G, Jansen R (2007) The thuggacins, novel antibacterial macrolides from Sorangium cellulosum against selected gram positive bacteria. J Antibiot 60(12):733–738PubMedGoogle Scholar
  45. Jabes D, Brunati C, Candiani GP, Rwa S, Romano G, Donadio S (2011) Efficacy of the new antibiotic NAI-107 in experimental infections induced by multidrug resistant gram positive pathogens. Antimicrob Agents Chemother 55(4):1671–1676PubMedCentralPubMedGoogle Scholar
  46. Ju Z, Wang J, Pan S (2009) Isolation and preliminary identification of the endophytic fungi which produce Hupzine A from four species in Hupziaceae and determination of Huperzine A by HPLC. Fudan Univ J (Med Sci Ed) 36:445–449Google Scholar
  47. Kamada Y, Asano N, Yoshikawa T, Matsui K, Horii S, Fukase H (1984) Valiolamine – a new alpha glucosidase inhibiting aminocyclitol produced by S. hygroscopicus. J Antibiot 37(11):1301–1307Google Scholar
  48. Kapfer GF, Berger RG, Draweti F (1989) Production of 4-decanolide by semicontinuous fermentation of Tyromyces sambuceus. Biotechnol Lett 11:561–566Google Scholar
  49. Katayama N, Fukusami S, Funabashi Y, Iwahi T, Ono H (1993) TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin resistant Staphylococcus aureus: taxonomy fermentation and biological activity. J Antibiot 46:606–613PubMedGoogle Scholar
  50. Keri V, Csorvasi A, Aronhime J (2003) Preparation of orlistat and orlistat crystalline forms. US application no. US2003/149095 A1Google Scholar
  51. Kerkeenar A, Schemedding DJM, Berg J (1993) Method of preparation of p-metha-8-thiol-3-one. US Patent 5182194Google Scholar
  52. Kim PI, Sohng JK, Sung C, Joo HS, Kim EM, Yamaguchi T, Park D, Kim BG (2010) Characterization and structure identification of antimicrobial peptide Hominicin produced by Staphylococcus hominis MBBL-29. Biochem Biophys Res Commun 399(2):133–138PubMedGoogle Scholar
  53. Kimura E (2003) Metabolic engineering of glutamate production. In: Scheper T, Faurie R, Thommel J (eds) Advances in biochemical engineering/biotechnology, vol 79. Springer, Berlin/Heidelberg/New York, pp 37–57Google Scholar
  54. Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H (1987) FK-506, n novel immunosuppressant isolated from Streptomyces species I. Fermentation, isolation and physicochemical and biological characterization. J Antibiot 40(3):1249–1255PubMedGoogle Scholar
  55. Kinoshita S (1985) Glutamic acid bacteria. In: Demain AL, Solomon NA (eds) Biology of industrial microorganisms. Benjamin/Cummings, Menlo Park, pp 115–142Google Scholar
  56. Kong MC, Lee PC (2011) Metabolic engineering of menaquinone-8-pathway of E. coli as a microbial platform for vitamin K production. Biotechnol Bioeng 108(8):1997–2002PubMedGoogle Scholar
  57. Kosuge T, Kamiya H (1962) Tetramethylpyrazine: a Bacillus subtilis growth factor. Nature 193:776PubMedGoogle Scholar
  58. Kour A, Shawl AS, Rehman S, Sultan P, Qazi PH, Suden P, Khajuria RK, Verma V (2008) Isolation and identification of an endophytic strain of Fusarium oxysporum producing podophyllotoxin from Juniperus recurva. World J Microbiol Biotechnol 24:1115–1121Google Scholar
  59. Kruszewska D, Sahl HG, Bierbaum G, Pag G, Hynes SO, Ljungh A (2004) Mersacidin eradicates methicillin resistant Staphylococcus aureus (MRSA) in mouse rhinitis model. J Antimicrob Chemother 34(3):648–653Google Scholar
  60. Kumaran RS, Muthumary J, Hur BK (2008) Production of taxol from Phyllosticta spinarum, an endophytic fungus of Cupressus sp. Eng Life Sci 8:438–446Google Scholar
  61. Kumaran RS, Choi YK, Lee S, Jeon HJ, Jung H, Kim HJ (2012) Isolation of taxol, an anticancer drug produced by the endophytic fungus Phoma betae. Afr J Biotechnol 11(4):950–960Google Scholar
  62. Kusari S, Zuhlke S, Spiteller M (2009) An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. J Nat Prod 72:2–7PubMedGoogle Scholar
  63. Li JY, Strobel GA, Sidhu R, Hess WM, Ford EJ (1996) Endophytic taxol-producing fungi from bald cypress, Taxodium distichum. Microbiology 142:2223–2226PubMedGoogle Scholar
  64. Li JY, Sidhu RS, Ford EJ, Long DM, Hess WM, Strobel GA (1998) The induction of taxol production in the endophytic fungus-Periconia sp. from Torreya grandifolia. J Ind Microbiol Biotechnol 20:259–264Google Scholar
  65. Lim SH, Choi JS, Park EY (2001) Microbial production of riboflavin using riboflavin overproducers, Ashbya gossypii, Bacillus subtilis, and Candida famate: an overview. Biotechnol Bioprocess Eng 6:75–88Google Scholar
  66. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, Booth SL, Volpe JJ, Rosenberg PA (2003) Novel role of vitamin K in preventing oxidative injury to oligodendrocytes and neurons. J Neurosci 23(13):5816–5826PubMedGoogle Scholar
  67. Li W, Zhou J, Lin Z, Hu Z (2007) Study on fermentation condition for production of huperzine A from endophytic fungus 2F09P03B of Huperzia serrata. Chin Med Biotechnol 2:254–259Google Scholar
  68. Li Y, Qui NE, Yin H, Peng H (2011) Isolation of a podophyllotoxin producing endophytic fungus from Sinopodophyllum hexandrum and the anti-S180 sarcoma activity of its fermentation broth in mice. Acad J Second Mil Med Univ. doi: 10.3724/ SP.J.1008.2011.00012 Google Scholar
  69. Liu JM, Ni MY, Fan JF, Tu YY, Wu ZH, Wu YL, Chou WS (1979) Structure and reaction of Arteannuin. Acta Chim Sin 37:129–143Google Scholar
  70. Liu K, Ding X, Deng B, Chen W (2009) Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis. J Ind Microbiol Biotechnol 36:1171–1177PubMedGoogle Scholar
  71. Liu K, Ding X, Deng B, Chen W (2010) 10-hydroxycamptothecin produced by new endophytic Xylaria sp. M 20, from Camptotheca acuminata. Biotechnol Lett 32(5):689–693PubMedGoogle Scholar
  72. Lurie Y, Loebstein R, Kurnik D, Almog S, Halkin H (2010) Warfarin and vitamin K intake in the era of pharmacogenomics. Br J Clin Pharmacol 70(2):164–170PubMedCentralPubMedGoogle Scholar
  73. Majumdar SK, Bose SK (1958) Mycobacillin, a new antifungal antibiotic produced by Bacillus subtilis. Nature 181(4602):134–135PubMedGoogle Scholar
  74. Mansoroi K, Khaurin P, Lohetaroenkal W, Werner RG, Gotz F, Monosroi A, Monosroi J (2010) Transdermal adsorption enhancement through rat skin of Gallidermin loaded niosomes. Int J Pharm 392(1–2):304–310Google Scholar
  75. Martens, J.H., Barg H., Warren M and Jahn D. (2002) : Microbial production of vitamin B12 Appl Microbiol Biotechnol 58:275–285Google Scholar
  76. Miao Z, Wang Y, Yu X, Guo B, Tang K (2009) A new endophytic taxane production fungus from Taxus chinensis. Appl Biochem Microbiol 45:81–86Google Scholar
  77. Murray BE (1981) Cephalosporins. Ann Rev Med 32:559–581PubMedGoogle Scholar
  78. Mutabingwa TK (2005) Artemisinin-based combination therapies (ACTs) best hope for malaria treatment but inaccessible to the needy! Acta Trop 95:305–315PubMedGoogle Scholar
  79. Nadeem M, Ram M, Alam M, Ahmad MM, Qurainy A, Khan S, Abdin MZ (2012) Fusarium solani P1, a new endophytic podophyllotoxin producing fungus from the roots of Podophyllum hexandrum. Afr J Microbiol Res 6(10):2493–2499Google Scholar
  80. Ogbonna JC, Tomiyamal S, Tanaka H (1998) Heterotrophic cultivation of Euglena gracilis Z for efficient production of α-tocopherol. J Appl Phycol 10:67–74Google Scholar
  81. Ohnuma S, Suzuki M, Nishino T (1994) Archaebacterial ether linked lipid biosynthetic gene. Expression, cloning, sequencing and characterization of geranygerany-diphosphate synthase. J Biol Chem 269:14792–14797PubMedGoogle Scholar
  82. Pandi M, Kumaran RS, Choi YK, Kim HJ, Muthumary J (2011) Isolation and detection of taxol, an anticancer drug produced by L. theobromae, an endophytic fungus in medicinal plant Morinda citrifolia. Afr J Biotechnol 10(8):1428–1435Google Scholar
  83. Perkins JB, Sloma A, Hermann J, Theriault K, Zachgo E, Erdenberger T, Hannett N, Chatterjee NP, Williams V II, Rufo GA Jr, Hatch R, Pero J (1999) Genetic engineering of Bacillus subtilis for commercial production of riboflavin. J Ind Microb Biotechnol 22:8–18Google Scholar
  84. Perlman D (1979) Microbial process of Riboflaviun Production In: Peppler JH, Perlman D (eds) Microbial process of riboflavin production in microbial technology, vol 1, 2nd edn. Academic, New York, pp 521–527Google Scholar
  85. Piper C, Draper LA, Cotter PD, Ross RP, Hill C (2009) A comparison of the activities of Lacticin 3147 and Nisin against drug resistant Staphylococcus aureus and Enterococcus species. J Antimicrob Chem 64(3):546–551Google Scholar
  86. Piper C, Carey CG, Hill C, Cotter PD, Ross RP (2012) The lantibiotic Lacticin 3147 prevents systemic spread of Staphylococcus aureus in Murine infection model. Int J Microbiol. doi: 10.1155/2012/806230 PubMedCentralPubMedGoogle Scholar
  87. Pollack P (2007) Fine chemicals: the industry and the business. Wiley, Hoboken. ISBN 978-0-470-05075-0Google Scholar
  88. Powls R, Redfearn ER (1967) The tocopherols of blue-green algae. Biochem J 104:24C–26CGoogle Scholar
  89. Priefert H, Rabenhorst J, Steinbüchel A (2001) Biotechnological production of vanillin. Appl Microbiol Biotechnol 56:296–314PubMedGoogle Scholar
  90. Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from Nothapodytes foetida that produces camptothecin. J Nat Prod 68:1717–1719PubMedGoogle Scholar
  91. Puri SC, Nazir A, Chawla R, Arora R, Riyaz-ul-Hasan S, Amna T, Ahmed B, Verma V, Singh S, Sagar R, Sharma A, Kumar R, Sharma RK, Qazi GN (2006) The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin ligans. J Biotechnol 122:494–510PubMedGoogle Scholar
  92. Qi Q, Hao M, Ng W, Slater SC, Baszis SR, Weiss JD, Valentine HE (2005) Application of the Synechococcus nirA promoter to establish an inducible expression system for engineering the Synechocystis tocopherol pathway. Appl Environ Microbiol 71:5678–5684PubMedCentralPubMedGoogle Scholar
  93. Rea MC, Sit CS, Clayton E, O’Conner PM, Whittal RM, Zheng J, Vederas JC, Ross RP, Hill C (2010) Thuricin CD a post translationally modified bacteriocin with narrow spectrum of activity against Clostridium difficale. PNAS. doi: 10.1073/pnas0.913444107 Google Scholar
  94. Rehman S, Shawl AS, Kour A, Andrabi R, Sudan P, Sultan P, Verma V, Qazi GN (2008) An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin. Appl Biochem Microbiol 44:203–209Google Scholar
  95. Rehman S, Shawl AS, Kour A, Sultan P, Ahmad K, Khajuria R, Qazi GN (2009) Comparative studies and identification of Camptothecin produced by an endophyte at shake flask and bioreactor. Nat Prod Res 23(11):1050–1057PubMedGoogle Scholar
  96. Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KN, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MCY, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940–943. doi: 10.1038/nature04640 PubMedGoogle Scholar
  97. Rommele G, Traxler P, Wehrli W (1983) Papulacandins- the relationship between chemical structure and glucan synthesis in yeast. J Antibiot 36(11):1539–1542PubMedGoogle Scholar
  98. Roy S, Chatterjee S, Sen SK (2008) Biotechnological potential of Phaffia rhodozyma. J Appl Biosci 5:115–122Google Scholar
  99. Sardaryan E (2002) Strain of the microorganism Penicillium oxalicum var. armeniaca and its application. US Patent 6,340,586 B1Google Scholar
  100. Sasse F, Boehlendorf B, Hermann M, Kunze B, Forche E, Steinmetz H, Hoelfe G, Reinchenbach H (1999) Melithiazols, a new b-methoxyacrylate inhibitors in respiratory chain isolated from Myxobacteria. J Antibiot 52:721–729PubMedGoogle Scholar
  101. Schatz A, Bugie E, Waksman SA (1973) Selman Abraham Waksman, Ph.D, 22 July 1888-16 August 1973. Streptomycin reported. Ann Int Med 79:678PubMedGoogle Scholar
  102. Sharma S, Gupta C, Aggarwal S, Nagpal N (2012) Pigment extraction from fungus for textile dyeing. Indian J Fibre Text Res 37:68–73Google Scholar
  103. Shweta S, Zuehlke S, Ramesha BT, Priti V, Mohana Kunar P, Ravikanth G, Spiteller M, Vasudeva R, Shaanker RU (2010) Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin,10-hydroxycamptothecin and 9-methoxycamptothecin. Phytochemistry 71:117–122PubMedGoogle Scholar
  104. Silo Suh LA, Lethbridge BJ, Raffel SI, He HY, Clardy J, Handlesman J (1994) Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85. Appl Environ Microbiol 60:2023–2030PubMedCentralPubMedGoogle Scholar
  105. Smith L, Hasper H, Breukink NJ, Cerkasov J, Hillman JD, Wilson-Standford S, Orgrunty RS (2008) Elucidation of antimicrobial mechanism Mutacin 1140. Biochemistry 47:3308–3314PubMedGoogle Scholar
  106. Solit DB, Ivy SP, Kopil C, Sikorski R, Morris MJ, Slorin SF, Kelly WK, De La Cruz A, Gerley T, Heller G, Larson S, Schwartz L, Egorin MJ, Rosen N, Scher HI (2007) Phase I clinical trial of 17- Allylamino-17-demethoxy geldanamycin in patients with advanced cancer. Clin Cancer Res 13:1775PubMedCentralPubMedGoogle Scholar
  107. Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214–216PubMedGoogle Scholar
  108. Strobel G, Yang XS, Sears J, Kramer R, Sidhu RS, Hess WM (1996a) Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana. Microbiology 142:435–440PubMedGoogle Scholar
  109. Strobel GA, Hess WM, Ford E, Sidhu RS, Yang X (1996b) Taxol from fungal endophytes and issue of biodiversity. J Ind Microbiol 17:417–423Google Scholar
  110. Strobel GA, Hess WM, Li JY, Ford E, Sears J, Sidhu RS, Summerell B (1997) Pestalotiopsis guepinii, a taxol-producing endophyte of the wollemi pine, Wollemia nobilis. Aust J Bot 45:1073–1082Google Scholar
  111. Sun D, Ran X, Wang J (2008) Isolation and identification of a taxol-producing endophytic fungus from Podocrapus. Acta Microbiol Sin 48:589–595Google Scholar
  112. Sutherland R, Boon RJ, Griffin KE, Masters PJ, Slocombe B, White AR (1985) Antibacterial activity of Mupirocin (Pesudomonic acid). A new antibiotic for topical use. Antimicrob Agents Chemother 27(4):495–498PubMedCentralPubMedGoogle Scholar
  113. Taketomi H, Shoda K, Katsui G (1983) Results of screening test in tocopherols in the microbial realm. Vitamins (Japan) 57:133–138Google Scholar
  114. Umezawa H, Maeda K, Takeuchi OY (1966) New antibiotics bleomycin A and B. J Antibiot 19(5):200–209PubMedGoogle Scholar
  115. Unagul P, Wongsa P, Kittakoop P, Intamas S, Srikitikulchai S, Tanticharoen M (2005) Production of red pigments by insect pathogenic fungus Cordyceps unilateralis BCC1869. J Ind Microb Biotechnol 32(4):135–140Google Scholar
  116. Valentin HE, Qi Q (2005) Biotechnological production and application of Vitamin E: current state and prospects. Appl Microbiol Biotechnol 68:436–444PubMedGoogle Scholar
  117. Veerwal R, Wang J, Meijnen JP, Visser H, Sandmann G, van den Berg JA, van Ooyen AJJ (2007) High level production of beta-carotene in Saccharomyces cerevisiae by successive transformation of Carotenogenic genes from Xanthophyllomyces dendrorhous. Appl Environ Microbiol 73(13):4342–4350Google Scholar
  118. Venkatachalam R, Subban K, Paul MJ (2008) Taxol from Botryodiplodia theobromae (BT 115)-an endophytic fungus of Taxus baccata. J Biotechnol 136:S189–S190Google Scholar
  119. Vijaylaxmi P, Sarva Mangala D (2011) Fermentative production of L- Glutamic acid. Int J Adv Biotechnol Res 2(3):376–381Google Scholar
  120. Vismura R, Vestri S, Kusmic C, Barsanti L, Guattieri P (2003) Natural vitamin E enrichment of Artemia salina fed freshwater and microalgae. J Appl Phycol 15:75–80Google Scholar
  121. Waksman SA (1947) What is an antibiotic or an antibiotic substance? Mycologia 39(5):565–569PubMedGoogle Scholar
  122. Wang J, Li G, Lu H, Zhang Z, Huang Y, Su W (2000) Taxol from Tubercularia species strain TF5 an endophytic fungus of Taxus mairei. FEMS Microbiol Lett 193(2):249–253PubMedGoogle Scholar
  123. Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT, Sim GA (1966) Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 88:3888–3890Google Scholar
  124. Wang YT, Lo HS, Wang PH (2008) Endophytic fungi from Taxus mairei in Taiwan. First report of Colletotrichum gloesporioides as an endophyte in Taxus mairei. Bot Stud 49:39–43Google Scholar
  125. Weibel EK, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987) Lipstatin as inhibitors of pancreatic lipase produced by S. toxytricini. J Antibiot 40:1081–1085PubMedGoogle Scholar
  126. Williamson JM, Inamine E, Wilson KE, Douglas AE, Leisch JM, Schoberg GA (1985) Biosynthesis of the β-lactam antibiotic Thienamycin from S. cattaleya. J Biol Chem 260:4637–4647PubMedGoogle Scholar
  127. Yang X, Zhang L, Guo B, Guo S (2004) Preliminary study of a vincristine-producing endophytic fungus isolated from leaves of Catharanthus roseus. Chin Tradit Herb Drugs 35:79–81Google Scholar
  128. Zhang L, Guo B, Li H, Zeng S, Shao H, Gu S, Wei R (2000) Preliminary study on the isolation of endophytic fungus of Catharanthus roseus and its fermentation to produce products of therapeutic value. Chin Tradit Herb Drugs 31:805–807Google Scholar
  129. Zhang P, Zhou P, Yu L (2009) An endophytic taxol-producing fungus from Taxus media, Cladosporium cladosporioides MD2. Curr Microbiol 59:227–232PubMedGoogle Scholar
  130. Zhao K, Zhao L, Jin Y, Wei H, Ping W, Zhou D (2008) Isolation of a taxol-producing endophytic fungus and inhibiting effect of the fungus metabolites on HeLa cell. Mycosystema 27:735–744Google Scholar
  131. Zhao K, Ping W, Li Q, Hao S, Zhao L, Gao T, Zhou D (2009) Aspergillus niger var. taxi, a new species variant of taxol-producing fungus isolated from Taxus cuspidata in China. J Appl Microbiol 107:1202–1207PubMedGoogle Scholar
  132. Zhao K, Sun L, Ma X, Li X, Wang X, Ping W, Zhou D (2011) Improved taxol production in Nodulisporium sylviforme derived from inactivated protoplast fusion. Afr J Biotechnol 10(20):4175–4182Google Scholar
  133. Zhou S, Yang F, Lan S, Xu N, Hong Y (2009) Huperzine A producing conditions from endophytic fungus in Huperzia serrata. J Microbiol 29:32–36Google Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  • Sanjai Saxena
    • 1
  1. 1.Department of BiotechnologyThapar UniversityPatialaIndia

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