Strategies of Strain Improvement of Industrial Microbes

Classical and Recombinant DNA Technology in Improving the Characteristics of Industrially Relevant Microbes
  • Sanjai Saxena


Microbes produce a variety of products in very low concentrations which have been used as antibiotics, drugs, vitamins, enzymes, bulk organic compounds, polymers, amino acids, biofuels, etc. Prerequisite for efficient biotechnological processes at industrial scale requires the use of microbial strains which produce high titre of the desired product. However, this is not an inherent property of the selected microorganism(s); hence, modifications in their genetic material could possibly help in overcoming this limitation. Thus, industrially relevant microbes are subjected to a variety of treatments using physical, chemical or genetic tools to overproduce the desired metabolite and make the process cost efficient. This process of enhancing the biosynthetic capabilities of microbes to produce desired product in higher quantities is defined as microbial strain improvement.


Penicillium Chrysogenum Strain Improvement Genome Shuffling Industrial Microorganism Benzyl Penicillin Acylase 

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Copyright information

© Springer India 2015

Authors and Affiliations

  • Sanjai Saxena
    • 1
  1. 1.Department of BiotechnologyThapar UniversityPatialaIndia

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