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Strategies of Strain Improvement of Industrial Microbes

Classical and Recombinant DNA Technology in Improving the Characteristics of Industrially Relevant Microbes

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Applied Microbiology

Abstract

Microbes produce a variety of products in very low concentrations which have been used as antibiotics, drugs, vitamins, enzymes, bulk organic compounds, polymers, amino acids, biofuels, etc. Prerequisite for efficient biotechnological processes at industrial scale requires the use of microbial strains which produce high titre of the desired product. However, this is not an inherent property of the selected microorganism(s); hence, modifications in their genetic material could possibly help in overcoming this limitation. Thus, industrially relevant microbes are subjected to a variety of treatments using physical, chemical or genetic tools to overproduce the desired metabolite and make the process cost efficient. This process of enhancing the biosynthetic capabilities of microbes to produce desired product in higher quantities is defined as microbial strain improvement.

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  1. Department of Biotechnology, Thapar University, Patiala, Punjab, India

    Sanjai Saxena

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Saxena, S. (2015). Strategies of Strain Improvement of Industrial Microbes. In: Applied Microbiology. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2259-0_10

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