Abstract
The present review outlines recent advances in coacervate based research, their historical background and area of diversification. Methods of their preparation, encapsulation, theoretical overview, coacervation induced nano particle formation, applications in various fields have been covered. Chemically modified coacervates used in drug delivery research are discussed critically to evaluate the usefulness of these system in delivering bioactive molecules. From literature survey, it is realized that coacervate based research in drug delivery as well as in proto cellular biology have increased rapidly. Hence the present review is timely.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Oparin AI (1953) The origin of life, 2nd edn. Dover Publications, New York
Mansy SS et al (2008) Template-directed synthesis of a genetic polymer in a model protocell. Nature 454:122–125
Rasmussen S et al (eds) (2009) Protocells: bridging nonliving and living matter. MIT Press, Cambridge
Luisi PL (2006) The emergence of life. Cambridge University Press, Cambridge
Hargreaves WR, Deamer DW (1978) Liposomes from ionic, single-chain amphiphiles. Biochemistry 17:3759–3768
Szostak JW, Bartel DP, Luisi PL (2001) Synthesizing life. Nature 409:387–390
Meierhenrich UJ, Filippi JJ, Meinert C, Vierling P, Dworkin JP (2010) On the origin of primitive cells: from nutrient intake to elongation of encapsulated nucleotides. Angew Chem Int Ed 49:3738–3750
Dzieciol AJ, Mann S (2012) Designs for life: protocell models in the laboratory. Chem Soc Rev 41:79–85
Deamer DW, Dworkin JP (2005) Chemistry and physics of primitive membranes. Top Curr Chem 259:1–27
Apel CL, Deamer DW, Mautner MN (2002) Self-assembled vesicles of monocarboxylic acids and alcohols: conditions for stability and for the encapsulation of biopolymers. Biochim Biophys Acta 1559:1–9
Oberholzer T, Wick R, Luisi PL, Biebricher CK (1995) Enzymatic RNA replication in self-reproducing vesicles: an approach to a minimal cell. Biochem Biophys Res Commun 207:250–257
Chen IA, Szostak JW (2004) Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc Natl Acad Sci USA 101:7965–7970
Hyman AA, Simons K (2012) Cell biology. Beyond oil and water—phase transitions in cells. Science 337:1047–1049
Burgess DJ (1960) Complex coacervates of gelatine. J Phys Chem 64 1203–1210
Overbeek JTG, Voorn MJ (1957) Phase separation in polyelectrolyte solutions. Theory of complex coacervation. J Cell Comp Physiol 49(Supp I):7
Zhu TF, Adamala K, Zhang N, Szostak JW (2012) Photochemically driven redox chemistry induces protocell membrane pearling and division. Proc Natl Acad Sci USA 109:9828–9832
Adamala K, Szostak JW (2013) Competition between model protocells driven by an encapsulated catalyst. Nat Chem 5:495–501
Veis A (1961) Phase separation in polyelectrolyte solutions. II. Interaction effects. J Phys Chem 65:1798–1803
Motornov M, Roiter Y, Tokarev I, Minko S (2010) Prog Polym Sci 35:174–211
Sionkowska A, Wisniewski M, Skopinska J, Kennedy CJ, Wess TJ (2004) The photochemical stability of collagen-chitosan blends. Biomaterials 162:545–554
Schmitt C, Sanchez C, Thomas F, Hardy J (1999) Complex coacervation between h-lactoglobulin and acacia gum in aqueous media. Food Hydrocoll 13:483–496
Stewart RJ, Wang CS, Shao H (2011) Complex coacervates as a foundation for synthetic underwater adhesives. Adv Colloid Interface Sci 167:85–93
Hu Y, Jiang X, Ding Y, Ge H, Yuan Y, Yang C (2002) Biomaterials 23:3193–3201
Bungenberg de Jong HG, Kruyt HR (1929) Coacervation (partial miscibility in colloid systems). Proc K Ned Akad Wet 32:849–856
Overbeek JTG, Voorn MJ (1957) Phase separation in polyelectrolyte solutions. Theory of complex coacervation. J Cell Comp Physiol 49(1):7–26
Burgess DJ, Carless JE (1984) Microelectrophoretic studies of gelatin and acacia for the prediction of complex coacervation. J Colloid Interface Sci 98(1):1–8
Wang J, Velders AH, Gianolio E, Aime S, Vergeldt FJ, Van As H, Yan Y, Drechsler M, de Keizer A, Cohen Stuarta MA, van der Guchta J (2013) Controlled mixing of lanthanide(III) ions in coacervate core micelles. Chem Commun 3736
Seyrek E, Dubin PL, Tribet C, Gamble EA (2003) Ionic strength dependence of protein polyelectrolyte interactions. Biomacromolecules 273–282
Poon W, Pusey P, Lekkerkerker H (1996) Colloids in suspense. Phys World 55:3762
Mattison KW, Brittain IJ, Dubin PL (1995) Protein–polyelectrolyte phase boundaries. Biotechnol Prog 11:632–637
Weinbreck HS, Rollema RH (2004) Tromp, diffusivity of whey protein and gum arabic in their coacervates. Langmuir 20:6389–6395
Koga S, Williams DS, Perriman AW, Mann S (2011) Peptide–nucleotide microdroplets as a step towards a membrane-free protocell model. Nat Chem 3(9):720
Lee DW, Yun K-S, Ban H-S, Choe W, Lee SK, Lee KY (2009) J Control Rel 139:146–152
Fulton AB (1982) How crowded is the cytoplasm? Cell 30:345–347
Bakker MAE, Galema SA, Visser A (1999) Microcapsules of gelatin and carboxy methyl cellulose. European Patent Application EP 0 937 496 A2, Unilever NV, NL; Unilever PLC, GB (Bangs WE, Reineccius GA 1981)
Tiebackx FWZ (1911) Gleichzeitige Ausflockung zweier Kolloide. Chem Ind Kolloide 8:198–201
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer India
About this paper
Cite this paper
Dutta, L.P., Das, M. (2015). Coacervation—A Method for Drug Delivery. In: Gupta, S., Bag, S., Ganguly, K., Sarkar, I., Biswas, P. (eds) Advancements of Medical Electronics. Lecture Notes in Bioengineering. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2256-9_35
Download citation
DOI: https://doi.org/10.1007/978-81-322-2256-9_35
Published:
Publisher Name: Springer, New Delhi
Print ISBN: 978-81-322-2255-2
Online ISBN: 978-81-322-2256-9
eBook Packages: EngineeringEngineering (R0)