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Understanding the Interaction of Human Formin Binding Protein 4 with Formin FMN1

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Information Systems Design and Intelligent Applications

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 340))

Abstract

The proline rich formin homolog 1 (FH1) region of mouse formin FMN1 was initially reported to bind to WW domains and mediate its interaction with formin binding protein 4 (FNBP4) via the WW domain of FNBP4. However further structural, biochemical and functional details about this interaction have never been reported. The nature of the study that first reported this interaction, along with lack of further information, later created doubt about the possibility of this interaction under cellular environment. In this context, this computational study confirms the binding of mouse formin FMN1 FH1 with the 1st WW domain of FNBP4. Combined with our previous reports, this study concludes that only the 1st WW domain of FNBP4 is able to mediate its interaction with formins FH1 regions and its binding is stronger to the PPXXPP motif compared to the PPXP or PPXPP motifs, all of which are found in formin FH1 region.

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Abbreviations

FH:

Formin homology

FNBP/FBP:

Formin binding protein

FMN1:

Formin 1

mDia1:

Mouse Diaphanous homologue 1

PRL:

Proline rich ligands

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Acknowledgment

AD and SB would like to thank CSIR (India) and UGC (India) respectively for their PhD fellowships. AB and RD are supported by research grants from DBT (India) (project no. BT/PR6869/BID/7/417/2013). All the authors are thankful to the Bioinformatics Infrastructure Facility (BIF), University of Kalyani for necessary computational facilities.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, 741235, West Bengal, India

    Amit Das, Simanti Bhattacharya, Angshuman Bagchi & Rakhi Dasgupta

Authors
  1. Amit Das
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  2. Simanti Bhattacharya
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  3. Angshuman Bagchi
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  4. Rakhi Dasgupta
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Corresponding authors

Correspondence to Angshuman Bagchi or Rakhi Dasgupta .

Editor information

Editors and Affiliations

  1. University of Kalyanai, Kalyanai, West Bengal, India

    J. K. Mandal

  2. Department of Computer Science and Engineering, Anil Neerukonda Institute of Technology and Sciences, Vishakapatnam, India

    Suresh Chandra Satapathy

  3. Dean, Faculty of Engineering, Technology, University of Kalyani, Kalyani, West Bengal, India

    Manas Kumar Sanyal

  4. Engineering and Technological Studies, University of Kalyani, Kalyani, West Bengal, India

    Partha Pratim Sarkar

  5. Department Computer Science and Engineering, University of Kalyani, Kalyani, West Bengal, India

    Anirban Mukhopadhyay

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Das, A., Bhattacharya, S., Bagchi, A., Dasgupta, R. (2015). Understanding the Interaction of Human Formin Binding Protein 4 with Formin FMN1. In: Mandal, J., Satapathy, S., Kumar Sanyal, M., Sarkar, P., Mukhopadhyay, A. (eds) Information Systems Design and Intelligent Applications. Advances in Intelligent Systems and Computing, vol 340. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2247-7_12

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  • DOI: https://doi.org/10.1007/978-81-322-2247-7_12

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  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-2246-0

  • Online ISBN: 978-81-322-2247-7

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