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Numerical Study of Variable Lung Ventilation Strategies

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Systems Thinking Approach for Social Problems

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 327))

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Abstract

Mechanical ventilation is used for patients with a variety of lung diseases. Traditionally, ventilators have been designed to monotonously deliver equal-sized breaths. While it may seem intuitive that lungs may benefit from unvarying and stable ventilation pressure strategy, recently it has been reported that variable lung ventilation is advantageous. In this study, we analyze the mean tidal volume in response to different ‘variable ventilation pressure’ strategies. We found that uniformly distributed variability in pressure gives the best tidal volume as compared to that of normal, scale-free, log-normal, and linear distributions.

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References

  1. Taleb NN, Douady R (2013) Mathematical definition, mapping, and detection of (anti)fragility. Quant Financ 13(11):1677–1689

    Google Scholar 

  2. Taleb NN (2012) Antifragile: things that gain from disorder. Random House Digital, Inc., New York

    Google Scholar 

  3. Venegas JG, Harris RS, Simon BA (1998) A comprehensive equation for the pulmonary pressure-volume curve. J Appl Physiol 84(1):389–395

    Google Scholar 

  4. Brewster JF, Graham MR, Mutch WAC (2005) Convexity, Jensen’s inequality and benefits of noisy mechanical ventilation. J R Soc Interface 2(4):393–396

    Google Scholar 

  5. Official Conference Report (1999) International consensus conferences in intensive care medicine: ventilator-associated lung injury in ARDS. Intensive Care Med, 25:1444–1452

    Google Scholar 

  6. Albert RK (2012) The role of ventilation-induced surfactant dysfunction and atelectasis in causing acute respiratory distress syndrome. Am J Respir Crit Care Med 185(7):702–708

    Google Scholar 

  7. Dos Santos CC, Slutsky AS (2000) Invited review: mechanisms of ventilator-induced lung injury: a perspective. J Appl Physiol 89(4):1645–1655

    Google Scholar 

  8. Rouby J-J, Brochard L (2007) Tidal recruitment and overinflation in acute respiratory distress syndrome: yin and yang. Am J Respir Crit Care Med 175(2):104–106

    Google Scholar 

  9. Mutch WA, Eschun GM, Kowalski SE, Graham MR, Girling LG, Lefevre GR (2000) Biologically variable ventilation prevents deterioration of gas exchange during prolonged anaesthesia. Brit J Anaesth 84(2):197–203

    Google Scholar 

  10. Mutch WAC, Harms S, Lefevre GR, Graham MR, Girling LG, Kowalski SE (2000) Biologically variable ventilation increases arterial oxygenation over that seen with positive end-expiratory pressure alone in a porcine model of acute respiratory distress syndrome. Crit Care Med 28(7):2457–2464

    Google Scholar 

  11. McMullen MC, Girling LG, Graham MR, Mutch WAC (2006) Biologically variable ventilation improves oxygenation and respiratory mechanics during one-lung ventilation. Anesthesiology 105(1):91–97

    Google Scholar 

  12. Boker A, Haberman CJ, Girling L, Guzman RP, Louridas G, Tanner JR, Cheang M, Maycher BW, Bell DD, Doak GJ (2004) Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomy. Anesthesiology 100(3):608–616

    Google Scholar 

  13. Mutch WAC, Harms S, Graham MR, Kowalski SE, Girling LG, Lefevre GR (2000) Biologically variable or naturally noisy mechanical ventilation recruits atelectatic lung. Am J Respir Crit Care Med 162(1):319–323

    Article  Google Scholar 

  14. Mutch WAC, Buchman TG, Girling LG, Walker EK, McManus BM, Graham MR (2007) Biologically variable ventilation improves gas exchange and respiratory mechanics in a model of severe bronchospasm. Crit Care Med 35(7):1749–1755

    Google Scholar 

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Correspondence to Ganesh Bagler .

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© 2015 Springer India

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Yadav, R., Ghatge, M., Hiremath, K., Bagler, G. (2015). Numerical Study of Variable Lung Ventilation Strategies. In: Vijay, V., Yadav, S., Adhikari, B., Seshadri, H., Fulwani, D. (eds) Systems Thinking Approach for Social Problems. Lecture Notes in Electrical Engineering, vol 327. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2141-8_26

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  • DOI: https://doi.org/10.1007/978-81-322-2141-8_26

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  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-2140-1

  • Online ISBN: 978-81-322-2141-8

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