Stem Cell Therapy for Cardiac Tissue Regeneration Post-myocardial Infarction

  • Uksha Saini
  • Konstantinos Dean Boudoulas


Myocardial infarction typically is the result of atherosclerotic plaque rupture in a coronary artery followed by platelet aggregation and thrombus formation resulting in partial or total vessel occlusion with diminished blood flow to the myocardial tissue downstream [1]. Within minutes to hours, cardiomyocytes in the ischemic region undergo apoptosis resulting in cell death [2, 3]; this results in damaged myocardium, left ventricular dysfunction, and heart failure [4, 5]. Myocardial infarction results in substantial mortality and morbidity worldwide [6]. Currently, there are limited therapies to consistently and effectively reverse the course of this process, and the possibility to replace or restore damaged heart tissue using cell therapy is an exciting concept. Stem cells are undifferentiated and unspecialized cells found in the body that have the potential to develop into all cell types [1]. The present chapter focuses on defining various stem cells and their use for cardiac tissue regeneration post-myocardial infarction. In addition, the major challenges and drawbacks associated with their use will be discussed.


Stem Cell Left Ventricular Ejection Fraction Hepatocyte Growth Factor Human ESCs Injured Myocardium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer India 2014

Authors and Affiliations

  1. 1.Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research InstituteThe Ohio State UniversityColumbusUSA
  2. 2.Department of Medicine, Department of Cardiovascular MedicineThe Ohio State UniversityColumbusUSA

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