Stem Cell Therapy for Acute and Chronic Liver Failure

  • Meghnad G. Joshi
  • Apurva Gadgil
  • Ramesh R. Bhonde


Acute and chronic liver diseases are major causes of morbidity and mortality worldwide. Presently, orthotropic liver transplant is the only gold standard therapy available for such patients suffering from end-stage liver diseases. Availability of suitable liver for transplantation is very low. Thus, each year many patients die waiting for liver transplantation. Considering these facts, there is need of alternative or bridging therapy that will minimize mortality and morbidity of patients who are on transplant waiting list. Thus, stem cell population capable of differentiating to functional hepatocytes could be potential therapy in regenerating damaged liver. Stem cell sources such as embryonic, fetal, induced pluripotent or adult stem cells, or facilitator cells present in bone marrow-derived stem cells can mediate the regenerative process in the liver. This chapter summarizes the use of different sources of stem cells in regenerating damaged liver and an update on recent advances on the management of liver diseases using stem cells.


Embryonic Stem Biliary Atresia Acute Liver Failure Definitive Endoderm Chronic Liver Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2014

Authors and Affiliations

  • Meghnad G. Joshi
    • 1
  • Apurva Gadgil
    • 2
  • Ramesh R. Bhonde
    • 3
  1. 1.Department of Stem Cells and Regenerative MedicineD.Y. Patil UniversityKolhapurIndia
  2. 2.Stem Plus Biotech Pvt. Ltd.SangliIndia
  3. 3.School of Regenerative MedicineManipal Institute of Regenerative Medicine, Manipal UniversityBangaloreIndia

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