Overview of Pancreatic Replacement of β-Cells from Various Cell Sources

  • Subhanwita Sarkar Dey
  • Noriko Yoshida
  • Kouichi Hasegawa


Deregulation of glucose uptake leads to the metabolic disorder popularly known as diabetes. The islet β-cells are pancreatic endocrine cells that secret insulin, and the loss of these islet cells results in lower production of insulin thereby leading to hyperglycemia. Replenishment of β-cell through in vivo cell production or in vivo cell regeneration is the ongoing trend of islet cell research. Human embryonic stem cells and induced pluripotent stem cells are majorly being induced to produce insulin-producing cells. These approaches seem to be the best candidates for clinical trial. However, drawbacks such as teratoma formation, autoimmunity, and efficiency of glucose-responded insulin production are yet to be addressed. Transdifferentiation using the concept of direct reprogramming has shown another possibility of producing insulin-producing cells. Many ongoing clinical trials are using various cell sources for type I diabetes treatment. Some of the cell therapies for type I diabetes have started incorporating essential genes lacking in diabetic patients. In this context, adult progenitor cells are the least studied ones. The presence of adult pancreatic progenitor cells still remains controversial. To isolate live progenitor cells and understand the capacity of β-cell differentiation in the cells, novel progenitor markers should be identified, isolated, and characterized.


Islet Cell Islet Transplantation Human Pancreas Definitive Endoderm Human Pluripotent Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2014

Authors and Affiliations

  • Subhanwita Sarkar Dey
    • 1
  • Noriko Yoshida
    • 2
  • Kouichi Hasegawa
    • 1
    • 2
  1. 1.Institute for Stem Cell Biology and Regenerative Medicine (inStem)National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR)BangaloreIndia
  2. 2.Institute for Integrated Cell-Material Sciences (iCeMS)Kyoto UniversityKyotoJapan

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