Advertisement

Placental Umbilical Cord Whole Blood and Nuclear Disaster Management: A Possibility

  • Niranjan Bhattacharya
  • Sanjukta Bhattacharya
Chapter

Abstract

In 1958, six physicists were exposed to large doses of neutron irradiation following an accident at Veneza, Yugoslavia. They were sent to France and treated with multiple transfusions of homologous bone marrow. Four of the victims had successful temporary bone marrow grafts as part of the treatment [1]. In serious radiation injury, graft-versus-host disease (GVHD) may occur, particularly in patients who have their marrow completely ablated, but this would be difficult to detect in the first 72 h. GVHD, however, can usually be adequately treated with cord blood because of its very minor nature.

Keywords

Cord Blood Radiation Injury Nuclear Accident Human Umbilical Cord Blood Adult Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Mathe G et al (1959) Transfusions and grafts of homologous bone marrow in humans after accidental high dosage irradiation. Rev Fr Etud Clin Biol 4(3):226–238PubMedGoogle Scholar
  2. 2.
    Ende N, Lu S, Ende M, Giuliani D, Ricafort RJ, Alcid MG, Deladisma MD, Bagtas-Ricafort L (1996) Potential effectiveness of stored cord blood (non-frozen) for emergency use. J Emerg Med 14(6):673–677PubMedCrossRefGoogle Scholar
  3. 3.
    Ende N, Ponzio NM, Giuliani D, Bagga PS, Godyn J, Ende M, Athwal RS (1995) The effect of human cord blood on SJL/J mice after chemoablation and irradiation and its possible clinical significance. Immunol Invest 24(6):999–1012PubMedCrossRefGoogle Scholar
  4. 4.
    Kovalenko OA, Azzam EI, Ende N (2013) Human umbilical-cord-blood mononucleated cells enhance the survival of lethally irradiated mice: dosage and the window of time. J Radiat Res 54(6):1010–1014PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Mickelson AB, ed. (2012) Medical Consequences of Radiological and Nuclear Weapons, Textbook of Military Medicine series. Office of the Surgeon General, Department of the Army, United States of America, Falls Church, VA, and Borden Institute, Fort Detrick, Maryland, USAGoogle Scholar
  6. 6.
    Gorin NC, Fliedner TM, Gourmelon P et al (2006) Consensus conference on European preparedness for haematological and other medical management of mass radiation accidents. Ann Hematol 85(10):671–679PubMedCrossRefGoogle Scholar
  7. 7.
    American society of clinical Oncology (1994) Recommendations for use of haematopoietic colony stimulating factors: evidence based clinical practice guidelines. J Clin Oncol 12(11):2471–2508Google Scholar
  8. 8.
    Fliedner TM (2006) Nuclear terrorism: the role of haematology in coping with its health consequences. Curr Opin Hematol 13(6):436–444PubMedCrossRefGoogle Scholar
  9. 9.
    Singh VK, Shafran RL, Jackson WE 3rd, Seed TM, Kumar KS (2006) Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol 81(1):55–61PubMedCrossRefGoogle Scholar
  10. 10.
    SV K, Belyi DA et al (2011) Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data for the Chernobyl accident. Int J Radiat Biol 87(8):846–850CrossRefGoogle Scholar
  11. 11.
    Clarke T (2002) Newborns might help malaria kids—blood from umbilical cords could treat anemia caused by tropical disease. Available at: http://www.nature.com/nsu/021111/021111-11html
  12. 12.
    Bhattacharya N (2004) Placental umbilical cord whole blood transfusion. J Am Coll Surg 199(2):347–348PubMedCrossRefGoogle Scholar
  13. 13.
    Bhattacharya N, Bandopadhyay T, Bhattacharya M, Bhattacharya S. Do not discard 99.99 % of the human placental umbilical cord blood for the sake of stem cells only. Available at: http://bmj.com/cgi/eletters/323/7304/60#16874. Accessed 5 Oct 2001
  14. 14.
    Bhattacharya N, Bandyopadhyay T, Bhattacharya M, Bhattacharya S. Immunization and fetal cell /tissue transplant: a new strategy for geriatric treatment. Available at: http://bmj.com/cgi/eletters/323/7320/1025/b#21055. Accessed 6 Apr 2002
  15. 15.
    Bhattacharya N (2008) Study of the utility of placental cord blood in meeting the transfusion needs of beta-thalassaemic patients. Reg Health Forum 12(2):16–27Google Scholar
  16. 16.
    Bhattacharya N. The safe use of placental umbilical cord whole blood transfusion in patients suffering with anemia and thalassemia in under-resourced regions of the world. Available at: http://bmj.com/cgi/eletters/321/7269/1117#62372. Accessed 9 June 2004
  17. 17.
    Bhattacharya N. Umbilical cord whole blood transfusion in HIV patients with anemia and emaciation. Available at: http://bmj.com/cgi/eletters/327/7414/562-a#59738. Accessed 17 May 2004
  18. 18.
    Bhattacharya N. A preliminary study report on placental umbilical cord blood transfusion in victims of anemia with leprosy in under-resourced regions of the world. Available at: http://bmj.comcgi/eletters/328/7454/1447/=63828. Accessed 22 June 2004
  19. 19.
    Bhattacharya N. Umbilical cord whole blood transfusion: a suggested strategy to combat blood scarcity in Ireland. Available at: http://bmj.com/cgi/eletters/324/7330/134/c#19096. Accessed 27 Jan 2002
  20. 20.
    Bhattacharya N. Utilization of a genuine blood substitute: a suggestion to the medical fraternity in Iraqi hospital. Available at: http://bmj.com/cgi/eletters/326/7391/675#30850. Accessed 30 Mar 2003
  21. 21.
    Hoag H. Blood substitute from worm shows promise—hemoglobin from sea creature could replace red cells. Available at: http://www.nature.com/nsu/030602/030602-7html. Accessed 4 June 2003
  22. 22.
    Burd A et al (2011) A massive wastage of global resource. In: Bhattacharya N, Stubblefield P (eds) Regenerative medicine using pregnancy-specific biological substances. Springer, London/New York, pp 1–7Google Scholar
  23. 23.
    Chang M-DY, Polar JW, Khalile H et al (1993) Mouse placental macrophages have a decreased ability to present antigen. Proc Natl Acad Sci U S A 90:462–466PubMedCentralPubMedCrossRefGoogle Scholar
  24. 24.
    Ende N et al (2011) Emergency use of human cord blood. In: Bhattacharya N, Stubblefield P (eds) Regenerative medicine using pregnancy-specific biological substances. Springer, London/New York, pp 85–91CrossRefGoogle Scholar
  25. 25.
    Sovacool BK (2010) A critical evaluation of nuclear power and renewable electricity in Asia. J Contemp Asia 40(3):393–400CrossRefGoogle Scholar
  26. 26.
    Arm ST (2010) Nuclear energy a vital component of our energy future. In: Chemical engineering progress. American Institute of Chemical Engineers, New York, pp 27–34, ISSN0360-7275Google Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  1. 1.Department of Regenerative Medicine and Translational ScienceCalcutta School of Tropical Medicine and STM Cord Blood BankKolkataIndia
  2. 2.Department of International RelationsJadavpur UniversityKolkataIndia

Personalised recommendations