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An Outline of Haematopoietic Stem Cell Transplantation

  • Revathy Raj
Chapter

Abstract

Major strides have occurred in the field of haematopoietic stem cell transplantation over the past few decades. Patients with life threatening blood disorders like advanced leukaemia, genetic immunedeficiency and haemoglobinopathies can now be offered a curative option. Advances in graft manipulation, immune modulation and alternative donor sources such as large volunteer donor registries and umbilical cord blood stem cell banks have ensured that every patient has a donor to offer the chance of cure.

Keywords

Graft Versus Host Disease Haematopoietic Stem Cell Transplantation Haematopoietic Stem Cell Cord Blood Transplant Sinusoidal Obstruction Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Meisel R, Enczmann J, Balzer S et al (2005) Similar survival following HLA-identical sibling transplantation for standard indication in children with haematologic malignancies: a single centre comparison of mobilized peripheral blood stem cell with bone marrow transplantation. Klin Padiatr 217(3):135–141PubMedCrossRefGoogle Scholar
  2. 2.
    Pan L, Teshima T, Hill GR et al (1999) Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft -versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood 93(12):4071–4078PubMedGoogle Scholar
  3. 3.
    Richardson P, Guinan E (1999) The pathology, diagnosis and treatment of hepatic veno occlusive disease; current status and novel approaches. Br J Haematol 107:485–493PubMedCrossRefGoogle Scholar
  4. 4.
    Bearnian SI, Lee JL, Baron AB (1997) Treatment of hepatic verioocclusive disease with recombinant human tissue plasminogen activator, and heparin in 42 marrow transplant patients. Blood 89:1501–1506Google Scholar
  5. 5.
    Hale GA, Rochester RI, Heslop HE et al (2003) Haemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome. BioI Blood Marrow Transplant 9:698–705CrossRefGoogle Scholar
  6. 6.
    Ravindranath Y, Chang M, Steuber CP et al, Pediatric Oncology Group (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19(12):2101–2116Google Scholar
  7. 7.
    Alonzo TA, Wells RJ, Woods WG et al (2005) Postremission therapy for children with acute myeloid leukemia: the children’s cancer group experience in the transplant era. Leukemia 19(6):965–970PubMedCrossRefGoogle Scholar
  8. 8.
    Nemecek ER, Gooley TA, Woolfrey AB et al (2004) Outcome of allogeneic bone marrow transplantation for children with advanced acute myeloid leukemia. Bone Marrow Transplant 34(9):799–806PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Badell I, Munoz A, Ortega JJ et al, Spanish Working Party for BMT in Children (GETMON) (2005) Long-terrn outcome of allogeneic or autologous haemopoietic cell transplantation for acute lymphoblastic leukaemia in second remission in children. GETMON experience 1983–1998. Bone Marrow Transplant 35(9):895–901Google Scholar
  10. 10.
    Shah AJ, Lenarsky C, Kapoor N et al (2004) Busulfan and cyclophosphamide as a conditioning regimen for pediatric acute lymphoblastic leukemia patients undergoing bone marrow transplantation. J Pediatr Hematol Oncol 26(2):91–97PubMedCrossRefGoogle Scholar
  11. 11.
    Sharathkumar A, Saunders EF, Dror Y et al (2004) Allogeneic bone marrow transplantation vs chemotherapy for children with Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant 33(1):39–45PubMedCrossRefGoogle Scholar
  12. 12.
    Yusuf U, Frangoul HA, Gooley TA et al (2004) Allogeneic bone marrow transplantation in children with myelodysplastic syndrome or juvenile myelomonocytic leukemia: the Seattle experience. Bone Marrow Transplant 33(8):805–814PubMedCrossRefGoogle Scholar
  13. 13.
    Dini G, Cancedda R, Locatelli F, Bacigalupo A et al (2001) Unrelated donor marrow transplantation: an update of the experience of the Italian Bone Marrow Group (GITMO). Haematologica 86(5):451–456PubMedGoogle Scholar
  14. 14.
    Yumura-Vagi K, Inoue M, Sakata N et al (2005) Unrelated donor bone marrow transplantation for 100 pediatric patients: a single institute’s experience. Bone Marrow Transplant 36(4):307–313CrossRefGoogle Scholar
  15. 15.
    Sakata N, Kawa K, Kato K et al (2004) Unrelated donor marrow transplantation for congenital immunodeficiency and metabolic disease: an update of the experience of the Japan Marrow Donor Program. Int J Hematol 80(2):174–182PubMedCrossRefGoogle Scholar
  16. 16.
    Wall DA, Carter SL, Kernan NA et al, COBLT Steering Committee (2005) Busulfan! melphalan! antithymocyte globulin followed by unrelated donor cord blood transplantation for treatment of infant leukemia and leukemia in young children: the Cord Blood Transplantation study (COBLT) experience. BioI Blood Marrow Transplant 11(8): 637–646Google Scholar
  17. 17.
    Gluckman E, Rocha V (2004) Cord blood transplantation for children with acute leukaemia: a Eurocord registry analysis. Blood Cells Moi Dis 33(3):271–273CrossRefGoogle Scholar
  18. 18.
    Styczynski J, Cheung YK, Garvin J et al (2004) Outcomes of unrelated cord blood transplantation in pediatric recipients. Bone Marrow Transplant 34(2):129–136PubMedCrossRefGoogle Scholar
  19. 19.
    Lang P, Greil J, Bader P, Handgretinger R et al (2004) Long-term outcome after haploidentical stem cell transplantation in children. Blood Cells Mol Dis 33(3):281–287PubMedCrossRefGoogle Scholar
  20. 20.
    Veys P, Amrolia P, Rao K (2003) The role of haploidentic.al stem cell transplantation in the management of children with haematological disorders. Br J Haematol 123(2):193–206PubMedCrossRefGoogle Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  1. 1.Hematopoietic Stem Cell Transplantation UnitApollo Speciality HospitalsChennaiIndia

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