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Applications of PET in Management of Brain Tumors

  • Madhvi Tripathy
  • C. S. Bal
Chapter

Abstract

Brain tumors being structural lesions of the brain and their diagnosis and management are primarily dependent on computed tomography (CT) and magnetic resonance imaging (MRI), the latter being the standard method for evaluating both primary and metastatic tumors of the brain with excellent sensitivity. Positron emission tomography (PET) provides physiological information related to tumor metabolism, proliferation rate, aggressiveness, and invasiveness. It indirectly also provides information on the functional interaction of the tumor with the remaining brain. In fact, the first oncological application of PET was for the assessment of brain tumors. The state-of-the-art PET scanners available today provide excellent anato-metabolically coregistered images with the added utility of CT for attenuation correction of PET images. The future of fusion technology, which has recently been launched in global markets, is the integrated PET/MRI scanner, and the one important area which definitely stands to benefit from this technology is the brain.

Keywords

Positron Emission Tomography Brain Metastasis Primary Central Nervous System Lymphoma Radiation Necrosis Leptomeningeal Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

For Further Reading

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    Herholz K, Langen KJ, Sceipers C, et al. Brain tumors. Semin Nucl Med. 2012;42:356–70.PubMedCentralPubMedCrossRefGoogle Scholar
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    Popperl G, Gotz C, Rachinger W, et al. Value of F-18 fluoroethyltyrosine PET for the diagnosis of recurrent glioma. Eur J Nucl Med Mol Imaging. 2004;31:464–1470.CrossRefGoogle Scholar
  3. 3.
    Singhal T, Narayanan TK, Jacobs MP, Bal C, Mantil JC. C-11 Methionine PET for grading and prognostication in gliomas: a comparison study with F-18 FDG PET and contrast enhancement on MRI. J Nucl Med. 2012;53:1709–15.PubMedCrossRefGoogle Scholar
  4. 4.
    Tripathi M, Sharma R, Varshney R, et al. Comparison of F-18 FDG and C-11 methionine PET-CT for the evaluation of recurrent primary brain tumors. Clin Nucl Med. 2012;37:158–63.PubMedCrossRefGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Department of Nuclear Medicine and PETAll India Institute of Medical SciencesNew DelhiIndia

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