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Applications of PET-CT in Neurological Disorders: An Overview

  • Madhvi Tripathy
  • C. S. Bal
Chapter

Abstract

When positron emission tomography (PET) was introduced into medicine more than 30 years ago, the first organ of major interest was the brain. Presently, the applications of PET in neurology can be divided into the more commonly performed:

Keywords

Positron Emission Tomography Multiple System Atrophy Progressive Supranuclear Palsy Temporal Lobe Epilepsy Essential Tremor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

18F-MPPF

Methoxyphenyl-(N-2′-pyridinyl)-p-fluoro-benzamidoethyipiperazine that binds to the serotonin-1A receptor

AD

Alzheimer disease

AADC

Amino acid decarboxylase

CBS

Corticobasal syndrome

DAT

Dopamine transporter

DLBD

Diffuse Lewy body dementia

DOTATOC

DOTA-Tyr3-octreotide (a somatostatin analog)

DNA

Deoxyribonucleic acid

FDOPA

Fluorodopa min

F-18 FLT

32-Deoxy-32 fluorothymidine (marker for cellular proliferation)

FTD

Frontotemporal dementia

FMISO

Fluoromisonidazole (a hypoxia imaging agent)

F-18 FDDNP

[F-18]fluoroethyl) (methyl) amino] -2-naphthyl ethylidene malononitrile for studying binding patterns of amyloid plaque and tau tangles in Alzheimer disease

5-HT1A

A subtype of 5-hydroxytryptamine

GLUT

Glucose transporter

C-11 DTBZ

Dihydro tetrabenazine (used for the study of dopaminergic neuronal function)

C-11 CFT

Carbomethoxy-3-â-(4-fluorophenyl) tropane (for the study of distribution of dopamine transporters in the brain)

C-11 MP4A

C-11-labeled N-methyl-4-piperidyl-acetate for measurements of regional acetylcholine esterase activity in degenerative dementia

C-11 PMP

Methylpiperidin-4-yl propionate for the study of brain AChE activity in patients with AD and PD

C-11 CPK

1-[2-Chlorophenyl]-N-methyl-N-[1-methyl-propyl]-3-isoquinoline carboxamide used for quantification of activated microglia

C-11 PiB

Carbon-11-labeled Pittsburgh compound B, a marker of cortical fibrillar amyloid-beta load

C-11 SCH

A selective dopamine D1 antagonist

5-HT2A

5-Hydroxytryptamine (neurotransmitter serotonin (5-HT))

IPD

Idiopathic Parkinson’s disease

MCI

Mild cognitive impairment

MMSE

Mini-mental state examination

MSA

Multiple system atrophy

PCNSL

Primary CNS lymphoma

PSP

Progressive supranuclear palsy

SPM

Statistical parametric mapping

TLE

Temporal lobe epilepsy

VMAT

Vesicular monoamine transporter

VMAT

Volumetric modulated arc therapy

For Further Reading

  1. 1.
    Berti V, Pupi A, Mosconi L. PET-CT in diagnosis of dementia. Ann N Y Acad Sci. 2011;1228:81–92.PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Bohnen NI, Djang DS, Herholz K, et al. Effectiveness and safety of F-18 F-18 FDG PET in the evaluation of dementia: a review of recent literature. J Nucl Med. 2012;53:59–71.PubMedCrossRefGoogle Scholar
  3. 3.
    Carne RP, O’Brien TJ, Kilpatrick CJ, et al. MRI-negative PET –positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain. 2004;127:2276–85.PubMedCrossRefGoogle Scholar
  4. 4.
    Foster NL, Heidebrink JL, Clark CM, et al. F-18 FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimers disease. Brain. 2007;130:2616–35.PubMedCrossRefGoogle Scholar
  5. 5.
    Juhasz C, Chugani HT. Positron Emission tomography: glucose metabolism in extratemporal lobe epilepsy. In: Chugani HT, editor. Neuroimaging in epilepsy. New York: Oxford University Press; 2011. p. 141–55.Google Scholar
  6. 6.
    Silverman DHS, Small GW, Chang CY, et al. Positron emission tomography in evaluation of dementia. JAMA. 2001;286:2120–7.PubMedCrossRefGoogle Scholar
  7. 7.
    Uijl SG, Leijten FS, Arenda JB, et al. The added value of F-18 Fluorodeoxyglucose PET in screening for temporal lobe epilepsy surgery. Epilepsia. 2007;48(11):2121–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Department of Nuclear Medicine and PETAll India Institute of Medical SciencesNew DelhiIndia

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