Molecular Classification of Breast Cancers

  • Radhakrishna Selvi


Gene expression profiling studies have revealed the presence of multiple molecular subtypes or intrinsic subtypes of breast cancer and have also shown that the critical determinants of the biological behavior of breast cancers are hormone receptor–related genes, HER2-related genes, and proliferation-related genes. Clarity on the molecular classes of breast cancer will lead to a better understanding of the biology of breast cancer and may result in improved therapies directed toward particular molecular subsets.


Breast Cancer Recurrence Score High Histologic Grade Flat Epithelial Atypia Gene Expression Profile Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Reading

  1. 1.
    Allison KH. Molecular Pathology of Breast Cancer: What a Pathologist Needs to Know. Am J Clin Pathol. 2012;138:770–780.Google Scholar
  2. 2.
    Harris JR, Lippman ME, Osborne CK, Morrow M. Diseases of the breast. Philadelphia: Lippincott, Williams and Wilkins; 2009.Google Scholar
  3. 3.
    Kuerer H. Kuerer’s breast surgical oncology. New York: McGraw Hill Publishers; 2010.Google Scholar
  4. 4.
    Lips EH, Mulder L, de Ronde JJ et al. Breast cancer subtyping by immunohistochemistry and histological grade outperforms breast cancer intrinsic subtypes in predicting neoadjuvant chemotherapy response. Breast Cancer Res Treat. 2013;140:63–71.Google Scholar
  5. 5.
    Perou CM, Sorlie T, Eisen MB. Molecular portraits of human breast tumours. Nature. 2000;406:747–52.PubMedCrossRefGoogle Scholar
  6. 6.
    Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, Palacios J, Richardson AL, Schnitt SJ, Schmitt FC, Tan P-H, Tse GM, Badve S, Ellis IO. Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 2010;12:207.PubMedCentralPubMedGoogle Scholar
  7. 7.
    Viale G. The current state of breast cancer classification. Ann Oncol. 2012;23 Suppl 10:207–10.CrossRefGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  • Radhakrishna Selvi
    • 1
  1. 1.Chennai Breast CentreChennaiIndia

Personalised recommendations