Molecular Classification of Breast Cancers
Gene expression profiling studies have revealed the presence of multiple molecular subtypes or intrinsic subtypes of breast cancer and have also shown that the critical determinants of the biological behavior of breast cancers are hormone receptor–related genes, HER2-related genes, and proliferation-related genes. Clarity on the molecular classes of breast cancer will lead to a better understanding of the biology of breast cancer and may result in improved therapies directed toward particular molecular subsets.
KeywordsBreast Cancer Recurrence Score High Histologic Grade Flat Epithelial Atypia Gene Expression Profile Study
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