Overview of IHC in Breast Lesions
A detailed morphological analysis by careful scrutiny of hematoxylin and eosin-stained slides is sufficient to diagnose most breast lesions. However, many lesions defy classification by routine microscopy, by virtue of their complex morphology. The role of IHC in the diagnosis of mammary disease is growing, with the availability of increasing numbers of antibodies and technical advancements. The principal diagnostic applications of IHC include distinguishing usual epithelial hyperplasia from ADH/LG-DCIS and benign papillomas from papillary carcinoma, assessing stromal invasion, categorizing histologic subtypes, and identifying metastatic breast carcinoma. IHC also helps in confirming lymphovascular invasion.
KeywordsPapillary Carcinoma Myoepithelial Cell Adenoid Cystic Carcinoma Stromal Invasion Metaplastic Carcinoma
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