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Overview of IHC in Breast Lesions

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  • First Online:
Breast Diseases

  • 2018 Accesses

Abstract

A detailed morphological analysis by careful scrutiny of hematoxylin and eosin-stained slides is sufficient to diagnose most breast lesions. However, many lesions defy classification by routine microscopy, by virtue of their complex morphology. The role of IHC in the diagnosis of mammary disease is growing, with the availability of increasing numbers of antibodies and technical advancements. The principal diagnostic applications of IHC include distinguishing usual epithelial hyperplasia from ADH/LG-DCIS and benign papillomas from papillary carcinoma, assessing stromal invasion, categorizing histologic subtypes, and identifying metastatic breast carcinoma. IHC also helps in confirming lymphovascular invasion.

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Suggested Reading

  1. Bhargava R, Beriwal S, Dabbs DJ. Mammaglobin vs GCDFP-15, An Immunohistologic Validation Survey for Sensitivity and Specificity. Am J Clin Pathol. 2007;127:103–113.

    Google Scholar 

  2. Lerwill MF. Current Practical Applications of Diagnostic Immunohistochemistry in Breast Pathology. Am J Surg Pathol. 2004;28:8.

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  3. O’Malley FP, Pinder SE. Breast pathology. Edinburgh: Churchill Livingstone; 2006.

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  4. Walker RA, Hanby A, Pinder SE, Thomas J, Ellis IO. Current issues in diagnostic breast pathology. J Clin Pathol. 2012;65:771–785.

    Google Scholar 

  5. Yeh I-T, Mies C. Application of Immunohistochemistry to Breast Lesions. Arch Pathol Lab Med—Vol 132, March 2008 Breast Immunohistochemistry—Yeh & Mies 349.

    Google Scholar 

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Authors and Affiliations

  1. Chennai Breast Centre, Chennai, India

    Radhakrishna Selvi

Authors
  1. Radhakrishna Selvi
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© 2015 Springer India

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Selvi, R. (2015). Overview of IHC in Breast Lesions. In: Breast Diseases. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2077-0_27

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  • DOI: https://doi.org/10.1007/978-81-322-2077-0_27

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  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-2076-3

  • Online ISBN: 978-81-322-2077-0

  • eBook Packages: MedicineMedicine (R0)

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