Advertisement

Role of Progenitors in Pulmonary Fibrosis and Asthma

  • Ena Ray Banerjee
Chapter

Abstract

Tissue regeneration and repair are fundamental both to recovery of the lung from injury and to the pathology of many chronic lung diseases. There are two potential sources for the adult progenitor cells that participate in this reparative process: resident lung progenitors and bone marrow-derived circulating cells. Bone marrow-derived cells, in particular, have been shown to give rise to airway and alveolar epithelial cells as well as lung mesenchymal cells. Emerging data has linked specific chemokine ligand–receptor interactions to the recruitment of these cells to the lung and has implicated these cells in chronic lung disorders such as asthma and interstitial lung diseases.

Keywords

Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Side Population Obliterative Bronchiolitis Idiopathic Pulmonary Fibrosis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN (2001) Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 166:7556–7562PubMedCrossRefGoogle Scholar
  2. Alison MR, Poulsom R, Forbes S, Wright NA (2002) An introduction to stem cells. J Pathol 197:419–423PubMedCrossRefGoogle Scholar
  3. Andersson-Sjoland A, de Alba CG, Nihlberg K, Becerril C, Ramirez R, Pardo A et al (2008) Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 40:2129–2140PubMedCrossRefGoogle Scholar
  4. Andersson-Sjoland A, Nihlberg K, Eriksson K et al (2011) Fibrocytes and the tissue niche in lung repair. Respir Res 12:76PubMedCrossRefPubMedCentralGoogle Scholar
  5. Banerjee ER, Henderson WR Jr (2012a) Characterization of lung stem cell niches in a mouse model of bleomycin – induced fibrosis. Stem Cell Res Ther 3:21PubMedCrossRefPubMedCentralGoogle Scholar
  6. Banerjee ER, Henderson WR Jr (2012b) Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model. Clin Mol Allergy 2012:10.2Google Scholar
  7. Banerjee ER, Henderson WR Jr (2013) RESEARCH open Access role of T cells in a gp91 Phox knockout murine model of acute allergic asthmaGoogle Scholar
  8. Bensadoun ES, Burke AK, Hogg JC, Roberts CR (1996) Proteoglycan deposition in pulmonary fibrosis. Am J Respir Crit Care Med 154:1819–1828PubMedCrossRefGoogle Scholar
  9. Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME et al (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10:858–864PubMedCrossRefGoogle Scholar
  10. Christopher MJ, Liu F, Hilton MJ, Long F, Link DC (2009) Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood 114:1331–1339PubMedCrossRefPubMedCentralGoogle Scholar
  11. Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST (2003) Airway remodeling in asthma: new insights. J Allergy Clin Immunol 111:215–225PubMedCrossRefGoogle Scholar
  12. Gardner LB, Corn PG (2008) Hypoxic regulation of mRNA expression. Cell Cycle 7:1916–1924PubMedCrossRefGoogle Scholar
  13. Giangreco A, Reynolds SD, Stripp BR (2002) Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol 161:173–182PubMedCrossRefPubMedCentralGoogle Scholar
  14. Giangreco A, Shen H, Reynolds SD, Stripp BR (2004) Molecular phenotype of airway side population cells. Am J Physiol Lung Cell Mol Physiol 286:L624–L630PubMedCrossRefGoogle Scholar
  15. Gomperts BN, Belperio JA, Rao PN, Randell SH, Fishbein MC, Burdick MD, Strieter RM (2006) Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol 176:1916–1927PubMedCrossRefGoogle Scholar
  16. Hashimoto M, Tanaka H, Abe S (2005) Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. Chest 127:965–972PubMedCrossRefGoogle Scholar
  17. Hocking DC (2002) Fibronectin matrix deposition and cell contractility: implications for airway remodeling in asthma. Chest 122:275S–278SPubMedCrossRefGoogle Scholar
  18. Huang J, Olivenstein R, Taha R, Hamid Q, Ludwig M (1999) Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am J Respir Crit Care Med 160:725–729PubMedCrossRefGoogle Scholar
  19. Keane MP, Arenberg DA, Lynch JP, Whyte RI, Iannettoni MD, Burdick MD et al (1997) The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 159:1437–1443PubMedGoogle Scholar
  20. King TE, Schwarz MI, Brown K, Tooze JA, Colby TV, Waldron JA Jr et al (2001) Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med 164:1025–1032PubMedCrossRefGoogle Scholar
  21. Mehrad B, Keane MP, Gomperts BN, Strieter RM (2007) Circulating progenitor cells in chronic lung disease. Respir Med 1(1):157–165Google Scholar
  22. Mehrad B, Burdick MD, Strieter RM (2009) Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int J Biochem Cell Biol 41:1708–1718PubMedCrossRefPubMedCentralGoogle Scholar
  23. Moeller A, Gilpin SE, Ask K, Cox G, Cook D, Gauldie J et al (2009) Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 179:588–594PubMedCrossRefGoogle Scholar
  24. Nicod LP (2006) Mechanisms of airway obliteration after lung transplantation. Proc Am Thorac Soc 3:444–449PubMedCrossRefGoogle Scholar
  25. Nihlberg K, Larsen K, Hultgardh-Nilsson A, Malmstrom A, Bjermer L, Westergren-Thorsson G (2006) Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane? Respir Res 7:50PubMedCrossRefPubMedCentralGoogle Scholar
  26. Nihlberg K, Andersson-Sjoland A, Tufvesson E, Erjefalt JS, Bjermer L, Westergren-Thorsson G (2010) Altered matrix production in the distal airways of individuals with asthma. Thorax 65:670–676PubMedCrossRefGoogle Scholar
  27. Pardo A, Selman M (2002) Idiopathic pulmonary fibrosis: new insights in its pathogenesis. Int J Biochem Cell Biol 34:1534–1538PubMedCrossRefGoogle Scholar
  28. Pardo A, Selman M, Kaminski N (2008) Approaching the degradome in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 40:1141–1155PubMedCrossRefGoogle Scholar
  29. Payne DN, Rogers AV, Adelroth E, Bandi V, Guntupalli KK, Bush A et al (2003) Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 167:78–82PubMedCrossRefGoogle Scholar
  30. Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA et al (2005) Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3 kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem 280:22473–22481PubMedCrossRefGoogle Scholar
  31. Sage EK, Loebinger MR, Polak J, Janes SM (2008) The role of bone marrow – derived stem cells in lung regeneration and repair (30 September 2008). In: StemBook (ed) The Stem Cell Research Community, StemBook. doi: 10.3824/stembook.1.20.1
  32. Salvato G (2001) Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 56:902–906PubMedCrossRefPubMedCentralGoogle Scholar
  33. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S (2003) Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 171:380–389PubMedCrossRefGoogle Scholar
  34. Summer R, Kotton DN, Sun X, Fitzsimmons K, Fine A (2004) Translational physiology: origin and phenotype of lung side population cells. Am J Physiol Lung Cell Mol Physiol 287:L477–L483PubMedCrossRefGoogle Scholar
  35. Wang CH, Huang CD, Lin HC, Lee KY, Lin SM, Liu CY et al (2008) Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care Med 178:583–591PubMedCrossRefGoogle Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  • Ena Ray Banerjee
    • 1
  1. 1.Department of ZoologyUniversity of CalcuttaKolkataIndia

Personalised recommendations