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Hydrogen Peroxide Sensing and Signaling

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Free Radicals in Human Health and Disease

Abstract

H2O2 has been found to act as a signaling molecule and secondary messenger in many signal transduction pathways like in insulin signaling, cell proliferation, and apoptosis. There are biological sensors which sense the presence of H2O2 and trigger downstream signaling events which in turn activate complex disease pathways. A balance in the H2O2 levels is achieved by its compartmentalization in different cellular compartments and level is maintained by the antioxidant enzymes like catalase, glutathione peroxidase, and thioredoxin peroxidase. In this chapter we describe the way H2O2 is sensed in the biological system and further explain the downstream signaling events. We also explain the role of H2O2 signaling during specific biological events and disease conditions.

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    Authors and Affiliations

    1. Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307, Uttar Pradesh, India

      Vibha Rani, Shivangi Mishra & Tanuja Yadav

    2. School of Life Sciences, Central University of Gujarat, Sector 30, Gandhinagar, Gujarat, 382030, India

      Umesh Chand Singh Yadav

    3. Universitatsklinkum, Medical Faculty at Otto Von Guericke University, Magdeburg, Germany

      Shrey Kohli

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    1. Vibha Rani
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    Correspondence to Vibha Rani .

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    Editors and Affiliations

    1. Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India

      Vibha Rani

    2. School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India

      Umesh Chand Singh Yadav

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    Rani, V., Mishra, S., Yadav, T., Yadav, U.C.S., Kohli, S. (2015). Hydrogen Peroxide Sensing and Signaling. In: Rani, V., Yadav, U. (eds) Free Radicals in Human Health and Disease. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2035-0_8

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