Oxidative Stress and Carcinogenesis

  • Mohinder Bansal
  • Naveen Kaushal


Cancer is a complex disease where uncontrolled proliferation of cells takes place. In addition to the external environment, cell’s internal environment is a critical factor in carcinogenesis. ROS mediated oxidative stress sets the tone for the cancer development. Role of free radicals induced oxidative stress by modulating the molecular pathways of cell cycle regulation contribute to the initiation, progression and metastasis of various cancers. ROS mediated changes in the p53 dependent pathway of apoptosis is one of the most common and widely studied pathway. Here we have discussed the contribution of oxidative stress in the molecular pathways which are central to various stages of cancer development and progression.


Cellular Senescence MnSOD Activity Malignant Epithelial Cell EGFR Activation CDC25 Phosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2014

Authors and Affiliations

  • Mohinder Bansal
    • 1
  • Naveen Kaushal
    • 1
  1. 1.Department of BiophysicsPanjab UniversityChandigarhIndia

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