Pharmacotherapy of CVI

  • Subramoniam Vaidyanathan


Pharmacotherapy of chronic venous insufficiency (CVI) and varicose veins is an area which cannot claim significant progress. Several drugs are used to control the symptoms of chronic venous disorders and promote healing of venous ulcers. None of them are effective in altering the course of the disease. The wonder drug in this arena would be one that can completely reverse the underlying molecular pathology of this disease.


Ulcer Healing Varicose Vein Ginkgo Extract Venous Ulcer Chronic Venous Insufficiency 
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  1. 1.
    Perrin M, Ramelett AA. Pharmacological treatment of chronic venous disease: rationale, results & unanswered questions. Eur J Vasc Endovasc Surg. 2011;41:117–25.PubMedCrossRefGoogle Scholar
  2. 2.
    Coleridge Smith PD. Drug treatment of varicose veins, venous edema and ulcers. In: Gloviczki P, editor. Handbook of venous disorders: guidelines of the American Venous Forum. 3rd ed. London: Hodder Arnold; 2009. p. 359–65.Google Scholar
  3. 3.
    Bergan JJ, Pascarella L, Schmid-Schonbein GW. Pathogenesis of primary chronic venous disease: insights from animal models of venous hypertension. J Vasc Surg. 2008;47:183–92.PubMedCrossRefGoogle Scholar
  4. 4.
    Bergan JJ. Chronic venous insufficiency and the therapeutic effects of Daflon 500 mg. Angiology. 2005;55(Suppl I):S21–4.CrossRefGoogle Scholar
  5. 5.
    Valencia IC, Flabella A, Kirsner RS, Eaglestein WH. Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol. 2001;44:401–23.PubMedCrossRefGoogle Scholar
  6. 6.
    Ciapponi A, Laffaire E, Roque M. Calcium dobesilate for chronic venous insufficiency; a systematic review. Angiology. 2004;55(2):147–54.PubMedCrossRefGoogle Scholar
  7. 7.
    Rabe E, Jaeqer KA, Bulitta M, Pannier F. Calcium dobesilate in patients suffering from chronic venous insufficiency; a double blind placebo controlled clinical trial. Phlebology. 2011;26(4):162–83.PubMedCrossRefGoogle Scholar
  8. 8.
    Royal College of Nursing. Clinical practice guidelines: the nursing management of patients with venous leg ulcers. London: Royal College of Nursing; 2006. Publication Code: 003020. ISBN 1-904114-22-9.Google Scholar
  9. 9.
    Mortimer PS, Burnand KG, Neumann HAM. Diseases of veins and arteries: leg ulcers. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s text book of dermatology. 8th ed. Oxford: Wileyblackwell; 2010. p. 2270.Google Scholar
  10. 10.
    Belcaro G, Marelli C. Treatment of venous lipodermatosclerosis and ulceration in venous hypertension by elastic compression and fibrinolytic enhancement with defibrotide. Phlebology. 1989;4(2):91–106.Google Scholar
  11. 11.
    Yosipovitch G, Mengesha Y, Facliaru D, David M. Topical capsaicin for treatment of acute lipodermatosclerosis and lobular panniculitis. J Dermatol Treat. 2005;16:178–80.CrossRefGoogle Scholar
  12. 12.
    Raffetto JD, Khalil RA. Matrix metalloproteinases in venous tissue remodelling and varicose vein formation. Curr Vasc Pharmacol. 2008;6(3):158–72.PubMedCrossRefGoogle Scholar
  13. 13.
    Kucukguven A, Khalil RA. Matrix metalloproteinases as potential targets in venous dilatation associated with varicose veins. Curr Drug Targets. 2013;14(3):287–324.PubMedPubMedCentralGoogle Scholar
  14. 14.
    Henke PK, Comerota AJ. An update on etiology, prevention and therapy of postthrombotic syndrome. J Vasc Surg. 2011;53:500–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Glynn RJ, Danielson E, Fonseca FAH, Genest J, Gotto Jr AM, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, Mac Fadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Ridker PM. A randomised trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009;360:1851–61.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.General SurgeryAmrita Institute of Medical Sciences, Amrita LaneKochiIndia

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