Quorum Sensing in Escherichia coli: Interkingdom, Inter- and Intraspecies Dialogues, and a Suicide-Inducing Peptide
An emerging theme in microbiology is the ability of bacteria to communicate with one another via quorum-sensing signal molecules (Bassler and Losick, Cell 125:237–246, 2006; Camilli and Bassler, Science 311:1113–1116, 2006; Fuqua et al., Annu Rev Microbiol 50:727–751, 1996; Waters and Bassler, Annu Rev Cell Dev Biol 21:319–346, 2005). Quorum sensing provides a mechanism for bacteria to monitor one another’s presence and to modulate gene expression in response to population density. In the simplest scenario, accumulation of a threshold autoinducer concentration, which is correlated with increasing population density, initiates a signal transduction cascade that culminates in a population-wide alteration in gene expression. Our text brought here is highlighting the recent development in the study of quorum-sensing behaviors in E. coli. This bacterium intriguingly integrates self-produced quorum-sensing signals as well as signals produced by epithelial cells and neighbor gut bacteria.
KeywordsAcid Resistance luxS Mutant LuxR Homolog LuxI Homolog Indole Concentration
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