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Quorum Sensing in Competence and Sporulation

  • Navneet Rai
  • Rewa Rai
  • K. V. Venkatesh
Chapter

Abstract

In several Gram-positive bacteria, competence and sporulation are few of several physiological processes controlled by quorum sensing (QS). Competence is a phenomenon wherein a bacterium acquires extracellular DNA for its maintenance. Only a fraction of cells (10–20 %), in a population, develop competence, at a particular window of growth phase, and in response upregulate expression of genes involved in the uptake and processing of extracellular DNA. Sporulation, second QS-controlled phenotype, occurs under extreme stress and nutritional scarcity. Prolonged nutrient deprivation compels the cell to enter the process of sporulation, the outcome of which is the production of a metabolically dormant endospore that resumes growth once the conditions become favorable again. Spore formation is a complex and tightly regulated phenomenon, where several hundred genes are directly and indirectly involved. Regulation of competence and sporulation is a complex and temporally regulated process. In present chapter, we will discuss QS driven regulation of competence and sporulation in different Gram-positive bacteria.

Keywords

Quorum Sense Competence Development Competence Gene Quorum Sense Molecule Response Regulator Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Bacon Schneider K, Palmer TM, Grossman AD (2002) Characterization of comQ and comX, two genes required for production of ComX pheromone in Bacillus subtilis. J Bacteriol 184(2):410–419PubMedCrossRefGoogle Scholar
  2. Hamoen LW, Venema G, Kuipers OP (2003) Controlling competence in Bacillus subtilis: shared use of regulators. Microbiology 149(Pt 1):9–17PubMedCrossRefGoogle Scholar
  3. Johnsborg O, Havarstein LS (2009) Regulation of natural genetic transformation and acquisition of transforming DNA in Streptococcus pneumoniae. FEMS Microbiol Rev 33(3):627–642PubMedCrossRefGoogle Scholar
  4. Lazazzera BA, Solomon JM, Grossman AD (1997) An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis. Cell 89(6):917–925PubMedCrossRefGoogle Scholar
  5. Lopez D, Kolter R (2010) Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis. FEMS Microbiol Rev 34(2):134–149PubMedCrossRefGoogle Scholar
  6. Luo P, Li H, Morrison DA (2004) Identification of ComW as a new component in the regulation of genetic transformation in Streptococcus pneumoniae. Mol Microbiol 54(1):172–183PubMedCrossRefGoogle Scholar
  7. Maamar H, Dubnau D (2005) Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop. Mol Microbiol 56(3):615–624PubMedCrossRefGoogle Scholar
  8. Mashburn-Warren L, Morrison DA, Federle MJ (2010) A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. Mol Microbiol 78(3):589–606PubMedCrossRefPubMedCentralGoogle Scholar
  9. Narula J, Devi SN, Fujita M, Igoshin OA (2012) Ultrasensitivity of the Bacillus subtilis sporulation decision. Proc Natl Acad Sci U S A 109(50):E3513–E3522PubMedCrossRefPubMedCentralGoogle Scholar
  10. Okada M, Sato I, Cho SJ, Iwata H, Nishio T, Dubnau D, Sakagami Y (2005) Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX. Nat Chem Biol 1(1):23–24PubMedCrossRefGoogle Scholar
  11. Peterson S, Cline RT, Tettelin H, Sharov V, Morrison DA (2000) Gene expression analysis of the Streptococcus pneumoniae competence regulons by use of DNA microarrays. J Bacteriol 182(21):6192–6202PubMedCrossRefPubMedCentralGoogle Scholar
  12. Waters CM, Bassler BL (2005) Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 21:319–346PubMedCrossRefGoogle Scholar
  13. Weng L, Piotrowski A, Morrison DA (2013) Exit from competence for genetic transformation in Streptococcus pneumoniae is regulated at multiple levels. PLoS One 8(5):e64197PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Genome CenterUniversity of California DavisDavisUSA
  2. 2.Department of ChemistryIndian Institute of Technology DelhiHauz Khas, New DelhiIndia
  3. 3.Department of Chemical EngineeringIndian Institute of Technology BombayPowai, MumbaiIndia

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