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The Battle: Quorum-Sensing Inhibitors Versus Evolution of Bacterial Resistance

  • Vipin C. Kalia
  • Prasun Kumar
Chapter

Abstract

During the last few centuries, human beings had high mortality and morbidity rate. At times, a large population was completely wiped away. Although these were ‘diagnosed’ to be caused by bacterial infections, however, in the absence of any effective treatment, people helplessly watched the patient dying. The discovery of antibiotics in the twentieth century brought a revolution in human health. Microbial infections in human beings could be treated through the regular and at times indiscriminate administration of antibiotics (Davies et al. 2006). Today, bacteria have developed resistance to quite a few antibiotics (Davies and Davies 2010). Pharmaceutical companies are hesitant to invest in searching novel antibiotics. The scenario is further exacerbated by infections caused by biofilm-forming bacteria. This structure provides additional resistance to antibiotics. One needs up to 1,000 higher doses of antibiotics for dispersing the biofilm (Nadell et al. 2008). Biofilms are formed through the phenomenon known as quorum sensing (QS). QS operates through a wide range of signal molecules, the most widely reported being oligopeptides and acylhomoserine lactones (AHLs) (McDougald et al. 2007). At low cell densities bacteria continue to multiply silently and are able to evade the host’s defence (Hentzer et al. 2003). Hence, while the infection is spreading, the ‘patient’ does not realize their presence. At high cell densities, bacteria activate their arsenal of virulence, and the disease spreads so rapidly that the patient is taken by surprise. At this stage, antibiotic therapy does not function effectively. It was realized that disrupting the QS system may help to let bacteria grow without getting into virulence mode. Quite a bit of effort has gone into searching quorum-sensing inhibitors (QSIs).

Keywords

Efflux Pump Quorum Sense Quorum Sense System Acylhomoserine Lactone Quorum Sense Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors wish to thank the Director of CSIR-Institute of Genomics and Integrative Biology (IGIB), CSIR-INDEPTH (BSC0111), and the Government of India for providing the necessary funds and facilities. PK is thankful to CSIR for granting Senior Research Fellowship.

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Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Microbial Biotechnology and GenomicsCSIR-Institute of Genomics and Integrative BiologyDelhiIndia

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