Potential Applications of Quorum Sensing Inhibitors in Diverse Fields



All organisms are susceptible to attack by other organisms, and it may even spell death for the recipient. However, each organism is also bestowed with an inherent ability to protect itself by developing self-defence mechanisms. Human beings have a strong immune system but are quite susceptible to infections by fungi, bacteria and viruses. Microbial infections have been a constant worry for health departments (Kalia 2013, 2014). The economy of a nation is dramatically affected by the health of its residents. The discovery of antibiotics was a great boon to mankind. However, microbes have been developing resistance against antibiotics. So much so that during the last seven to eight decades, there has been a need to find new antibiotics. Now the scenario is quite depressing as almost all antibiotics are proving ineffective. The evolution of multidrug resistance among pathogenic microbes has taken a new dimension (Davies and Davies 2010). Bacteria expressing their virulent behaviour through the phenomenon of quorum sensing (QS) develop a biofilm. Bacteria inside the biofilm are up to 1000 times more resistant to antibiotics compared to their planktonic counterparts (Kalia et al. 2014a, b). Research efforts during the last four decades have brought hope by providing alternatives and supplements to antibiotics. Quorum sensing inhibitors (QSIs) are seen as novel drugs especially against infectious bacteria. Although, the search for QSIs was intended for helping human beings to fight against diseases, the applications can be extended to other fields as well: agriculture, aquaculture, water treatment, fisheries, etc. A few examples of applications of QSIs have been described below (Table 1).


Quorum Sense Kojic Acid Quorum Sense System Quorum Sense Signal Quorum Quenching 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Acyl homoserine lactone


Homoserine lactone




3-oxo-N-dodecanoyl- HSL


Quorum quenching


Quorum sensing


Quorum sensing inhibitors


Quorum sensing systems



The authors wish to thank the director of CSIR-Institute of Genomics and Integrative Biology (IGIB), CSIR-INDEPTH (BSC0111), Government of India, for providing the necessary funds and facilities. PK is thankful to CSIR for granting Senior Research Fellowship.


  1. Agarwala M, Choudhury B, Yadav RNS (2014) Comparative study of antibiofilm activity of copper oxide and iron oxide nanoparticles against multidrug resistant biofilm forming uropathogens. Indian J Microbiol. doi: 10.1007/s12088-014-0462-z PubMedGoogle Scholar
  2. Anderson JC, Clarke EJ, Arkin AP, Voigt CA (2006) Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol 355:619–627. doi: 10.1016/j.jmb.2005.10.076 PubMedGoogle Scholar
  3. Annapoorani A, Jabbar AKKA, Musthafa SKS, Pandian SK, Ravi AV (2012) Inhibition of quorum sensing mediated virulence factors production in urinary pathogen Serratia marcescens PS1 by marine sponges. Indian J Microbiol 52:160–166. doi: 10.1007/s12088-012-0272-0 PubMedPubMedCentralGoogle Scholar
  4. Arciola CR, Montanaro L, Costerton JW (2011) New trends in diagnosis and control strategies for implant infections. Int J Artif Organs 34:727–736. doi: 10.5301/IJAO.2011.8784 PubMedGoogle Scholar
  5. Avella MA, Gioacchini G, Decamp O, Makridis P, Bracciatelli C, Carnevali O (2010) Application of multi-species of Bacillus in sea bream larviculture. Aquaculture305:12. doi: 10.1016/j.aquaculture.2010.03.029
  6. Azizi S, Valipour A, Sithebe T (2013) Evaluation of different wastewater treatment processes and development of a modified attached growth bioreactor as a decentralized approach for small communities. The Scientific World Journal 2013. Article ID 156870, 8 pgs. doi: 10.1155/2013/156870
  7. Bakkiyaraj D, Sivasankar C, Pandian SK (2013) Anti-pathogenic potential of coral associated bacteria isolated from Gulf of Mannar against Pseudomonas aeruginosa. Indian J Microbiol 53:111–113. doi: 10.1007/s12088-012-0342-3 PubMedPubMedCentralGoogle Scholar
  8. Basu S, Mehreja R, Thiberge S, Chen MT, Weiss R (2004) Spatiotemporal control of gene expression with pulse-generating networks. Proc Natl Acad Sci U S A 101:6355–6360. doi: 10.1073/pnas.0307571101 PubMedPubMedCentralGoogle Scholar
  9. Bjarnsholt T, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen H-P, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M (2005) Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology 151:3873–3880. doi: 10.1099/mic.0.27955-0 PubMedGoogle Scholar
  10. Boles BR, Horswill AR (2011) Staphylococcal biofilm disassembly. Trends Microbiol 19:449–455. doi: 10.1016/j.tim.2011.06.004 PubMedPubMedCentralGoogle Scholar
  11. Brenner K, Karig DK, Weiss R, Arnold FH (2007) Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium. Proc Natl Acad Sci USA 104:17300–17304. doi: 10.1073/pnas.0704256104 PubMedPubMedCentralGoogle Scholar
  12. Cam DTV, Nhan DT, Ceuppens S, Hao NV, Dierckens K, Wille M, Sorgeloos P, Bossier P (2009) Effect of N-acyl homoserine lactone-degrading enrichment cultures on Macrobrachium rosenbergiii larviculture. Aquaculture 294:5–13Google Scholar
  13. Carlier A, Uroz S, Smadja B, Fray R, Latour X, Dessaux Y, Faure D (2003) The Ti plasmid of Agrobacterium tumefaciens harbors an attM-paralogous gene, aiiB, also encoding N-acyl homoserine lactonase activity. Appl Environ Microbiol 69:4989–4993. doi: 10.1128/AEM.69.8.4989-4993.2003 PubMedPubMedCentralGoogle Scholar
  14. Chan K-G, Yin W-F, Sam C-K, Koh C-L (2010) A novel medium for the isolation of N-acylhomoserine lactone-degrading bacteria. J Ind Microbiol Biotechnol 36:247–251. doi: 10.1007/s10295-008-0491-x Google Scholar
  15. Chen R, Zhou Z, Cao Y, Yao B (2010) High yield expression of an AHL-lactonase from Bacillus sp. B546 in Pichia pastoris and its application to reduce Aeromonas hydrophila mortality in aquaculture. Microb Cell Fact 9:39PubMedPubMedCentralGoogle Scholar
  16. Choudhary S, Schmidt-Dannert C (2010) Applications of quorum sensing in biotechnology. Appl Microbiol Biotechnol 86:1267–1279. doi: 10.1007/s00253-010-2521-7 PubMedGoogle Scholar
  17. Chu W, Zere TR, Weber MM, Wood TK, Whiteley M, Hidalgo-Romano B, Valenzuela EJ, McLean RJ (2012) Indole production promotes Escherichia coli mixed-culture growth with Pseudomonas aeruginosa by inhibiting quorum signaling. Appl Environ Microbiol 78:411–419. doi: 10.1128/AEM.06396-11 PubMedPubMedCentralGoogle Scholar
  18. Chu W, Liu Y, Jiang Y, Zhu W, Zhuang X (2013) Production of N-acyl homoserine lactones and virulence factors of waterborne Aeromonas hydrophila. Indian J Microbiol 53:264–268. doi: 10.1007/s12088-013-0381-4 PubMedPubMedCentralGoogle Scholar
  19. Cirou A, Mondy S, An S, Charrier A, Sarrazin A, Thoison O, DuBow M, Faure D (2012) Efficient biostimulation of native and introduced quorum-quenching Rhodococcus erythropolis populations is revealed by a combination of analytical chemistry, microbiology, and pyrosequencing. Appl Environ Microbiol 78:481–492. doi: 10.1128/AEM.06159-11 PubMedPubMedCentralGoogle Scholar
  20. Clarke-Sturman AJ, Den Ottelander D, Sturla PL (1989) Succinoglycan: a new biopolymer for the oil field. Oil-Field Chem, Prepr; (United States), 33 396:157–168. doi: 10.1021/bk-1989-0396.ch008
  21. Cooley H, Gleick PH, Wolff G (2006) Desalination, with a grain of salt – A california perspective. Pacific Institute for Studies in Development, Environment, and Security. Oakland, CAGoogle Scholar
  22. Craigen B, Dashiff A, Kadouri DE (2011) The use of commercially available alpha-amylase compounds to inhibit and remove Staphylococcus aureus biofilms. Open Microbiol J 5:21–31. doi: 10.2174/1874285801105010021 PubMedPubMedCentralGoogle Scholar
  23. Danino T, Mondragón-Palomino O, Tsimring L, Hasty J (2010) A synchronized quorum of genetic clocks. Nature 463:326–330. doi: 10.1038/nature08753 PubMedPubMedCentralGoogle Scholar
  24. Darouiche RO, Mansouri MD, Gawande PV, Madhyastha S (2009) Antimicrobial and antibiofilm efficacy of triclosan and DispersinB® combination. J Antimicrob Chemother 64:88–93. doi: 10.1093/jac/dkp158 PubMedGoogle Scholar
  25. Davies J, Davies D (2010) Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev 74:417–433. doi: 10.1128/MMBR.00016-10 PubMedPubMedCentralGoogle Scholar
  26. de Nys R, Givskov M, Kumar N, Kjelleberg S, Steinberg PD (2006) Furanones. Prog Mol Subcell Biol 42:55–86. doi: 10.1007/3-540-30016-3_2 PubMedGoogle Scholar
  27. Defoirdt T, Boon N, Bossier P, Verstraete W (2004) Disruption of bacterial quorum sensing: an unexplored strategy to fight infections in aquaculture. Aquaculture 240:69–88Google Scholar
  28. Defoirdt T, Crab R, Wood TK, Sorgeloos P, Verstraete W, Boossier P (2006) Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii and Vibrio parahaemolyticus isolates. Appl Environ Microbiol 72:6419–6423. doi: 10.1128/AEM.00753-06 PubMedPubMedCentralGoogle Scholar
  29. Defoirdt T, Sorgeloos P, Bossier P (2011) Alternatives to antibiotics for the control of bacterial disease in aquaculture. Curr Opin Microbiol 14:251–258. doi: 10.1016/j.mib.2011.03.004 PubMedGoogle Scholar
  30. Deng Y, Lim A, Lee J, Chen S, An S, Dong YH, Zhang LH (2014) Diffusible signal factor (DSF) quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens. BMC Microbiol 14:51. doi: 10.1186/1471-2180-14-51 PubMedPubMedCentralGoogle Scholar
  31. Dobretsov S, Teplitski M, Bayer M, Gunasekra S, Proksch P, Paul VJ (2011) Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Biofouling 27:893–905. doi: 10.1080/08927014.2011.609616 PubMedPubMedCentralGoogle Scholar
  32. Dong YH, Xu JL, Li XZ, Zhang LH (2000) AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora. Proc Natl Acad Sci U S A 97:3526–3531. doi: 10.1073/pnas.97.7.3526 PubMedPubMedCentralGoogle Scholar
  33. Dong YH, Wang LH, Xu JL, Zhang HB, Zhang XF, Zhang LH (2001) Quenching quorum-sensing dependent bacterial infection by an N-acyl homoserine lactonase. Nature 411:813–817PubMedGoogle Scholar
  34. Donlan RM (2002) Biofilms: microbial life on surfaces. Emerg Infect Dis 8:881–890PubMedPubMedCentralGoogle Scholar
  35. Dulla GFJ, Lindow SE (2009) Acyl-homoserine lactone-mediated cross talk among epiphytic bacteria modulates behaviour of Pseudomonas on leaves. ISME J 3:825–834. doi: 10.1038/ismej.2009.30 PubMedGoogle Scholar
  36. Ettinger-Epstein P, Tapiolas DM, Motti CA, Wright AD, Battershill CN, de Nys R (2008) Production of manoalide and its analogues by the sponge Luffariella variabilis is hardwired. Marine Biotechnol 10:64–74. doi: 10.1007/s10126-007-9037-x Google Scholar
  37. Girennavar B, Cepeda ML, Soni KA, Vikram A, Jesudhasan P, Jayaprakasha GK, Pillai SD, Patil BS (2008) Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria. Int J Food Microbiol 125:204–208. doi: 10.1016/j.ijfoodmicro.2008.03.028 PubMedGoogle Scholar
  38. Grice EA, Segre JA (2011) The skin microbe. Nat Rev Microbiol 9:244–253. doi: 10.1038/nrmicro2537 PubMedPubMedCentralGoogle Scholar
  39. Gui Z, Wang H, Ding T, Zhu W, Zhuang X, Chu W (2014) Azithromycin reduces the production of α-hemolysin and biofilm formation in Staphylococcus aureus. Indian J Microbiol 54:114–117. doi: 10.1007/s12088-013-0438-4 PubMedGoogle Scholar
  40. Hentzer M, Riedel K, Rasmussen TB, Heydorn A, Andersen JB, Parsek MR, Rice SA, Eberl L, Molin S, Høiby N, Kjelleberg S, Givskov M (2002) Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 148:87–102PubMedGoogle Scholar
  41. Hentzer M, Wu H, Andersen JB, Riedel K, Rasmussen TB, Bagge N, Kumar N, Schembri MA, Song Z, Kristoffersen P, Manefield M, Costerton JW, Molin S, Eberl L, Steinberg P, Kjelleberg S, Høiby N, Givskov M (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J 22:3803–3815. doi: 10.1093/emboj/cdg366 PubMedPubMedCentralGoogle Scholar
  42. Hong KW, Koh CL, Sam CK, Yin WF, Chan KG (2012a) Quorum quenching revisited – from signal decays to signalling confusion. Sensors 12:4661–4696. doi: 10.3390/s120404661 PubMedPubMedCentralGoogle Scholar
  43. Hong SH, Hegde M, Kim J, Wang J, Jayaram A, Wood TK (2012b) Synthetic quorum-sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device. Nat Commun 3:613. doi: 10.1038/ncomms1616 PubMedPubMedCentralGoogle Scholar
  44. Hooshangi S, Bentley WE (2008) From unicellular properties to multicellular behavior: bacteria quorum sensing circuitry and applications. Curr Opin Biotechnol 19:550–555. doi: 10.1016/j.copbio.2008.10.007 PubMedGoogle Scholar
  45. Houdt R, Aertsen A, Moons P, Vanoirbeek K, Michiels CW (2006) N‐acyl‐l‐homoserine lactone signal interception by Escherichia coli. FEMS Microbiol Lett 256:83–89. doi: 10.1111/j.1574-6968.2006.00103.x PubMedGoogle Scholar
  46. Huang CJ, Lin H, Yang X (2012) Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements. J Ind Microbiol Biotechnol 39:383–399. doi: 10.1007/s10295-011-1082-9 PubMedGoogle Scholar
  47. Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PØ, Moser C, Nielsen KF, Eberl L, Larsen TO, Tanner D, Høiby N, Bjarnsholt T, Givskov M (2012) Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob Agents Chemother 56:2314–2325. doi: 10.1128/AAC.05919-11 PubMedPubMedCentralGoogle Scholar
  48. Jamuna Bai A, Rai VR (2011) Bacterial quorum sensing and food industry. Compr Rev Food Sci Food Saf 10:183–194. doi: 10.1111/j.1541-4337.2011.00150.x Google Scholar
  49. Jayaraman A, Wood TK (2008) Bacterial quorum sensing: signals, circuits, and implications for biofilms and disease. Annu Rev Biomed Eng 10:145–167. doi: 10.1146/annurev.bioeng.10.061807.160536 PubMedGoogle Scholar
  50. Kalia VC (2013) Quorum sensing inhibitors: an overview. Biotechnol Adv 31:224–245. doi: 10.1016/j.biotechadv.2012.10.004 PubMedGoogle Scholar
  51. Kalia VC (2014) Microbes, antimicrobials and resistance: the battle goes on. Indian J Microbiol 54:1–2. doi: 10.1007/s12088-013-0443-7 PubMedGoogle Scholar
  52. Kalia VC, Kumar P, Pandian SK, Sharma P (2014a) Biofouling control by quorum quenching. In: Kim SK (ed) Handbook of marine biotechnology. SpringerGoogle Scholar
  53. Kalia VC, Wood TK, Kumar P (2014b) Evolution of resistance to quorum-sensing inhibitors. Microb Ecol 68(1):13–23. doi: 10.1007/s00248-013-0316-y PubMedGoogle Scholar
  54. Kim J-H, Choi D-C, Yeon K-M, Kim S-R, Lee C-H (2011) Enzyme-immobilized nanofiltration membrane to mitigate biofouling based on quorum quenching. Environ Sci Technol 45:1601–1607. doi: 10.1021/es103483j PubMedGoogle Scholar
  55. Kim SR, Oh HS, Jo SJ, Yeon KM, Lee CH, Lim DJ, Lee CH, Lee JK (2013) Biofouling control with bead-entrapped quorum quenching bacteria in membrane bioreactors: physical and biological effects. Environ Sci Technol 47:836–842. doi: 10.1021/es303995s PubMedGoogle Scholar
  56. Kumar P, Patel SKS, Lee JK, Kalia VC (2013) Extending the limits of Bacillus for novel biotechnological applications. Biotechnol Adv 31:1543–1561. doi: 10.1016/j.biotechadv.2013.08.007 PubMedGoogle Scholar
  57. Lane AL, Nyadong L, Galhena AS, Shearer TL, Stout EP, Parry RM, Kwasnika M, Wang MD, Hay ME, Fernandez FM, Kubanek J (2009) Desorption electrospray ionization mass spectrometry reveals surface-mediated antifungal chemical defense of a tropical seaweed. Proc Natl Acad Sci 106:7314–7319. doi: 10.1073/pnas.0812020106 PubMedPubMedCentralGoogle Scholar
  58. LaSarre B, Federle MJ (2013) Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77:73–111. doi: 10.1128/MMBR.00046-12 PubMedPubMedCentralGoogle Scholar
  59. Lee J, Jayaraman A, Wood TK (2007) Indole is an inter-species biofilm signal mediated by SdiA. BMC Microbiol 7:42. doi: 10.1186/1471-2180-7-42 PubMedPubMedCentralGoogle Scholar
  60. Lee J, Attila C, Cirillo SL, Cirillo JD, Wood TK (2012) Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence. Microb Biotechnol 2:75–90. doi: 10.1111/j.1751-7915.2008.00061.x Google Scholar
  61. Leroy C, Delbarre C, Ghillebaert F, Compere C, Combes D (2008) Effects of commercial enzymes on the adhesion of a marine biofilm-forming bacterium. Biofouling 24:11–22. doi: 10.1080/08927010701784912 PubMedGoogle Scholar
  62. Li L, Hooi D, Chhabra SR, Pritchard D, Shaw PE (2004) Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. Oncogene 23:4894–4902. doi: 10.1038/sj.onc.1207612 PubMedGoogle Scholar
  63. Lu TK, Collins JJ (2007) Dispersing biofilms with engineered enzymatic bacteriophage. Proc Natl Acad Sci 104:11197–11202. doi: 10.1073/pnas.0704624104 PubMedPubMedCentralGoogle Scholar
  64. Mahanty A, Mishra S, Bosu R, Maurya UK, Netam SP, Sarkar B (2013) Phytoextracts-synthesized silver nanoparticles inhibit bacterial fish pathogen Aeromonas hydrophila. Indian J Microbiol 53:438–446. doi: 10.1007/s12088-013-0409-9 PubMedGoogle Scholar
  65. Malaeb L, Le-Clech P, Vrouwenvelder JS, Ayoub GM, Saikaly PE (2013) Do biological-based strategies hold promise to biofouling control in MBRs? Water Res 47:5447–5463. doi: 10.1016/j.watres.2013.06.033 PubMedGoogle Scholar
  66. Marketon MM, Glenn SA, Eberhard A, González JE (2003) Quorum sensing controls exopolysaccharide production in Sinorhizobium meliloti. J Bacteriol 185:325–331. doi: 10.1128/JB.185.1.325-331.2003 PubMedPubMedCentralGoogle Scholar
  67. Martinez LR, Fries BC (2010) Fungal biofilms: relevance in the setting of human disease. Curr Fungal Infect Rep 4:266–275. doi: 10.1007/s12281-010-0035-5 PubMedPubMedCentralGoogle Scholar
  68. Mayville P, Ji G, Beavis R, Yang H, Goger M, Novick RP, Muir TW (1999) Structure–activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc Natl Acad Sci USA 96:1218–1223. doi: 10.1073/pnas.96.4.1218 PubMedPubMedCentralGoogle Scholar
  69. Morohoshi T, Ebata A, Nakazawa S, Kato N, Ikeda T (2005) N-Acylhomoserine lactone-producing or -degrading bacteria isolated from the intestinal microbial flora of Ayu fish (Plecoglossus altivelis). Microbes Environ 20:264–268Google Scholar
  70. Morohoshi T, Nakazawa S, Ebata A, Kato N, Ikeda T (2008) Identification and characterization of N-acylhomoserine lactone-acylase from the fish intestinal Shewanella sp. strain MIB015. Biosci Biotechnol Biochem 72:1887–1893. doi: 10.1271/bbb.80139 PubMedGoogle Scholar
  71. Natrah FMI, Defoirdt T, Sorgeloos P, Bossier P (2011) Disruption of bacterial cell-to-cell communication by marine organisms and its relevance to aquaculture. Marine Biotechnol 13:109–126. doi: 10.1007/s10126-010-9346-3 Google Scholar
  72. Nhan DT, Cam DTV, Wille M, Defoirdt T, Bossier P, Sorgeloos P (2010) Quroum quenching bacteria protect Macrobrachium rosenbergii larvae from Vibrio harveyi infection. J Appl Microbiol 109:1007–1016. doi: 10.1111/j.1365-2672.2010.04728.x PubMedGoogle Scholar
  73. Nylund GM, Cervin G, Hermansson M, Pavia H (2005) Chemical inhibition of bacterial colonization by the red alga Bonnemaisonia hamifera. Mar Ecol Prog Ser 302:27–36Google Scholar
  74. Nylund GM, Cervin G, Persson F, Hermansson M, Steinberg PD, Pavia H (2008) Seaweed defence against bacteria: a poly-brominated 2-heptanone from the red alga Bonnemaisonia hamifera inhibits bacterial colonisation. Mar Ecol Prog Ser 369:39–50. doi: 10.3354/meps07577 Google Scholar
  75. Nylund GM, Persson F, Lindegarth M, Cervin G, Hermansson M, Pavia H (2010) The red alga Bonnemaisonia asparagoides regulates epiphytic bacterial abundance and community composition by chemical defence. FEMS Microbiol Ecol 71:84–93. doi: 10.1111/j.1574-6941.2009.00791.x PubMedGoogle Scholar
  76. Oliver CM, Schaefer AL, Greenberg EP, Sufrin JR (2009) Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa. J Med Chem 52:1569–1575. doi: 10.1021/jm8015377 PubMedGoogle Scholar
  77. Pathak R, Kumar R, Gautam HK (2013) Cross-species induction and enhancement of antimicrobial properties in response to gamma irradiation in Exiguobacterium sp. HKG 126. Indian J Microbiol 53:130–136. doi: 10.1007/s12088-013-0369-0 PubMedPubMedCentralGoogle Scholar
  78. Paul NA, Cole L, de Nys R, Steinberg PD (2006a) Ultra structure of the gland cells of the red alga Asparagopsis armata (Bonnemaisoniaceae). J Phycol 42:637–645. doi: 10.1111/j.1529-8817.2006.00226.x Google Scholar
  79. Paul NA, de Nys R, Steinberg PD (2006b) Chemical defence against bacteria in red alga Asparagopsis armata linking structure with function. Mar Ecol Prog Ser 306:87–101. doi: 10.3354/meps306087 Google Scholar
  80. Paul D, Kim YS, Ponnusamy K, Kweon JH (2009) Application of quorum quenching to inhibit biofilm fermentation. Environ Eng Sci 26:1319–1324. doi: 10.1089/ees.2008.0392 Google Scholar
  81. Peters L, König GM, Wright AD, Pukall R, Stackebrandt E, Eberl L, Riedel K (2003) Secondary metabolites of Flustra foliacea and their influence on bacteria. Appl Environ Microbiol 69:3469–3475. doi: 10.1128/AEM.69.6.3469-3475.2003 PubMedPubMedCentralGoogle Scholar
  82. Qian PY, Lau SCK, Dahms HU, Dobretsov S, Harder T (2007) Marine biofilms as mediators of colonization by marine macroorganisms: implications for antifouling and aquaculture. Marine Biotechnol 9:399–410. doi: 10.1007/s10126-007-9001-9 Google Scholar
  83. Quinones B, Pujol CJ, Lindow SE (2004) Regulation of AHL production and its contribution to epiphytic fitness in Pseudomonas syringae. Mol Plant Microbe Interact 17:521–531. doi: 10.1094/MPMI.2004.17.5.521 PubMedGoogle Scholar
  84. Rasch M, Buch C, Austin B, Slierendrecht WJ, Ekmann KS, Larsen JL, Johansen C, Riedel K, Eberl L, Givskov M, Gram L (2004) An inhibitor of bacterial quorum sensing reduces mortalities caused by Vibriosis in Rainbow trout (Oncorhynchus mykiss, Walbaum). Syst Appl Microbiol 27:350–359. doi: 10.1078/0723-2020-00268 PubMedGoogle Scholar
  85. Rasmussen TB, Bjarnsholt T, Skindersoe ME, Hentzer M, Kristoffersen P, Köte M, Nielsen J, Eberl L, Givskov M (2005) Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J Bacteriol 187:1799–1814. doi: 10.1128/JB.187.5.1799-1814.2005 PubMedPubMedCentralGoogle Scholar
  86. Romero M, Avendaño-Herrera R, Magariños B, Cámara M, Otero A (2010) Acylhomoserine lactone production and degradation by the fish pathogen Tenacibaculum maritimum, a member of the Cytophaga-Flavobacterium-Bacteroides (CFB) group. FEMS Microbiol Lett 304:131–139. doi: 10.1111/j.1574-6968.2009.01889.x PubMedGoogle Scholar
  87. Shang Z, Wang H, Zhou S, Chu W (2014) Characterization of N-Acyl-homoserine lactones (AHLs)-deficient clinical isolates of Pseudomonas aeruginosa. Indian J Microbiol 54:158–162. doi: 10.1007/s12088-014-0449-9 Google Scholar
  88. Sheng L, Pu M, Hegde M, Zhang Y, Jayaraman A, Wood TK (2012) Interkingdom adenosine signal reduces Pseudomonas aeruginosa pathogenicity. Microb Biotechnol 2:560–572. doi: 10.1111/j.1751-7915.2012.00338.x Google Scholar
  89. Skjerma J, Vadstein O (1993) Characterization of the bacterial flora of mass cultivated Brachionus plicatilis. Hydrobiologia 255:185–191Google Scholar
  90. Smith MD, Roheim CA, Crowder LB, Halpern BS, Turnipseed M, Anderson JL, Asche F, Bourillón L, Guttormsen AG, Kahn A, Liguori LA, McNevin A, O’Connor M, Squires D, Tyedemers P, Brownstein C, Carden K, Klinger DH, Sagarin R, Selkoe KA (2010) Sustainability and global seafood. Science 327:784–786. doi: 10.1126/science.1185345 PubMedGoogle Scholar
  91. Smyth AR, Cifelli PM, Ortori CA, Righetti K, Lewis S, Erskine P, Holland ED, Givskov M, Williams P, Cámara M, Barrett DA, Knox A (2010) Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis – a pilot randomized controlled trial. Pediatr Pulmonol 45:356–362. doi: 10.1002/ppul.21193 PubMedGoogle Scholar
  92. Stamper DM, Walch M, Jacobs RN (2003) Bacterial population changes in a membrane bioreactor for graywater treatment monitored by denaturing gradient gel electrophoretic analysis of 16S rRNA gene fragments. Appl Environ Microbiol 69:852–860. doi: 10.1128/AEM.69.2.852-860.2003 PubMedPubMedCentralGoogle Scholar
  93. Stoltz DA, Ozer EA, Taft PJ, Barry M, Liu L, Kiss PJ, Moninger TO, Parsek MR, Zabner J (2008) Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. J Clin Invest 118:3123–3131. doi: 10.1172/JCI35147 PubMedPubMedCentralGoogle Scholar
  94. Swift S, Karlyshev AV, Fish L, Durant EL, Winson MK, Chhabra SR, Williams P, Macintyre S, Stewart GS (1997) Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules. J Bacteriol 179:5271–5281PubMedPubMedCentralGoogle Scholar
  95. Teasdale ME, Liu J, Wallace J, Akhlaghi F, Rowley DC (2009) Secondary metabolites produced by marine bacterium Halobacillus salinus that inhibit quorum sensing controlled phenotypes in gram-negative bacteria. Appl Environ Microbiol 75:567–572. doi: 10.1128/AEM.00632-08 PubMedPubMedCentralGoogle Scholar
  96. Teplitski M, Robinson JB, Bauer WD (2000) Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria. Mol Plant Microbe Interact 13:637–648. doi: 10.1094/MPMI.2000.13.6.637 PubMedGoogle Scholar
  97. Thammavongsa V, Kern JW, Missiakas DM, Schneewind O (2009) Staphylococcus aureus synthesizes adenosine to escape host immune responses. J Exp Med 206:2417–2427. doi: 10.1084/jem.20090097 PubMedPubMedCentralGoogle Scholar
  98. Tinh NT, Asanka Gunasekara RA, Boon N, Dierckens K, Sorgeloos P, Bossier P (2007a) N-acyl homoserine lactone-degrading microbial enrichment cultures isolated from Penaeus vannamei shrimp gut and their probiotic properties in Brachionus plicatilis cultures. FEMS Microbiol Ecol 62:45–53. doi: 10.1111/j.1574-6941.2007.00378.x PubMedGoogle Scholar
  99. Tinh NTN, Lin ND, Wood TK, Dierckens K, Sorgeloos P, Bossier P (2007b) Interference with the quorum sensing systems in a Vibrio harveyi strain alters the growth rate of gnotobiotically cultured rotifer Brachionus plicatilis. J Appl Microbiol 103:194–203. doi: 10.1111/j.1365-2672.2006.03217.x PubMedGoogle Scholar
  100. Tinh NTN, Yen VHN, Dierckens K, Sorgeloos P, Bossier P (2008) An acyl homoserine lactone-degrading microbial community improves the survival of first-feeding turbot larvae (Scophthalmus maximus L.). Aquaculture 285:56–62. doi: 10.1016/j.aquaculture.2008.08.018 Google Scholar
  101. Tinh NTN, Dung NV, Trung CT (2013) In vitro characterization of a recombinant AHL-Lactonase from Bacillus cereus isolated from a striped catfish (Pangasianodon hypophthalmus) pond. Indian J Microbiol 53:485–487. doi: 10.1007/s12088-013-0415-y PubMedGoogle Scholar
  102. Tonello F, Zornetta I (2012) Bacillus anthracis factors for phagosomal escape. Toxins 4:536–553. doi: 10.3390/toxins4070536 PubMedPubMedCentralGoogle Scholar
  103. Ulrich RL (2004) Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis. Appl Environ Microbiol 70:6173–6180. doi: 10.1128/AEM.70.10.6173-6180.2004 PubMedPubMedCentralGoogle Scholar
  104. Vejborg RM, Klemm P (2008) Blocking of bacterial biofilm formation by a fish protein coating. Appl Environ Microbiol 74:3551–3558. doi: 10.1128/AEM.00279-08 PubMedPubMedCentralGoogle Scholar
  105. Wang LH, Weng LX, Dong YH, Zhang LH (2004) Specificity and enzyme kinetics of the quorum quenching N-acyl homoserine lactone lactonase (AHL lactonase). J Biol Chem 14:13645–13651. doi: 10.1074/jbc.M311194200 Google Scholar
  106. Wang WZ, Morohoshi T, Ikenoya M, Somaya N, Ikeda T (2010) AiiM, a novel class of N-acylhomoserine lactonase from the leaf-associated bacterium Microbacterium testaceum. Appl Environ Microbiol 76:2524–2530. doi: 10.1128/AEM.02738-09 PubMedPubMedCentralGoogle Scholar
  107. Wang H, Tu F, Gui Z, Lu X, Chu W (2013) Antibiotic resistance profiles and quorum sensing-dependent virulence factors in clinical isolates of Pseudomonas aeruginosa. Indian J Microbiol 53:163–167. doi: 10.1007/s12088-013-0370-7 PubMedPubMedCentralGoogle Scholar
  108. Wood TK (2009) Insights on Escherichia coli biofilm formation and inhibition from whole‐transcriptome profiling. Environ Microbiol 11:1–15. doi: 10.1111/j.1462-2920.2008.01768.x PubMedPubMedCentralGoogle Scholar
  109. Yang F, Wang LH, Wang J, Dong YH, Hu JY, Zhang LH (2005) Quorum quenching enzyme activity is widely conserved in the sera of mammalian species. FEBS Lett 579:3713–3717. doi: 10.1016/j.febslet.2005.05.060 PubMedGoogle Scholar
  110. Yao Y, Martinez-Yamout MA, Dickerson TJ, Brogan AP, Wright PE, Dyson HJ (2006) Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones. J Mol Biol 355:262–273. doi: 10.1016/j.jmb.2005.10.041 PubMedGoogle Scholar
  111. Ye JH, Rajendran VM (2009) Adenosine: an immune modulator of inflammatory bowel diseases. World J Gastroenterol 15:4491–4498. doi: 10.3748/wjg.15.4491 PubMedPubMedCentralGoogle Scholar
  112. Yeon K-M, Cheong W-S, Oh H-S, Lee W-N, Hwang B-K, Lee C-H, Beyenal H, Lewandowski Z (2009a) Quorum sensing: a new biofouling control paradigm in a membrane bioreactor for advanced waste water treatment. Environ Sci Technol 43:380–385. doi: 10.1021/es8019275 PubMedGoogle Scholar
  113. Yeon K-M, Lee C-H, Kim J (2009b) Magnetic enzyme carrier for effective biofouling control in the membrane bioreactor based on enzymatic quorum quenching. Environ Sci Technol 43:7403–7409. doi: 10.1021/es901323k PubMedGoogle Scholar
  114. Zhang Y, Zhang Y, Yang Y, Wang L, Weng L (2013) Identification of a Pseudomonas sp. that inhibits RHL system of quorum sensing. Indian J Microbiol 53:28–35. doi: 10.1007/s12088-012-0340-5 PubMedPubMedCentralGoogle Scholar
  115. Zhang J, Chen YP, Miller KP, Ganewatta MS, Bam M, Yan L, Nagarkatti M, Decho AW, Tang C (2014) Antimicrobial metallopolymers and their bioconjugates with conventional antibiotics against multidrug-resistant bacteria. J Am Chem Soc 136:4873–4876. doi: 10.1021/ja5011338 PubMedGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Microbial Biotechnology and GenomicsCSIR-Institute of Genomics and Integrative BiologyDelhiIndia

Personalised recommendations