Potential Applications of Quorum Sensing Inhibitors in Diverse Fields

  • Vipin C. Kalia
  • Prasun Kumar


All organisms are susceptible to attack by other organisms, and it may even spell death for the recipient. However, each organism is also bestowed with an inherent ability to protect itself by developing self-defence mechanisms. Human beings have a strong immune system but are quite susceptible to infections by fungi, bacteria and viruses. Microbial infections have been a constant worry for health departments (Kalia 2013, 2014). The economy of a nation is dramatically affected by the health of its residents. The discovery of antibiotics was a great boon to mankind. However, microbes have been developing resistance against antibiotics. So much so that during the last seven to eight decades, there has been a need to find new antibiotics. Now the scenario is quite depressing as almost all antibiotics are proving ineffective. The evolution of multidrug resistance among pathogenic microbes has taken a new dimension (Davies and Davies 2010). Bacteria expressing their virulent behaviour through the phenomenon of quorum sensing (QS) develop a biofilm. Bacteria inside the biofilm are up to 1000 times more resistant to antibiotics compared to their planktonic counterparts (Kalia et al. 2014a, b). Research efforts during the last four decades have brought hope by providing alternatives and supplements to antibiotics. Quorum sensing inhibitors (QSIs) are seen as novel drugs especially against infectious bacteria. Although, the search for QSIs was intended for helping human beings to fight against diseases, the applications can be extended to other fields as well: agriculture, aquaculture, water treatment, fisheries, etc. A few examples of applications of QSIs have been described below (Table 1).


Quorum Sense Kojic Acid Quorum Sense System Quorum Sense Signal Quorum Quenching 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Acyl homoserine lactone


Homoserine lactone




3-oxo-N-dodecanoyl- HSL


Quorum quenching


Quorum sensing


Quorum sensing inhibitors


Quorum sensing systems



The authors wish to thank the director of CSIR-Institute of Genomics and Integrative Biology (IGIB), CSIR-INDEPTH (BSC0111), Government of India, for providing the necessary funds and facilities. PK is thankful to CSIR for granting Senior Research Fellowship.


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Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Microbial Biotechnology and GenomicsCSIR-Institute of Genomics and Integrative BiologyDelhiIndia

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