Alternative Strategies to Target Quorum Sensing (QS): Combination of QS Inhibitors with Antibiotics and Nanotechnological Approaches
Several antibiotics possess, beyond their conventional mechanism of antibacterial action, secondary functions which inhibit bacterial pathogenesis. One such secondary action is that of inhibiting quorum sensing in bacteria. Furthermore, there are certain drugs and natural molecules which do not possess antibacterial action but possess functions which perturb quorum sensing in bacteria. The first part of this chapter deals with the quorum-quenching action of some well-known drugs and their synergy with quorum-sensing inhibitors (QSIs). The latter part of this chapter touches upon the promising avenues being laid down by nanotechnology toward curbing quorum sensing. As no quorum-sensing inhibitors have progressed to phase II clinical trials, we believe the alternative strategies discussed in this chapter may pave the way for future directions in the field.
KeywordsQuorum Sense Ellagic Acid Quorum Sense System Penicillic Acid Quorum Sense Inhibition
- Hentzer M, Wu H, Andersen JB, Riedel K, Rasmussen TB, Bagge N, Kumar N, Schembri MA, Song Z, Kristoffersen P, Manefield M, Costerton JW, Molin S, Eberl L, Steinberg P, Kjelleberg S, Hoiby N, Givskov M (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. Embo J 22(15):3803–3815PubMedCrossRefPubMedCentralGoogle Scholar
- Zeng X, Liu X, Bian J, Pei G, Dai H, Polyak SW, Song F, Ma L, Wang Y, Zhang L (2011) Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa. Antimicrob Agents Chemother 55(6):3015–3017PubMedCrossRefPubMedCentralGoogle Scholar