Alternative Strategies to Target Quorum Sensing (QS): Combination of QS Inhibitors with Antibiotics and Nanotechnological Approaches

  • Divakara S. S. M. Uppu
  • Chandradhish Ghosh
  • Jayanta Haldar


Several antibiotics possess, beyond their conventional mechanism of antibacterial action, secondary functions which inhibit bacterial pathogenesis. One such secondary action is that of inhibiting quorum sensing in bacteria. Furthermore, there are certain drugs and natural molecules which do not possess antibacterial action but possess functions which perturb quorum sensing in bacteria. The first part of this chapter deals with the quorum-quenching action of some well-known drugs and their synergy with quorum-sensing inhibitors (QSIs). The latter part of this chapter touches upon the promising avenues being laid down by nanotechnology toward curbing quorum sensing. As no quorum-sensing inhibitors have progressed to phase II clinical trials, we believe the alternative strategies discussed in this chapter may pave the way for future directions in the field.


Quorum Sense Ellagic Acid Quorum Sense System Penicillic Acid Quorum Sense Inhibition 
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Copyright information

© Springer India 2015

Authors and Affiliations

  • Divakara S. S. M. Uppu
    • 1
  • Chandradhish Ghosh
    • 1
  • Jayanta Haldar
    • 1
  1. 1.Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry UnitJawaharlal Nehru Centre for Advanced Scientific ResearchBengaluruIndia

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