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Alternative Strategies to Target Quorum Sensing (QS): Combination of QS Inhibitors with Antibiotics and Nanotechnological Approaches

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Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight

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Abstract

Several antibiotics possess, beyond their conventional mechanism of antibacterial action, secondary functions which inhibit bacterial pathogenesis. One such secondary action is that of inhibiting quorum sensing in bacteria. Furthermore, there are certain drugs and natural molecules which do not possess antibacterial action but possess functions which perturb quorum sensing in bacteria. The first part of this chapter deals with the quorum-quenching action of some well-known drugs and their synergy with quorum-sensing inhibitors (QSIs). The latter part of this chapter touches upon the promising avenues being laid down by nanotechnology toward curbing quorum sensing. As no quorum-sensing inhibitors have progressed to phase II clinical trials, we believe the alternative strategies discussed in this chapter may pave the way for future directions in the field.

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Authors and Affiliations

  1. Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru, 560064, Karnataka, India

    Divakara S. S. M. Uppu, Chandradhish Ghosh & Jayanta Haldar

Authors
  1. Divakara S. S. M. Uppu
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  2. Chandradhish Ghosh
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  3. Jayanta Haldar
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Correspondence to Jayanta Haldar .

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Editors and Affiliations

  1. CSIR-Institute of Genomics and Integrative Biology, Microbial Biotechnology and Genomics, Delhi, India

    Vipin Chandra Kalia

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Uppu, D.S.S.M., Ghosh, C., Haldar, J. (2015). Alternative Strategies to Target Quorum Sensing (QS): Combination of QS Inhibitors with Antibiotics and Nanotechnological Approaches. In: Kalia, V. (eds) Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1982-8_27

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