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Synthetic Quorum Sensing Inhibitors: Signal Analogues

  • Dimpy Kalia
Chapter

Abstract

Bacterial cells possess a unique ability to communicate with each other by utilizing small organic molecules they synthesize. This phenomenon is commonly referred to as quorum sensing and plays a major role in orchestrating bacterial virulence and in the development of bacterial resistance to antibiotics. Therefore, synthetic small organic molecules that interfere with bacterial quorum-sensing networks have a tremendous potential to serve as antibacterial agents. This strategy is especially desirable as it may lead to developing antibacterial agents that operate by imposing lesser selective pressure on bacteria to develop resistant strains as compared to traditional antibiotics which have given rise to highly drug-resistant bacterial strains that have become a major global threat to human health. The development of such synthetic quorum-sensing inhibitors is the major focus of several academic and industrial research laboratories all over the world. This chapter outlines some of the highlights of these efforts with a major emphasis on summarizing the key discoveries pertaining to the structure-activity relationships of the compounds tested. I anticipate that this compendium will serve as a guideline for the design and discovery of new quorum-sensing inhibitors for antibacterial therapeutic applications.

Keywords

Acyl Chain Quorum Sense Antagonistic Activity Agonistic Activity Lactone Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.DST-INSPIRE Faculty, Department of ChemistryUniversity of PunePuneIndia

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