Caenorhabditis elegans as an In Vivo Non-Mammalian Model System to Study Quorum Sensing in Pathogens

  • Sajal Sarabhai
  • Neena Capalash
  • Prince Sharma


Indiscriminate use of antibiotics has led to the emergence of multiple drug-resistant pathogens. Quorum sensing (QS) is an intercellular communication system which is widely present in pathogens regulating the virulence genes expression and pathogenesis in host. Interruption of QS regulatory system is an attractive strategy to attenuate pathogens’ virulence. Several synthetic and natural compounds with potential QS inhibitory activity have been identified and tested in vitro for their inhibitory activity. To study the in vivo efficacy of the compounds, a model organism is required. Unlike other vertebrate model organisms like mouse or rabbit, C. elegans has emerged as a simple, amenable, genetically tractable worm for studying QS inhibitory activity of compounds. This chapter focuses on the advantages and recent development in using C. elegans as a non-mammalian in vivo model system.


Quorum Sensing Quorum Sensing Inhibitor Quorum Sensing Regulation Quorum Sensing Signalling Molecule Slow Killing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Department of MicrobiologyPanjab UniversityChandigarhIndia
  2. 2.Department of BiotechnologyPanjab UniversityChandigarhIndia

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