Quorum-Sensing Systems in Enterococci
Enterococcus is a genus of Gram-positive bacteria that is ubiquitous in natural ecosystems, plants, and animals. Some species of Enterococcus are present in the normal gastrointestinal bacterial community. However, others notably Enterococcus faecalis and Enterococcus faecium often cause opportunistic infections such as bacteremia, endocarditis, urinary tract infections, posttreatment endodontic infections, and endophthalmitis (Arias et al. 2010). Bacteria often use quorum sensing (QS) systems to control the expression of certain virulence genes and establish infection efficiently (Waters and Bassler 2005).
KeywordsQuorum Sense Quorum Sense System Quorum Sense Inhibitor Quorum Sense Gene Complex Microbiota
This research was supported in part by Grants-in-Aid for Scientific Research (B) No. 24380050 and Grant-in-Aid for JSPS Fellows No. 25–03389.
- Bourgogne A, Hilsenbeck SG, Dunny GM, Murray BE (2006) Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease. J Bacteriol 188:2875–2884PubMedCrossRefPubMedCentralGoogle Scholar
- Clewell DB, Weaver KE, Dunny GM, Coque TM, Francia MV, Hayes F (2014) Extrachromosomal and mobile elements in enterococci: transmission, maintenance, and epidemiology. In: Clewell DB, Shankar N, Ike Y, Gilmore M (eds) Enterococci: from commensals to leading causes of drug resistant infection [Internet]. Massachusetts Eye and Ear Infirmary, BostonGoogle Scholar
- Hirt H, Erlandsen SL, Dunny GM (2000) Heterologous inducible expression of Enterococcus faecalis pCF10 aggregation substance Asc10 in Lactococcus lactis and Streptococcus gordonii contributes to cell hydrophobicity and adhesion to fibrin. J Bacteriol 182:2299–2306PubMedCrossRefPubMedCentralGoogle Scholar
- Nakayama J, Yoshida K, Kobayashi H, Isogai A, Clewell DB, Suzuki A (1995) Cloning and characterization of a region of Enterococcus faecalis plasmid pPD1 encoding pheromone inhibitor (ipd), pheromone sensitivity (traC), and pheromone shutdown (traB) genes. J Bacteriol 177:5567–5573PubMedPubMedCentralGoogle Scholar
- Nakayama J, Horii T, Suzuki A (1999) Bacterial peptide pheromone is imported where it directly binds to an intracellular receptor. In: Proceedings of the 1st international peptide symposium 1997, in press. Kluwer Academic Publishers, BV, Dordrecht, pp 215–217Google Scholar
- Nakayama J, Kariyama R, Kumon H (2002) Description of a 23.9-kilobase chromosomal deletion containing a region encoding fsr genes which mainly determines the gelatinase-negative phenotype of clinical isolates of Enterococcus faecalis in urine. Appl Environ Microbiol 68:3152–3155PubMedCrossRefPubMedCentralGoogle Scholar
- Nakayama J, Chen S, Oyama N, Nishiguchi K, Azab EA, Tanaka E, Kariyama R, Sonomoto K (2006) Revised model for Enterococcus faecalis fsr quorum-sensing system: the small open reading frame fsrD encodes the gelatinase biosynthesis-activating pheromone propeptide corresponding to staphylococcal AgrD. J Bacteriol 188:8321–8326PubMedCrossRefPubMedCentralGoogle Scholar
- Pinkston KL, Gao P, Diaz-Garcia D, Sillanpää J, Nallapareddy SR, Murray BE, Harvey BR (2011) The Fsr quorum-sensing system of Enterococcus faecalis modulates surface display of the collagen-binding MSCRAMM Ace through regulation of gelE. J Bacteriol 193:4317–4325PubMedCrossRefPubMedCentralGoogle Scholar
- Strzelecki J, Hryniewicz W, Sadowy E (2011) Gelatinase-associated phenotypes and genotypes among clinical isolates of Enterococcus faecalis in Poland. Polish J Microbiol 60:287–292Google Scholar