Abstract
Quorum sensing (QS) is an intercellular communication system by which bacterial cells are capable of indirectly monitoring their own population density through production and exchange of diffusible signal molecules. This enables bacteria to control gene expression dependent on population size and thereby perform coordinated phenotypic changes in a multicellular fashion. At present, QS regulatory systems have been reported for Gram-positive and Gram-negative bacteria. These systems rely on two major components, a small diffusible signalling molecule which accumulates in a population density-dependent manner and a transcriptional activator protein which, in concert with the signalling molecule, activates the expression of relevant genes. For Gram negatives, they employ N-acyl homoserine lactones (acyl HLs, AHLs) as the signalling molecule. AHL synthase encoded by LuxI homolog synthesizes AHL molecules. Short side-chain AHLs diffuse freely across cell membranes, whereas long side-chain AHLs have to use active efflux to partition to the membrane (Pearson et al. 1999). Upon reaching a threshold concentration in the extracellular medium, AHL molecules are perceived by cytoplasmic LuxR family proteins to regulate the downstream processes (Parsek and Greenberg 2000). As a consequence, expression of certain functions, often virulence factors required for pathogenesis, is triggered at high population densities in a coordinated manner.
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References
Bi ZX, Liu YJ, Lu CP (2007) Contribution of AhyR to virulence of Aeromonas hydrophila J-1. Res Vet Sci 83:150–156
Cao YA, He SX, Zhou ZG, Zhang MC, Mao W, Zhang HT, Yao B (2012) Orally administered thermostable N-acyl homoserine lactones from Bacillus sp strain AI96 attenuates Aeromonas hydrophila infection in zebrafish. Appl Environ Microbiol 78:1899–1908. doi:10.1128/AEM.06139-11
Chan KG, Puthucheary SD, Chan XY, Yin WF, Wong CS, Too WS, Chua KH (2011) Quorum sensing in Aeromonas species isolated from patients in Malaysia. Curr Microbiol 62(1):167–172
Chu WH, Lu F, Zhu W, Kang CT (2010) Isolation and characterization of new potential probiotic bacteria based on Quorum sensing system. J Appl Microbiol 110:202–208
Chu WH, Jiang Y, Liu YW, Zhu W (2011) Role of the quorum sensing system in biofilm formation and virulence of Aeromonas hydrophila. Afr J Microbiol Res 5(32):5819–5825
Chu WH, Liu YW, Jiang Y, Zhu W, Zhuang XY (2013) Production of N-acyl Homoserine Lactones and virulence factors of waterborne Aeromonas hydrophila. Ind J Microbiol 53(3):264–268
Defoirdt T (2013) Antivirulence therapy for animal production: filling an arsenal with novel weapons for sustainable disease control. PLoS Pathog 9(10):e1003603. doi:10.1371/journal.ppat.1003603
Feng L, Wu ZY, Yu X (2013) Quorum sensing in water and wastewater treatment biofilms. J Environ Biol 34:437–444
Galloway WR, Hodgkinson JT, Bowden SD, Welch M, Spring DR (2011) Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. Chem Rev 111(1):28–67
Husain FM, Ahmad I, Asif M, Tahseen Q (2013) Influence of clove oil on certain quorum-sensing-regulated functions and biofilm of Pseudomonas aeruginosa and Aeromonas hydrophila. J Biosci 38: 835–844. doi: 10.1007/s12038-013-9385-9
Igbinosa IH, Igumbor EU, Aghdasi F, Tom M, Okoh AI (2012) Emerging Aeromonas species infections and their significance in public health. Scientific World Journal 2012:625023. doi:10.1100/2012/625023
Jahid IK, Lee NA, Kim A, Ha SD (2013) Influence of glucose concentrations on biofilm formation, motility, exoprotease production, and quorum sensing in Aeromonas hydrophila. J Food Prot 76(2):239–247
Janda JM, Abbott SL (2010) The genus Aeromonas: taxonomy, pathogenicity, and infection. Clin Microbiol Rev 23(1):35–73
Jangid K, Parameswaran PS, Shouche YS (2012) A variant quorum sensing system in A. veronii MTCC 3249. Sensors 12: 3814–3830. doi:10.3390/s120403814
Khajanchi BK, Sha J, Kozlova EV, Erova TE, Suarez G, Sierra JC, Popov VL, Horneman AJ, Chopra AK (2009) N-Acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila. Microbiology 155(11):3518–3531
Lynch MJ, Swift S, Kirke DF, Keevil CW, Dodd CE, Williams P (2002) The regulation of biofilm development by quorum sensing in Aeromonas hydrophila. Environ Microbiol 4(1):18–28
Martin-Carnahan A, Joseph SW (2005) Genus I. Aeromonas Stanier 1943, 213AL. In: Brenner DJ, Krieg NR, Staley JT, Garrity GM (ed) Bergey’s manual of systematic bacteriology, 2nd edn, vol 2, part B. Springer, New York, NY, p 557–578
Myszka K, Czaczyk K (2012) N-Acylhomoserine Lactones (AHLs) as phenotype control factors produced by gram-negative bacteria in natural ecosystems. Pol J Environ Stud 21(1):15–21
Natrah FM, Alam MI, Pawar S, Harzevili AS, Nevejan N, Boon N, Sorgeloos P, Bossier P, Defoirdt T (2012) The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae. Vet Microbiol 159(1–2):77–82
Parsek MR, Greenberg EP (2000) Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc Natl Acad Sci U S A 97:8789–8793
Pearson KG, Fouad K, Misiaszek JE (1999) Adaptive changes in motor activity associated with functional recovery following muscle denervation in walking cats. J Neurophysiol 82:370–381
Pemberton JM, Stephen PK, Radomir S (1997) Secreted enzymes of Aeromonas. FEMS Microbiol Lett 152:1–10
Ponnusamy K, Paul D, Kweon JH (2009) Inhibition of quorum sensing mechanism and Aeromonas hydrophila biofilm formation by Vanillin. Environ Eng Sci 26(8):1359–1363. doi:10.1089/ees.2008.0415
Ponnusamy K, Paul D, Kim YS, Kweon JH (2010) 2(5H)-Furanone: a prospective strategy for biofouling-control in membrane biofilm bacteria by quorum sensing inhibition. Braz J Microbiol 41:227–234
Schwenteit J, Gram L, Nielsen KF, Fridjonsson OH, Bornscheuer UT, Givskov M, Gudmundsdottir BK (2011) Quorum sensing in Aeromonas salmonicida subsp. achromogenes and the effect of the autoinducer synthase AsaI on bacterial virulence. Vet Microbiol. 27;147(3–4):389–397.
Sha J, Pillai L, Fadl AA, Galindo CL, Erova TE, Chopra AK (2005) The type III secretion system and cytotoxic enterotoxin alter the virulence of Aeromonas hydrophila. Infect Immun 73:6446–6457
Swift S, Karlyshev AV, Fish L, Durant EL and others (1997) Quorum sensing in A. hydrophila and A. salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules. J Bacteriol 179:5271–5281
Swift S, Lynch MJ, Fish L, Kirke DF, Tomás JM, Stewart GS, Williams P (1999) Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila. Infect Immun 67(10):5192–5199
Vivas J, Razquin BE, López-Fierro P, Naharro G, Villena A (2004) Correlation between production of acyl homoserine lactones and proteases in an Aeromonas hydrophila aroA live vaccine. Vet Microbiol 101(3):167–176
Whitehead NA, Barnard AML, Slater H, Simpson NJL, Salmond GPC (2001) Quorum sensing in Gram-negative bacteria. FEMS Microbiol Rev 25:365–404
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Chu, W., Zhu, W., Zhuang, X. (2015). Quorum Sensing Systems in Aeromonas spp.. In: Kalia, V. (eds) Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1982-8_11
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DOI: https://doi.org/10.1007/978-81-322-1982-8_11
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