Nanomaterials in Healthcare

  • Thomas Tumillo
  • Avijit Roy
  • Sahana Pentyala
  • Pooja Mysore
  • Srinivas N. Pentyala


The strength of a nation invariably depends upon the strength of every individual. Healthy citizens make a healthy and strong society. As a society, we started looking at expensive macroscopic high-tech solutions to solve many of our problems. With growing interests in the field of nanotechnology, looking microscopically at the problem to come up with solutions has generated a paradigm shift. Nanomaterials are currently being used in every branch of science, and particularly their use in healthcare opened up a new horizon to provide quality care to patients. The tools and therapies for diagnosis and prognosis of diseases and symptoms revolve around three important aspects – diagnostics, devices and drugs. Nanomaterial applications are now found in all these three aspects and are being effectively used in health care. New discoveries and inventions in the field of nanohealth care point to a bright future for the wellbeing of mankind. An introduction to nanomaterials in healthcare has been presented in this review.


Graphene Oxide Fluorescence Resonance Energy Transfer PEGylated Liposomal Doxorubicin Fluorescence Resonance Energy Transfer Signal Rapid Diagnostics 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Angeli E, Buzio R, Firpo G, Magrassi R, Mussi V, Repetto L, Valbusa U (2008) Nanotechnology applications in medicine. Tumori 94:206–215PubMedGoogle Scholar
  2. 2.
    Kustandi TS, Loh WW, Shen L, Low HY (2013) Reversible recovery of nanoimprinted polymer structures. Langmuir 29:10498–10504PubMedCrossRefGoogle Scholar
  3. 3.
    Deng L, Ke X, He Z, Yang D, Gong H, Zhang Y, Jing X, Yao J, Chen J (2012) A MSLN-targeted multifunctional nanoimmunoliposome for MRI and targeting therapy in pancreatic cancer. Int J Nanomedicine 7:5053–5065PubMedPubMedCentralGoogle Scholar
  4. 4.
    Cho K, Wang X, Nie S, Chen ZG, Shin DM (2008) Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 14:1310–1316PubMedCrossRefGoogle Scholar
  5. 5.
    Ahmad MZ, Akhter S, Rahman Z, Akhter S, Anwar M, Mallik N, Ahmad FJ (2013) Nanometric gold in cancer nanotechnology: current status and future prospect. J Pharm Pharmacol 65:634–651PubMedCrossRefGoogle Scholar
  6. 6.
    Syed S, Zubair A, Frieri M (2013) Immune response to nanomaterials: implications for medicine and literature review. Curr Allergy Asthma Rep 13:50–57PubMedCrossRefGoogle Scholar
  7. 7.
    Zhang CY, Hu J (2010) Single quantum dot-based nanosensor for multiple DNA detection. Anal Chem 82:1921–1927PubMedCrossRefGoogle Scholar
  8. 8.
    Jokilaakso N, Salm E, Chen A, Millet L, Guevara CD, Dorvel B, Reddy B Jr, Karlstrom AE, Chen Y, Ji H et al (2013) Ultra-localized single cell electroporation using silicon nanowires. Lab Chip 13:336–339PubMedCrossRefGoogle Scholar
  9. 9.
    Barenholz Y (2012) Nanomedicine: shake up the drug containers. Nat Nanotechnol 7:483–484PubMedCrossRefGoogle Scholar
  10. 10.
    Zamboni WC, Torchilin V, Patri AK, Hrkach J, Stern S, Lee R, Nel A, Panaro NJ, Grodzinski P (2012) Best practices in cancer nanotechnology: perspective from NCI nanotechnology alliance. Clin Cancer Res 18:3229–3241PubMedCrossRefPubMedCentralGoogle Scholar
  11. 11.
    Zheng S, Li X, Zhang Y, Xie Q, Wong YS, Zheng W, Chen T (2012) PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction. Int J Nanomedicine 7:3939–3949PubMedPubMedCentralGoogle Scholar
  12. 12.
    Niikura K, Iyo N, Matsuo Y, Mitomo H, Ijiro K (2013) Sub-100 nm gold nanoparticle vesicles as a drug delivery carrier enabling rapid drug release upon light irradiation. ACS Appl Mater Interfaces 5:3900–3907PubMedCrossRefGoogle Scholar
  13. 13.
    Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y, Chen CT et al (2013) Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small 9:4123–4129PubMedCrossRefGoogle Scholar
  14. 14.
    Loch-Neckel G, Nemen D, Puhl AC, Fernandes D, Stimamiglio MA, Alvarez Silva M, Hangai M, Santos Silva MC, Lemos-Senna E (2007) Stealth and non-stealth nanocapsules containing camptothecin: in-vitro and in-vivo activity on B16-F10 melanoma. J Pharm Pharmacol 59:1359–1364PubMedCrossRefGoogle Scholar
  15. 15.
    Arany S, Xu Q, Hernady E, Benoit DS, Dewhurst S, Ovitt CE (2012) Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. J Cell Biochem 113:1955–1965PubMedCrossRefPubMedCentralGoogle Scholar
  16. 16.
    Im JS, Bai B, Lee YS (2010) The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system. Biomaterials 31:1414–1419PubMedCrossRefGoogle Scholar
  17. 17.
    Chakravarty P, Qian W, El-Sayed MA, Prausnitz MR (2010) Delivery of molecules into cells using carbon nanoparticles activated by femtosecond laser pulses. Nat Nanotechnol 5:607–611PubMedCrossRefPubMedCentralGoogle Scholar
  18. 18.
    Ali Khan A, Mudassir J, Mohtar N, Darwis Y (2013) Advanced drug delivery to the lymphatic system: lipid-based nanoformulations. Int J Nanomedicine 8:2733–2744PubMedGoogle Scholar
  19. 19.
    Gruber HE, Hoelscher GL, Ingram JA, Hanley EN Jr (2012) Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro. Exp Mol Pathol 92:59–63PubMedCrossRefGoogle Scholar
  20. 20.
    Matsudai M, Hunt G (2005) Nanotechnology and public health. Nihon koshu eisei zasshi 52:923–927PubMedGoogle Scholar
  21. 21.
    Bratschitsch R, Leitenstorfer A (2006) Quantum dots: artificial atoms for quantum optics. Nat Mater 5:855–856PubMedCrossRefGoogle Scholar
  22. 22.
    Biondi M, Guarnieri D, Yu H, Belli V, Netti PA (2013) Sub-100 nm biodegradable nanoparticles: in vitro release features and toxicity testing in 2D and 3D cell cultures. Nanotechnology 24:045101PubMedCrossRefGoogle Scholar
  23. 23.
    Mozafari MR, Johnson C, Hatziantoniou S, Demetzos C (2008) Nanoliposomes and their applications in food nanotechnology. J Liposome Res 18:309–327PubMedCrossRefGoogle Scholar
  24. 24.
    Li D, Yang K, Li JS, Ke XY, Duan Y, Du R, Song P, Yu KF, Ren W, Huang D et al (2012) Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings. Int J Nanomedicine 7:6105–6114PubMedPubMedCentralGoogle Scholar
  25. 25.
    Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A et al (2013) Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature 495:467–473PubMedCrossRefPubMedCentralGoogle Scholar
  26. 26.
    Ravichandran R, Venugopal JR, Mueller M, Sundarrajan S, Mukherjee S, Pliska D, Wintermantel E, Ramakrishna S (2013) Buckled structures and 5-azacytidine enhance cardiogenic differentiation of adipose-derived stem cells. Nanomedicine (Lond) 8:1985–1997CrossRefGoogle Scholar
  27. 27.
    Kruss S, Hilmer AJ, Zhang J, Reuel NF, Mu B, Strano MS (2013) Carbon nanotubes as optical biomedical sensors. Adv Drug Deliv Rev 65:1933–1950PubMedCrossRefGoogle Scholar
  28. 28.
    Viswanathan V, Wang FY (2012) Theoretical analysis of the effect of particle size and support on the kinetics of oxygen reduction reaction on platinum nanoparticles. Nanoscale 4:5110–5117PubMedCrossRefGoogle Scholar
  29. 29.
    Subramanian S, Singireddy A, Krishnamoorthy K, Rajappan M (2012) Nanosponges: a novel class of drug delivery system – review. J Phar Pharm Sci 15:103–111Google Scholar
  30. 30.
    Lu YJ, Yang HW, Hung SC, Huang CY, Li SM, Ma CC, Chen PY, Tsai HC, Wei KC, Chen JP (2012) Improving thermal stability and efficacy of BCNU in treating glioma cells using PAA-functionalized graphene oxide. Int J Nanomedicine 7:1737–1747PubMedPubMedCentralGoogle Scholar
  31. 31.
    Li Z, Wu X, Li J, Yao L, Sun L, Shi Y, Zhang W, Lin J, Liang D, Li Y (2012) Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model. Int J Nanomedicine 7:2389–2398PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Zavaleta CL, Garai E, Liu JT, Sensarn S, Mandella MJ, Van de Sompel D, Friedland S, Van Dam J, Contag CH, Gambhir SS (2013) A Raman-based endoscopic strategy for multiplexed molecular imaging. Proc Natl Acad Sci U S A 110:E2288–E2297PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Tobin LA, Xie Y, Tsokos M, Chung SI, Merz AA, Arnold MA, Li G, Malech HL, Kwong KF (2013) Pegylated siRNA-loaded calcium phosphate nanoparticle-driven amplification of cancer cell internalization in vivo. Biomaterials 34:2980–2990PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Chiang PC, Deng Y, Ubhayaka S, La H, Cui Y, Chou KJ, Ran Y, Wong H (2012) Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications. J Nanosci Nanotechnol 12:7993–8000PubMedCrossRefGoogle Scholar
  35. 35.
    Lathrop JT, Hayes TK, Carrick K, Hammond DJ (2005) Rarity gives a charm: evaluation of trace proteins in plasma and serum. Expert Rev Proteomics 2:393–406PubMedCrossRefGoogle Scholar
  36. 36.
    Worsley GJ, Attree SL, Noble JE, Horgan AM (2012) Rapid duplex immunoassay for wound biomarkers at the point-of-care. Biosens Bioelectron 34:215–220PubMedCrossRefGoogle Scholar
  37. 37.
    Merenbloom BK, Oberhardt BJ (1995) Homogeneous immunoassay of whole-blood samples. Clin Chem 41:1385–1390PubMedGoogle Scholar
  38. 38.
    Bokenkamp A, Franke I, Schlieber M, Duker G, Schmitt J, Buderus S, Lentze MJ, Stoffel-Wagner B (2007) Beta-trace protein–a marker of kidney function in children: “original research communication-clinical investigation”. Clin Biochem 40:969–975PubMedCrossRefGoogle Scholar
  39. 39.
    Kristensen K, Wide-Swensson D, Schmidt C, Blirup-Jensen S, Lindstrom V, Strevens H, Grubb A (2007) Cystatin C, beta-2-microglobulin and beta-trace protein in pre-eclampsia. Acta Obstet Gynecol Scand 86:921–926PubMedCrossRefGoogle Scholar
  40. 40.
    Luchini A, Fredolini C, Espina BH, Meani F, Reeder A, Rucker S, Petricoin EF 3rd, Liotta LA (2010) Nanoparticle technology: addressing the fundamental roadblocks to protein biomarker discovery. Curr Mol Med 10:133–141PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Luk BT, Fang RH, Zhang L (2012) Lipid- and polymer-based nanostructures for cancer theranostics. Theranostics 2:1117–1126PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Chan CP, Mak WC, Cheung KY, Sin KK, Yu CM, Rainer TH, Renneberg R (2013) Evidence-based point-of-care diagnostics: current status and emerging technologies. Annu Rev Anal Chem 6:191–211CrossRefGoogle Scholar
  43. 43.
    Tripp RA, Alvarez R, Anderson B, Jones L, Weeks C, Chen W (2007) Bioconjugated nanoparticle detection of respiratory syncytial virus infection. Int J Nanomedicine 2:117–124PubMedCrossRefPubMedCentralGoogle Scholar
  44. 44.
    Sonnenberg A, Marciniak JY, Krishnan R, Heller MJ (2012) Dielectrophoretic isolation of DNA and nanoparticles from blood. Electrophoresis 33:2482–2490PubMedCrossRefGoogle Scholar
  45. 45.
    Yeo WH, Chung JH, Liu Y, Lee KH (2009) Size-specific concentration of DNA to a nanostructured tip using dielectrophoresis and capillary action. J Phys Chem B 113:10849–10858PubMedCrossRefGoogle Scholar
  46. 46.
    Thiollet S, Higson S, White N, Morgan SL (2012) Investigation and development of quantum dot-encoded microsphere bioconjugates for DNA detection by flow cytometry. J Fluoresc 22:685–697PubMedCrossRefGoogle Scholar
  47. 47.
    Bunzli J-CG, Piguet C (2005) Taking advantage of luminescent lanthanide ions. Chem Soc Rev 34:1048–1077PubMedCrossRefGoogle Scholar
  48. 48.
    Richardson FS (1982) Terbium(III) and europium(III) ions as luminescent probes and stains for biomolecular systems. Chem Rev 82:541–552CrossRefGoogle Scholar
  49. 49.
    Sabbatini N, Guardigli M, Manet I, Ungaro R, Casnati A, Ziessel R, Ulrich G, Asfari Z, Lehnd J-M (1995) Lanthanide complexes of encapsulating ligands: luminescent devices at the molecular level. Pure Appl Chem 67:135–140CrossRefGoogle Scholar
  50. 50.
    Tang S, Moayeri M, Chen Z, Harma H, Zhao J, Hu H, Purcell RB, Leppla S, Hewlett IK (2009) Detection of anthrax toxin by an ultrasensitive immunoassay using Europium nanoparticles. Clin Vaccine Immunol 16:408–413PubMedCrossRefPubMedCentralGoogle Scholar
  51. 51.
    Wahl R (2006) Star trek meets the operating room: nurse scotty, beam me up-A tricorder. Ann Surg Oncol: 2Google Scholar
  52. 52.
    Davies P (2001) The origin of life. I: when and where did it begin? Sci Prog 84:1–16PubMedCrossRefGoogle Scholar
  53. 53.
    Buckey JC Jr (1999) Preparing for Mars: the physiologic and medical challenges. Eur J Med Res 4:353–356PubMedGoogle Scholar
  54. 54.
    Waters H (2011) New $10 million X prize launched for tricorder-style medical device. Nat Med 17:754Google Scholar
  55. 55.
    McKenna P (2013) The quest to put a doctor in your pocket. New Sci 218:46–49CrossRefGoogle Scholar
  56. 56.
    Zanni GR (2013) Medical apps worth having. Consult Pharm 28:322–324PubMedCrossRefGoogle Scholar
  57. 57.
    Boyd AD, Naiman M, Stevenson GW, Preston R, Valenta AL (2013) Technical and operational users’ opinions of a handheld device to detect directed energy. Aviat Space Environ Med 84:528–533PubMedCrossRefGoogle Scholar
  58. 58.
    Kwon JT, Hwang SK, Jin H, Kim DS, Minai-Tehrani A, Yoon HJ, Choi M, Yoon TJ, Han DY, Kang YW et al (2008) Body distribution of inhaled fluorescent magnetic nanoparticles in the mice. J Occup Health 50:1–6PubMedCrossRefGoogle Scholar
  59. 59.
    Antunes AM, Alencar MS, da Silva CH, Nunes J, Mendes FM (2012) Trends in nanotechnology patents applied to the health sector. Recent Pat Nanotechnol 6:29–43PubMedCrossRefGoogle Scholar
  60. 60.
    Demetzos C, Pippa N (2013) Advanced drug delivery nanosystems (aDDnSs): a mini-review. Drug Deliv 21:250–257Google Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  • Thomas Tumillo
    • 1
  • Avijit Roy
    • 1
  • Sahana Pentyala
    • 1
  • Pooja Mysore
    • 1
  • Srinivas N. Pentyala
    • 1
  1. 1.Department of AnesthesiologyStony Brook Medical CenterNew YorkUSA

Personalised recommendations