Inhaled Nitric Oxide Therapy for Treatment of High-Altitude Pulmonary Edema

  • G. Himashree
  • R. K. Gupta
  • B. A. K. Prasad
  • Shashi Bala Singh


High-altitude pulmonary edema (HAPE) is a severe form of acute mountain sickness. It may be fatal if not diagnosed well in time. Treatment includes descent to low altitude, supplemental oxygen, and calcium channel blocker. Endogenous production of nitric oxide in the lungs has been found to be reduced in individuals susceptible to HAPE. Administration of inhaled nitric oxide and oxygen combination has been found to be more effective in improving tissue oxygenation than giving oxygen or nifedipine. Additional benefits are less toxicity and rapid action due to inhalation mode of therapy. Commercially available inhaled nitric oxide delivery systems are ventilator-based, designed for patients of respiratory failure who require ventilatory support. However, HAPE patients breathe spontaneously and do not require ventilatory support. Hence there was a need for an indigenous NO delivery system tailor-made for HAPE patients. Two prototypes have been developed and currently undergoing clinical trials.


Nitric Oxide Pulmonary Hypertension Pulmonary Artery Pressure Pulmonary Blood Flow Acute Mountain Sickness 
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Copyright information

© Springer India 2014

Authors and Affiliations

  • G. Himashree
    • 1
  • R. K. Gupta
    • 1
  • B. A. K. Prasad
    • 1
  • Shashi Bala Singh
    • 2
  1. 1.High Altitude Physiology GroupDefence Institute of Physiology and Allied Sciences (DIPAS)Timarpur, DelhiIndia
  2. 2.Defence Institute of Physiology and Allied Sciences (DIPAS)New DelhiIndia

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