Antioxidant Drugs Mitigating Toxicity

  • Shabnum Nabi


An antioxidant is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons or hydrogen from a substance to an oxidizing agent. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions. When the chain reaction occurs in a cell, it can cause damage or death to the cell. Antioxidants terminate these chain reactions by removing free radical intermediates and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are often reducing agents such as thiols, ascorbic acid, or polyphenols (Sies 1997).


Fatty Acid Oxidation Lipoic Acid Organic Mercury Nonenzymatic Antioxidant Free Radical Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Ando S, Tadenuma T, Tanaka Y, Fukui F, Kobayashi S, Ohashi Y, Kawabata T (2001) Enhancement of learning capacity and cholinergic synaptic function by carnitine in ageing rats. J Neurosci Res 66:266–271PubMedCrossRefGoogle Scholar
  2. Arockia Rani PJ, Panneerselvam C (2001) Carnitine as a free radical scavenger in ageing. Exp Gerontol 36:1713–1726PubMedCrossRefGoogle Scholar
  3. Baillie JK, Thompson AAR, Irving JB, Bates MGD, Sutherland AI, MacNee W, Maxwell SRJ, Webb DJ (2009) Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial. QJM 102(5):341–348PubMedCrossRefGoogle Scholar
  4. Benvenga S, Ruggeri RM, Russo A, Lapa D, Capanni A, Trimarchi F (2001) Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Endocrinol Metab 86:3579–3594CrossRefGoogle Scholar
  5. Bertoni-Freddari C, Fattoretti P, Caselli U, Paoloni R (1996) Acetyl carnitine modulation of the morphology of rat hippocampal synapses. Anal Quant Cytol Histol 18:275–278PubMedGoogle Scholar
  6. Bigini P, Larini S, Pasquali C, Muzio V, Mennini T (2002) Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons. Neurosci Lett 329:334–338PubMedCrossRefGoogle Scholar
  7. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297(8):842–857PubMedCrossRefGoogle Scholar
  8. Brass EP (2000) Supplemental carnitine and exercise. Am J Clin Nutr 72:618S–623SPubMedGoogle Scholar
  9. Brass EP, Hiatt WR (1998) The role of carnitine and carnitine supplementation during exercise in man and in individuals with special needs. J Am Coll Nutr 17:207–215PubMedCrossRefGoogle Scholar
  10. Calvani M, Arrigoni-Martelli E (1999) Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and repurfusion. Int J Tissue React 21:1–6PubMedGoogle Scholar
  11. Dabelstein W, Reglitzky A, Schütze A, Reders K (2007) Automotive fuels. In: Ullmann’s encyclopedia of industrial chemistry. Wiley-VCH Verlag GmbH & Co. KGaAGoogle Scholar
  12. De Angelis C, Scarfo C, Falcinelli M, Perna E, Reda E, Ramacci MT, Angelucci L (1994) Acetyl-L-Carnitine prevents age-dependent structural alterations in rat peripheral nerves and promotes regeneration following sciatic nerve injury in young and senescent rats. Exp Neurol 28:103–114CrossRefGoogle Scholar
  13. Ghidino O, Azzurro M, Vita G, Sartori G (1988) Evaluation of the therapeutic efficacy of L-Carnitine in congestive heart failure. Int J Clin Pharmacol Ther Toxicol 26:217–220Google Scholar
  14. Hart AM, Wiberg M, Youle M, Terenghi G (2002) Systemic acetyl-L-carnitine eliminates sensory neuronal loss after peripheral axotomy: a new clinical approach in the management of peripheral nerve trauma. Exp Brain Res 145:182–189PubMedCrossRefGoogle Scholar
  15. Iossa S, Mollica MP, Lionett IL, Crescenzo R, Botta M, Barletta A, Liverini G (2002) Acetyl L-Carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial in young and old rats. J Nutr 132:636–642PubMedGoogle Scholar
  16. Ishii T, Shimpo Y, Matsuoka Y, Kinoshita K (2000) Anti-apoptotic effect of acetyl-L- carnitine and I-carnitine in primary cultured neurons. Jpn J Pharmacol 83:119–124PubMedCrossRefGoogle Scholar
  17. Jha P, Flather M, Lonn E, Farkouh M, Yusuf S (1995) The antioxidant vitamins and cardiovascular disease: a critical review of epidemiologic and clinical trial data. Ann Intern Med 123(11):860–872PubMedCrossRefGoogle Scholar
  18. Liu J, Killilea DW, Ames BN (2002a) Age associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci 99:1876–1881PubMedCentralPubMedCrossRefGoogle Scholar
  19. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN (2002b) Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci 99:2356–2361PubMedCentralPubMedCrossRefGoogle Scholar
  20. Mckay Hart A, Wiberg M, Terenghi G (2002) Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment. Neurosci Lett 334:181–185PubMedCrossRefGoogle Scholar
  21. Muller DM, Seim H, Kiess W, Loster H, Richter T (2002) Effects of oral L-Carnitine supplementation on in vivo long chain fatty acid oxidation in healthy adults. Metabolism 51:1389–1391PubMedCrossRefGoogle Scholar
  22. Rani PJ, Panneerselvam C (2002) Effect of L-Carnitine on brain lipid peroxidation and antioxidant enzymes in old rats. J Gerontol A Biol Sci Med Sci 57:B134–B137PubMedCrossRefGoogle Scholar
  23. Reznick AZ, Kagan VE, Ramsey R, Tsuchiya M, Khwaja S, Serbinova EA, Packer L (1992) Antiradionyl effect of L-propionyl Carnitine protection of the heart against ischemia- repurfusion injury: the possible role of iron chelation. Arch Biochem Biophys 296:394–401PubMedCrossRefGoogle Scholar
  24. Salvioli G, Neri M (1994) L-acetyl carnitine treatment of mental decline in the elderly. Drugs Exp Clin Res 20:169–176PubMedGoogle Scholar
  25. Sies H (1997) Oxidative stress: oxidants and antioxidants. Exp Physiol 82(2):291–295PubMedGoogle Scholar
  26. Taglialatela G, Angelucci L, Ramacci MT, Werrbach-Perez K, Jackson GR, Perez-polo JR (1992) Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. Biochem Pharmacol 44:577–585PubMedCrossRefGoogle Scholar
  27. Toth E, Harsing LG, Sershen H, Ramacci MT, Lajtha A (1993) Effect of acetyl-L-carnitine on extracellular amino acid levels in vivo in rat brain regions. Neurochem Res 18:573–578PubMedCrossRefGoogle Scholar
  28. Vanella A, Russo A, Acquaviva R, Campisi A, Di Giacomo C, Sorrenti V, Barcellona ML (2000) L-Propionyl-carnitine as superoxide scavenger, antioxidant and DNA cleavage protector. Cell Biol Toxicol 16:99–104PubMedCrossRefGoogle Scholar
  29. Virmani MA, Biselli R, Spadoni A, Rossi S, Corsico N, Calvani M, Fattorossi A, De Simone C, Arrigoni-Martelli E (1995) Protective actions of L-Carnitine and Acetyl-L-Carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors. Pharmacol Res 32:383–389PubMedCrossRefGoogle Scholar
  30. Yasui F, Matsugo S, Ishibashi M, Kajita T, Ezashi Y, Oomura Y, Kojo S, Sasaki K (2002) Effects of chronic acetyl-l-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learningin senescence-accelerated mice. Neurosci Lett 334:177–180Google Scholar

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© Springer India 2014

Authors and Affiliations

  • Shabnum Nabi
    • 1
  1. 1.Interdisciplinary Brain Research Centre (IBRC) Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia

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