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Methylmercury and Amyotrophic Lateral Sclerosis

  • Shabnum Nabi
Chapter

Abstract

ALS is a systemic motor neuron disease that affects the corticospinal and corticobulbar tracts, ventral horn motor neurons, and motor cranial nerve nuclei. Approximately 10 % of ALS cases are of the familial type that has been linked to a mutation of the copper/zinc superoxide dismutase gene (Cu/Zn SOD). The majority of ALS cases are of the sporadic type. Based on studies of groups of monozygous twins, animal studies, and ALS patient case studies, the majority of ALS cases does not appear to be genetic but rather have primarily environmental-related causes often affecting genetically susceptible individual. Mutation of the FUS gene or TPD-43 gene has been shown to be one of the major factors in familial and some sporadic ALS.

Keywords

Amyotrophic Lateral Sclerosis Motor Neuron Lyme Disease Amyotrophic Lateral Sclerosis Patient Lipoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer India 2014

Authors and Affiliations

  • Shabnum Nabi
    • 1
  1. 1.Interdisciplinary Brain Research Centre (IBRC) Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia

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