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Toxic Responses of the Plasma Xanthine Oxidase (XO)

  • Shabnum Nabi
Chapter

Abstract

Xanthine oxidase is an important source of free oxygen radicals, especially superoxide anions, because it is able to use molecular oxygen instead of NAD+ as electron acceptor in the two-step conversion of hypoxanthine to uric acid. This reaction mechanism has been confirmed in both animal and human studies (Connors et al. 1981; Brown et al. 1988; Ferreira et al. 1988; Pietz et al. 1988) and is probably the primary source of reactive oxygen species after reperfusion of ischemic tissues (Saugstad and Aasen 1980).

Keywords

Uric Acid Xanthine Oxidase Adult Respiratory Distress Syndrome Xanthine Oxidase Activity Xanthine Dehydrogenase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer India 2014

Authors and Affiliations

  • Shabnum Nabi
    • 1
  1. 1.Interdisciplinary Brain Research Centre (IBRC) Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia

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