Deregulation of Antioxidant Activities
Methylmercury is one of the most toxic forms of Hg exerting its major toxic effects on the central nervous system (Clarkson et al. 2003). Several mechanisms by which Hg exerts its adverse effects have been hypothesized in acute exposure to high levels; among them, impairment of intracellular calcium homeostasis (Aschner et al. 2007; Dietrich et al. 2005; Sirois and Atchison 2000) and alteration of glutamate homeostasis (Aschner et al. 2000) were reported. However, it is believed that the major process responsible for triggering the toxicity is the oxidative stress.
KeywordsSpinal Cord Brain Stem Tail Suspension Test Intracellular Calcium Homeostasis Glutamate Homeostasis
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