Deregulation of Antioxidant Activities

  • Shabnum Nabi


Methylmercury is one of the most toxic forms of Hg exerting its major toxic effects on the central nervous system (Clarkson et al. 2003). Several mechanisms by which Hg exerts its adverse effects have been hypothesized in acute exposure to high levels; among them, impairment of intracellular calcium homeostasis (Aschner et al. 2007; Dietrich et al. 2005; Sirois and Atchison 2000) and alteration of glutamate homeostasis (Aschner et al. 2000) were reported. However, it is believed that the major process responsible for triggering the toxicity is the oxidative stress.


Spinal Cord Brain Stem Tail Suspension Test Intracellular Calcium Homeostasis Glutamate Homeostasis 
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  1. Abdel-Hamid HA, Fahmy FC, Sharaf IA (2001) Influence of free radicals on cardiovascular risk due to occupational exposure to mercury. J Egypt Public Health Assoc 76:53–69PubMedGoogle Scholar
  2. Amin-Zaki L, Majeed MA, Elhassani SB, Clarkson TW, Greenwood MR, Doherty RA (1979) Prenatal methylmercury poisoning: clinical observations over five years. Am J Dis Child 133:172–177PubMedCrossRefGoogle Scholar
  3. Ariza ME, Bijur GN, Williams MV (1998) Lead and mercury metagenesis: role of H2O2, superoxide dismutase, and xanthine oxidase. Environ Mol Mutagen 31:352–361PubMedCrossRefGoogle Scholar
  4. Aschner M, Yao CP, Allen JW, Tan KH (2000) Methylmercury alters glutamate transport in astrocytes. Neurochem Int 37:188–206CrossRefGoogle Scholar
  5. Aschner M, Syversen T, Souza DO, Rocha JBT, Farina M (2007) Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res 40:285–291PubMedCrossRefGoogle Scholar
  6. Bukowska B (2004) 2, 4, 5-T and 2, 4, 5-TCP induces oxidative damage in human erythrocytes: the role of glutathione. Cell Biol Int 28:557–563PubMedCrossRefGoogle Scholar
  7. Burbacher TM, Rodier PM, Weiss B (1990) Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals. Neurotoxicol Teratol 12:191–202PubMedCrossRefGoogle Scholar
  8. Clarkson TW, Magos L, Myers GJ (2003) The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med 349:1731–1737PubMedCrossRefGoogle Scholar
  9. Debes F, Budtz-Jorgensen E, Weihe P, White RF, Grandjean P (2006) Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol 28:363–375PubMedCentralPubMedCrossRefGoogle Scholar
  10. Dietrich MO, Mantese CE, Anjos GD, Souza DO, Farina M (2005) Motor impairment induced by oral exposure to methylmercury in adult mice. Environ Toxicol Pharmacol 19:169–175PubMedCrossRefGoogle Scholar
  11. Duchen MR (2000) Mitochondria and Ca (2+) in cell physiology and pathophysiology. Cell Calcium 28:339–348PubMedCrossRefGoogle Scholar
  12. Dutczak WJ, Ballatori N (1994) Transport of the glutathione–methylmercury complex across liver canalicular membranes on reduced glutathione carriers. J Biol Chem 269:9746–9751PubMedGoogle Scholar
  13. Freeman BA, Crapo JD (1982) Biology of disease-free radicals and tissue injury. Lab Investig 47:412–426PubMedGoogle Scholar
  14. Gilbert SG, Grant-Webster KS (1995) Neurobehavioral effects of developmental methylmercury exposure. Environ Health Perspect 103:135–142PubMedCentralPubMedCrossRefGoogle Scholar
  15. Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PL (1997) Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19:417–428PubMedCrossRefGoogle Scholar
  16. Halliwell B, Chirico S (1993) Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 57:715–725Google Scholar
  17. Harada M (1995) Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol 25:1–24PubMedCrossRefGoogle Scholar
  18. Husain K, Dube SN, Sugenolran K, Singh R, Das Gupta S, Somani SM (1996) Effect of topically applied sulphur mustard on antioxidant enzymes in blood cells and body tissues of rat. J Appl Toxicol 16:245–248PubMedCrossRefGoogle Scholar
  19. Hussain S, Atkinson A, Thompson SJ, Khan AT (1999) Accumulation of mercury and its effect on antioxidant enzymes in brain, liver, and kidneys of mice. J Environ Sci Health B 34:645–660PubMedCrossRefGoogle Scholar
  20. Kono Y, Fridovich I (1982) Superoxide radical inhibits catalase. J Biol Chem 257:5751–5754PubMedGoogle Scholar
  21. Li Y, Yan XP, Chen C, Xia YL, Jiang Y (2007) Human serum albumin–mercurial species interactions. J Proteome Res 6:2277–2286PubMedCrossRefGoogle Scholar
  22. Meister A (1983) Selective modification of glutathione metabolism. Science 220:472–477PubMedCrossRefGoogle Scholar
  23. Rabenstein DL, Fairhurst MT (1975) Nuclear magnetic resonance studies of the solution chemistry of metal complexes XI: binding of methylmercury by sulfhydryl-containing amino acids and by glutathione. J Am Chem Soc 97:2086–2092PubMedCrossRefGoogle Scholar
  24. Refsvik T (1978) Excretion of methyl mercury in rat bile: the effect of diethylmaleate, cyclohexene oxide and acrylamide. Acta Pharmacol Toxicol 42:135–141CrossRefGoogle Scholar
  25. Sirois JE, Atchison WD (2000) Methylmercury affects multiple subtypes of calcium channels in rat cerebellar granule cells. Toxicol Appl Pharmacol 167:1–11PubMedCrossRefGoogle Scholar
  26. Sood PP, Bapu C, Sinha N, Rao AP (1997) Cholesterol and triglyceride fluctuations in mice tissues during methylmercury intoxication and monothiols and vitamin therapy. J Nutr Environ Med 7:155–162CrossRefGoogle Scholar
  27. Stringari J, Meotti FC, Souza DO, Santos ARS, Farina M (2006) Postnatal methylmercury exposure induces hyperlocomotor activity and cerebellar oxidative stress in mice: dependence on the neurodevelopmental period. Neurochem Res 31:563–569PubMedCrossRefGoogle Scholar
  28. Thompson SA, White CC, Krejsa CM, Eaton DL, Kavanagh TJ (2000) Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development. Toxicol Sci 57:141–146PubMedCrossRefGoogle Scholar

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© Springer India 2014

Authors and Affiliations

  • Shabnum Nabi
    • 1
  1. 1.Interdisciplinary Brain Research Centre (IBRC) Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia

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