Abstract
Smooth muscle tumors of uncertain malignant potential or otherwise known as the “STUMP” is a rare group of smooth muscle tumors intermediate between leiomyomas and leiomyosarcomas (LMS) [1] . The term “STUMP” was first used by Kempson in 1973 [2]. It was the work of Taylor and Norris which established the importance of mitotic figures in evaluating smooth muscle tumors of the uterus a half century ago [2], but it soon became evident that some uterine smooth muscle neoplasms with relatively low mitotic indices (5–10 mitotic figures [mf] per 10 high-power fields [hpf]) were capable of behaving in a clinically aggressive manner and that not all tumors with a mitotic index greater than 10 mf/10 hpf were clinically malignant. The term smooth muscle tumor of uncertain malignant potential was created for the 5–9 mitotic index group to reflect the uncertainty about the true failure rate in this group [3–7]. WHO defines STUMP as a smooth muscle tumor that cannot be diagnosed reliably as benign or malignant on the basis of generally applied criteria [8].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Deodhar KK, Goyal P, Rekhi B, et al. Uterine smooth muscle tumors of uncertain malignant potential and atypical leiomyoma: a morphological study of these grey zones with clinical correlation. Indian J Pathol Microbiol. 2011;54:706–11.
Kempson RL. Sarcomas and related neoplasms. In: Noris HJ, Hertig AT, Abel MR, editors. The uterus. Baltimore: Williams and Wilkins; 1973.
Bell SW, Kempson RL, Hendrickeson MR. Problematic uterine smooth muscleneoplasms: a clinicopathological study of 213cases. Am J Surg Pathol. 1994;18:535–58.
Kempson R, Bari W. Uterine sarcomas: classification diagnosis and prognosis. Hum Pathol. 1970;1:331–49.
O’Connor D, Norris H. Mitotically active leiomyoma of the uterus. Hum Pathol. 1990;21:223–7.
Perrone T, Dehner L. Prognostically favorable mitotically active smooth muscle tumors of the uterus. Am J Surg Pathol. 1988;12:1–8. PubMed | ISI | ChemPort.
Prayson RA, Hart WR. Mitotically active leiomyomas of the uterus. Am J Clin Pathol. 1992;97:14–20.
Tavassoli FA, Devilee P, editors. Chapter 4: Tumours of the uterine corpus. In Pathology and genetics of tumours of the breast and female genital organs: World Health Organization classification of tumors. Geneva: WHO press; 2012.
Ng JSY, Han A, Chew SH, Low J. A clinicopathologic study of uterine smooth muscle tumours of uncertain malignant potential (STUMP). Ann Acad Med Singapore. 2010;39:625–8.
Tanaka YO, Nishida M, Tsunoda H, et al. Smooth muscle tumors of uncertain malignant potential and leiomyosarcomas of the uterus: MR findings. J Magn Reson Imaging. 2004;20(6):998–1007.
Mayerhofer K, Lozanov P, Bodner K, Bodner-Adler B, Kimberger O, Czerwenka K, et al. Ki-67 expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS). Acta Obstet Gynecol Scand. 2004;83:1085–8.
Ip PP, Cheung AN, Clement PB. Uterine smooth muscle tumors of uncertain malignant potential (stump): a clinicopathologic analysis of 16 case. Am J Surg Pathol. 2009;33:992–1005.
Odunsi K, Pejovic T. Gynecological cancers multidisciplinary approach to diagnosis and treatment of uterine sarcoma. New York: Demos Publishing Company; 2013. p. 83–93.
Guntupalli SR, Ramirez PT, Anderson ML, Milam MR, Bodurka DC, Malpica A. Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis. Gynecol Oncol. 2009;113(3):324–6.
Kotsupoulos IC, Barbetakis N, Asteriou C, et al. Uterine smooth muscle tumor of uncertain malignant potential: a rare cause of multiple pulmonary nodules. Indian J Med Paediat Oncol. 2012;33(3):176–8.
Shapiro A, Ferenczy A, Turcotte R, Bruchim I, Gotlieb WH. Uterine smooth-muscle tumor of uncertain malignant potential metastasizing to the humerus as a high-grade leiomyosarcoma. Gynecol Oncol. 2004;94(3):818–20.
Philip PC, Tse KY, Tam KF. Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol. 2010;17(2):91–111.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer India
About this chapter
Cite this chapter
Sreedharan, N., Chitrathara, K. (2015). Smooth Muscle Tumors of Uncertain Malignant Potential of Uterine Origin. In: Rajaram, S., K, C., Maheshwari, A. (eds) Uterine Cancer. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1892-0_38
Download citation
DOI: https://doi.org/10.1007/978-81-322-1892-0_38
Publisher Name: Springer, New Delhi
Print ISBN: 978-81-322-1891-3
Online ISBN: 978-81-322-1892-0
eBook Packages: MedicineMedicine (R0)