Uterine Cancer pp 397-403 | Cite as

Management of Incompletely Staged Endometrial Cancer

  • Shalini Rajaram
  • Neha Kumar


In clinical practice, we often come across cases where endometrial carcinoma has been detected postoperatively on a hysterectomy specimen. These cases where only hysterectomy and bilateral salpingo-oophorectomy have been done, especially those with high-risk intrauterine features are incompletely staged and require appropriate management.


Endometrial Cancer National Comprehensive Cancer Network Endometrial Carcinoma National Comprehensive Cancer Network Surgical Staging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Creasman WT, Odicino F, Maisonneuve P, et al. Carcinoma of the corpus uteri. FIGO 26th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006;95:105–43.CrossRefGoogle Scholar
  2. 2.
    Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group study. Cancer. 1987;60:2035–41.CrossRefPubMedGoogle Scholar
  3. 3.
    Morrow CP, Bundy BN, Kurman RJ, et al. Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol. 1991;40:55–65.CrossRefPubMedGoogle Scholar
  4. 4.
    Koh WJ, Greer BE, Abu-Rustum NR, et al. Uterine neoplasms, version 1.2014. J Natl Compr Canc Netw. 2014;12:248–80.PubMedGoogle Scholar
  5. 5.
    Mariani A, Dowdy SC, Cliby WA, et al. Efficacy of systematic lymphadenectomy and adjuvant radiotherapy in node-positive endometrial cancer women. Gynecol Oncol. 2006;101:200–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Kilgore LC, Partridge EE, Alvarez RD, et al. Adenocarcinoma of the endometrium: survival comparison of women with and without pelvic node sampling. Gynecol Oncol. 1995;56:29–33.CrossRefPubMedGoogle Scholar
  7. 7.
    Havrilesky LJ, Cragun JM, Calingaert B, et al. Resection of lymph node metastases influences survival in stage III endometrial cancer. Gynecol Oncol. 2005;99:689–95.CrossRefPubMedGoogle Scholar
  8. 8.
    Todo Y, Kato H, Kaneuchi M, et al. Survival effect of para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis. Lancet. 2010;375:1165–72.CrossRefPubMedGoogle Scholar
  9. 9.
    Creutzberg CL, van Putten WL, Koper PC, et al. Surgery and postoperative radiotherapy versus surgery alone for women with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group post-operative radiation therapy in endometrial carcinoma. Lancet. 2000;355:1404–11.CrossRefPubMedGoogle Scholar
  10. 10.
    ASTEC Study Group, Kitchener H, Swart AM, Qian Q, Amos C, Parmar MK. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet. 2009;373:125–36.CrossRefGoogle Scholar
  11. 11.
    Benedetti Panici P, Basile S, Maneschi F, et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst. 2008;100:1707–16.CrossRefPubMedGoogle Scholar
  12. 12.
    Ben-Shachar I, Pavelka J, Cohn DE, et al. Surgical staging for women presenting with grade 1 endometrial carcinoma. Obstet Gynecol. 2005;105:487–93.CrossRefPubMedGoogle Scholar
  13. 13.
    Goff BA, Rice LW. Assessment of depth of myometrial invasion in endometrial adenocarcinoma. Gynecol Oncol. 1990;38:46–8.CrossRefPubMedGoogle Scholar
  14. 14.
    Case AS, Rocconi RP, Straughn Jr JM, et al. A prospective blinded evaluation of the accuracy of frozen section for the surgical management of endometrial cancer. Obstet Gynecol. 2006;108:1375–9.CrossRefPubMedGoogle Scholar
  15. 15.
    Mariani A, Webb MJ, Keeney GL, Haddock MG, Calori G, Podratz KC. Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol. 2000;182:1506–19.CrossRefPubMedGoogle Scholar
  16. 16.
    Mariani A, Dowdy SC, Cliby WA, et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol Oncol. 2008;109:11–8.PubMedCentralCrossRefPubMedGoogle Scholar
  17. 17.
    Keys HM, Roberts JA, Brunetto VL, et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;92:744–51.CrossRefPubMedGoogle Scholar
  18. 18.
    ASTEC/EN.5 Study Group, Blake P, Swart AM, Orton J, et al. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis. Lancet. 2009;373:137–46.CrossRefGoogle Scholar
  19. 19.
    Sharma C, Deutsch I, Lewin SN, et al. Lymphadenectomy influences the utilization of adjuvant radiation treatment for endometrial cancer. Am J Obstet Gynecol. 2011;205:562.CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyUniversity College of Medical Sciences and Guru Teg Bahadur HospitalDelhiIndia
  2. 2.Department of Gynecologic OncologyTata Memorial HospitalMumbaiIndia

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