Uterine Cancer pp 293-305 | Cite as

Diagnosis and Management of Stage II Endometrial Cancer

  • Rebecca A. Previs
  • Diane C. Bodurka


Current staging guidelines define stage II endometrial carcinoma as a tumor that invades the cervical stroma but does not extend beyond the uterus. If the patient is deemed medically operable, surgical management remains the primary treatment modality with the goal of removing all gross disease. Pathologic evaluation of the surgical specimen can help tailor adjuvant chemotherapy. Previously, adjuvant radiation was a mainstay of treatment, but controversies exist about this modality given the lack of data to support improved overall survival. High-risk histologic subtypes (serous, clear cell, carcinosarcoma, high-grade endometrial sarcoma, and leiomyosarcoma) should receive adjuvant chemotherapy with or without tumor-directed radiation.


Endometrial Cancer National Comprehensive Cancer Network Endometrial Carcinoma National Comprehensive Cancer Network Radical Hysterectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Department of Gynecologic OncologyMD Anderson Cancer CentreHoustonUSA
  2. 2.Department of Gynecologic Oncology and Reproductive MedicineThe University of Texas MD Anderson Cancer CentreHoustonUSA
  3. 3.Department of Medical EducationThe University of Texas MD Anderson Cancer CentreHoustonUSA

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