Uterine Cancer pp 283-292 | Cite as

Chemotherapy for High-Risk Early-Stage Endometrial Cancer: Current Evidence

  • Seema Gulia
  • Sudeep Gupta


Endometrial cancer (EC) is the third common gynecological cancer affecting women in the Western world. By contrast, the incidence in developing countries is approximately tenfold lower [1]. The incidence in India is 2.3 per 100,000 women. Around 80 % of patients are diagnosed in early stages (FIGO stages I and II) and have good prognosis (5-year survival ~90 %). Currently patients with early-stage endometrial cancer are treated with primary surgery, which includes hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic node dissection with or without omentectomy. The histopathological information obtained from the pathology specimen is used to identify patients with adverse prognostic features who may benefit from adjuvant therapy. Several factors have been associated with the risk of recurrence including older age, higher grade, histologic type (i.e., serous or clear cell type), deep myometrial invasion, lymphovascular space invasion (LVSI), involvement of the cervical stroma, and large tumor size (>2 cm) [2–4]. The indication of adjuvant chemotherapy or radiotherapy is based on the aggregate risk conferred by these factors.


Overall Survival Endometrial Cancer Myometrial Invasion Deep Myometrial Invasion Locoregional Recurrence Rate 


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Copyright information

© Springer India 2015

Authors and Affiliations

  • Seema Gulia
    • 1
  • Sudeep Gupta
    • 1
  1. 1.Department of Medical OncologyTata Memorial CentreMumbaiIndia

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