Pathology of Endometrial Hyperplasia and Carcinoma
Endometrial cancer forms the fifth most commonly diagnosed cancer in women worldwide and the fourth most commonly diagnosed cancer in the United States [1, 2]. On an average, 154 cases are annually received at Tata Memorial Hospital (TMH), as per TMH Based Cancer Registry (2002–2005) . These occur mostly in postmenopausal women. This chapter shall focus upon pathology of endometrial hyperplasias and carcinomas, including various subtypes; diagnostic challenges involved during histopathological reporting; overcoming these challenges; insights into relevant immunohistochemistry; molecular updates and finally, formulation of a scientifically correct and clinically relevant/viable histopathology report, including diagnosis.
KeywordsLynch Syndrome Endometrial Carcinoma Myometrial Invasion Endometrial Hyperplasia Endometrial Adenocarcinoma
I am grateful to the pathology residents of TMH, Dr. Chhavi Gupta, Dr. Aekta Dubey, and Dr. Sushant Vinarkar, who helped me in procuring gross images of specimens and in retrieving histopathology slides for microscopic images. I also thank Dr. Amita Maheshwari, Professor, Surgical Oncology (Gynaecology), for providing gross image of a case of endometrial carcinoma.
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