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Squamous Cell Carcinoma

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Emergencies of the Orbit and Adnexa

Abstract

Squamous cell carcinoma (SCC) is an invasive epithelial malignancy of keratinocytic differentiation. It is the second most common eyelid malignancy among Caucasians. Chronic sun exposure is an important proven risk factor. Clinically it can exhibit features similar to basal cell carcinoma (BCC) and is liable to be misdiagnosed. It exhibits an aggressive behavior and has got a greater metastatic potential as compared to basal cell carcinoma. Perineural invasion is a characteristic feature of squamous cell carcinoma, and it can metastasize to the brain through cranial nerves. Complete surgical removal with margin control under frozen section offers high cure rate with less chances of recurrence.

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References

  1. Reifler DM, Hornblass A. Squamous cell carcinoma of the eyelid. Surv Ophthalmol. 1986;30:349–65.

    Article  CAS  PubMed  Google Scholar 

  2. Donaldson MJ, Sullivan TJ, Whitehead KJ, Williamson RM. Squamous cell carcinoma of the eye lids. Br J Ophthalmol. 2002;86:1161–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Cook BE, Bartley GB. Epidemiologic characteristics and clinical course of patients with malignant eye lid tumors in an incidence cohort in Olmsted County, Minnesota. Ophthalmology. 1999;106:746–50.

    Article  PubMed  Google Scholar 

  4. Valenzuela AA, Sullivan TJ. Squamous cell carcinoma in the eyelids. In: Albert DM, Jakobiec FA, editors. Principles and practice of ophthalmology, vol. 3. 3rd ed. Philadelphia: Saunders Elsevier; 2008. p. 3293–307.

    Google Scholar 

  5. Green A. Changing patterns in incidence of non-melanoma skin cancer. Epithelial Cell Biol. 1992;1:47–51.

    Article  CAS  PubMed  Google Scholar 

  6. Vitaliano PP, Urbach F. The relative importance of risk factors in nonmelanoma carcinoma. Arch Dermatol. 1980;116:454–6.

    Article  CAS  PubMed  Google Scholar 

  7. Requena L, Romero E, Sanchez M, et al. Aggressive keratoacanthoma of the eyelid: malignant keratoacanthoma or squamous cell carcinoma? J Dermatol Surg Oncol. 1990;16:564–8.

    Article  CAS  PubMed  Google Scholar 

  8. Kubo Y, Murao K, Matsumoto K, Arase S. Molecular carcinogenesis of squamous cell carcinomas of the skin. J Med Invest. 2002;49:111–7.

    PubMed  Google Scholar 

  9. Simeonova PP, Luster MI. Mechanisms of arsenic carcinogenicity: genetic or epigenetic mechanisms? J Environ Pathol Toxicol Oncol. 2000;19:281–6.

    CAS  PubMed  Google Scholar 

  10. Langard S, Rosenberg J, Anderson A, Heldaas SS. Incidence of cancer among workers exposed to vinyl chloride in polyvinyl chloride manufacture. Occup Environ Med. 2000;57:65–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hussain M, Rae J, Gilman A, Kauss P. Lifetime health risk assessment from exposure of recreational users to polycyclic aromatic hydrocarbons. Arch Environ Contam Toxicol. 1998;35:527–31.

    Article  CAS  PubMed  Google Scholar 

  12. Nguyen M, Song S, Liem A, et al. A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo. J Virol. 2002;76:13039–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Maclean H, Dhilon B, Ironside J. Squamous cell carcinoma of the eyelid and the acquired immunodeficiency syndrome. Am J Ophthalmol. 1996;121:219–21.

    Article  CAS  PubMed  Google Scholar 

  14. Lindelof B, Sigurgeirsson B, Gabel H, Stern RS. Incidence of skin cancer in 5356 patients following organ transplantation. Br J Dermatol. 2000;143:513–9.

    CAS  PubMed  Google Scholar 

  15. Khurana S, Biswal M, Bhatti HS, Pandav SS, Gupta A, Chatterjee SS, et al. Ophthalmomyiasis: three cases from North India. Indian J Med Microbiol. 2010;28:257–61.

    Article  CAS  PubMed  Google Scholar 

  16. Faustina M, Diba R, Ahmadi MA, Esmaeli B. Patterns of regional and distant metastasis in patients with eye lid and periocular squamous cell carcinoma. Ophthalmology. 2004;111:1930–2.

    Article  PubMed  Google Scholar 

  17. Loeffler M, Hornblass A. Characteristics and behavior of eye lid carcinoma. Ophthalmic Surg. 1990;21:513–8.

    CAS  PubMed  Google Scholar 

  18. Turner RJ, Leonard N, Malcolm AJ, Lawrence CM, Dahl MGC. A retrospective study of outcome of Mohs’ micrographic surgery for cutaneous squamous cell carcinoma using formalin fixed sections. Br J Dermatol. 2000;142:752–7.

    Article  CAS  PubMed  Google Scholar 

  19. Mich C, Starz H, Bachter D, Balda BR. Sentinel lymphonodectomy in nonmelanoma skin malignancies. Br J Dermatol. 2003;149:763–9.

    Article  Google Scholar 

  20. Vauterin TJ, Veness MJ, Morgan GJ, Poulsen MG, O’Brien CJ. Patterns of lymph node spread of cutaneous squamous cell carcinoma of the head and neck. Head Neck. 2006;28:785–91.

    Article  PubMed  Google Scholar 

  21. Weisberg NK, Bertagnolli MM, Becker DS. Combined sentinel lymphadenectomy and Mohs’ micrographic surgery for high risk cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2000;43:483–8.

    Article  CAS  PubMed  Google Scholar 

  22. Ainbinder DJ, Esmaeli B, Groo SC, Finger PT, Brooks JP. Introduction of the 7th edition eye lid carcinoma classification system from the American joint committee on cancer- international union against cancer staging manual. Arch Pathol Lab Med. 2009;133:1256–61.

    PubMed  Google Scholar 

  23. Mohs FE. Micrographic surgery for the microscopically controlled excision of eye lid cancers. Arch Ophthalmol. 1986;104:901–9.

    Article  CAS  PubMed  Google Scholar 

  24. National Comprehensive Cancer Network. Practice guidelines in oncology: basal and squamous cell skin cancer. http://www.nccn.org/. 2010.

  25. Motley R, Kersey P, Lawrence C. Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol. 2002;146:18–25.

    Article  CAS  PubMed  Google Scholar 

  26. Czarnecki D, Meehan CJ, Bruce F, Culjak G. The majority of cutaneous squamous cell carcinomas arise in actinic keratoses. J Cutan Med Surg. 2002;6:207–9.

    Article  CAS  PubMed  Google Scholar 

  27. Wollina U, Hansel G, Koch A, Kostler E. Oral capecitabine plus subcutaneous interferon alpha in advanced squamous cell carcinoma of the skin. J Cancer Res Clin Oncol. 2005;131:300–4.

    Article  CAS  PubMed  Google Scholar 

  28. Maubec E, Petrow P, Scheer-Senyarich I, et al. Phase II study of cetuximab as first-line single-drug therapy in patients with unresectable squamous cell carcinoma of the skin. J Clin Oncol. 2011;29:3419–26.

    Article  CAS  PubMed  Google Scholar 

  29. Lewis CM, Glisson BS, Feng L, et al. A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck. Clin Cancer Res. 2012;18:1435–46.

    Article  CAS  PubMed  Google Scholar 

  30. Yin VT, Pfeiffer ML, Esmaeli B. Targeted therapy for orbital and periocular basal cell carcinoma and squamous cell carcinoma. Ophthalmol Plast Reconstr Surg. 2013;29:87–92.

    Article  Google Scholar 

  31. Engelhardt C, Curiel-Lewandrowski C, Warneke J, Cranmer L. Metastatic cutaneous squamous cell carcinoma responding to erlotinib therapy. J Am Acad Dermatol. 2011;65:237–8.

    Article  PubMed  Google Scholar 

  32. Lee GA, Hirst LW. Ocular surface squamous neoplasia. Surv Ophthalmol. 1995;39:429–50.

    Article  CAS  PubMed  Google Scholar 

  33. Pe’er J, Frucht-Pery J. Ocular surface squamous neoplasia. In: Singh AD, Pe’er J, Murphree AL, editors. Clinical ophthalmic oncology. Philadelphia: Elsevier; 2007. p. 136.

    Chapter  Google Scholar 

  34. Kiire CA, Srinivasan S, Karp CL. Ocular surface squamous neoplasia. Int Ophthalmol Clin. 2010;50:35–46.

    Article  PubMed  Google Scholar 

  35. Xu Y, Zhou Z, Xu Y, et al. The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia. Eye. 2012;26:781–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Kieval JZ, Karp CL, AbouShousha M, et al. Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia. Ophthalmology. 2012;119:481–6.

    Article  PubMed  Google Scholar 

  37. Iliff WJ, Marback R, Green WR. Invasive squamous cell carcinoma of the conjunctiva. Arch Ophthalmol. 1975;93:119–22.

    Article  CAS  PubMed  Google Scholar 

  38. Freedman J, Rohm G. Surgical management and histopathology of invasive tumors of the cornea. Br J Ophthalmol. 1979;63:632–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Ballalai PL, Erwenne CM, Martins MC, et al. Long-term results of topical mitomycin C 0.02% for primary and recurrent conjunctival corneal intraepithelial neoplasia. Ophthalmol Plast Reconstr Surg. 2009;25:296–9.

    Article  Google Scholar 

  40. Chen C, Louis D, Dodd T, Muecke J. Mitomycin C as an adjunct in the treatment of localized ocular surface squamous neoplasia. Br J Ophthalmol. 2004;88:17–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Schlote T, Mielke J, Rohrback JM. Massive intraocular invasion of conjunctiva by squamous cell carcinoma: a case report. Klin Monatsbl Augenheilkd. 2001;218:518–21.

    Article  CAS  PubMed  Google Scholar 

  42. Shields JA, Shields CL, Suvaramani C, Tantisina M, Shah P. Orbital exenteration with eyelid sparing: indications, technique, and results. Ophthalmic Surg. 1991;22:292–7.

    CAS  PubMed  Google Scholar 

  43. Kim JW, Abramson DH. Topical treatment options for conjunctival neoplasms. Clin Ophthalmol. 2008;2:503–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Midena E, Angeli CD, Valenti M, et al. Treatment of conjunctival squamous cell carcinoma with topical 5-fluorouracil. Br J Ophthalmol. 2000;84:268–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Holocombe DJ, Lee GA. Topical interferon alfa-2b for the treatment of recalcitrant ocular surface squamous neoplasia. Am J Ophthalmol. 2006;142:568–71.

    Article  Google Scholar 

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Correspondence to Md. Shahid Alam MS .

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Alam, M.S., Mukherjee, B. (2017). Squamous Cell Carcinoma. In: Mukherjee, B., Yuen, H. (eds) Emergencies of the Orbit and Adnexa. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1807-4_46

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  • DOI: https://doi.org/10.1007/978-81-322-1807-4_46

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