Auger-Architectomics: Introducing a New Nanotechnology to Infectious Disease

  • Chantel W. Swart
  • Carolina H. Pohl
  • Johan L. F. KockEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 807)


In 2010, we developed a new imaging nanotechnology called Auger-architectomics, to study drug biosensors in nano-detail. We succeeded in applying Auger atom electron physics coupled to scanning electron microscopy (SEM) and Argon-etching to cell structure exploration, thereby exposing a new dimension in structure and element composition architecture. Auger-architectomics was used to expose the fate and effect of drugs on cells. This technology should now be expanded to diseased cells. This paper will outline the development, proof of concept, and application of this imaging nanotechnology. A virtual tour is available at:


Auger-architectomics Infectious disease Nanotechnology NanoSAM 



The authors would like to thank The National Research Foundation (NRF) and The University of the Free State, South Africa, for financial support.


  1. 1.
    Kock JLF, Sebolai OM, Pohl CH, Van Wyk PWJ, Lodolo EJ (2007) Oxylipin studies expose aspirin as antifungal. FEMS Yeast Res 7:1207–1217CrossRefGoogle Scholar
  2. 2.
    Kock JLF, Swart CW, Ncango DM, Kock Jr JLF, Munnik IA, Maartens MMJ, Pohl CH, Van Wyk PWJ (2009) Development of a yeast bio-assay to screen anti-mitochondrial drugs. Curr Drug Dev Tech 6(3):186–191Google Scholar
  3. 3.
    Kock JLF, Swart CW, Pohl CH (2011) The anti-mitochondrial antifungal assay for the discovery and development of new drugs. Expert Opin Drug Discov 6(6):671–681CrossRefGoogle Scholar
  4. 4.
    Davis HJ, Sebolai OM, Kock JLF, Lotter AP (2009) Use of non-steroidal anti-inflammatory drugs in the treatment of opportunistic infections. Patent application no. 2009/06259Google Scholar
  5. 5.
    Kock JLF, Swart CW, Ncango DM, Pohl CH (2011) Yeast “contraceptives” also novel drugs.
  6. 6.
    Swart CW, Swart HC, Coetsee E, Pohl CH, Van Wyk PWJ, Kock JLF (2010) 3-D architecture and elemental composition of fluconazole treated yeast asci. Sci Res Essays 5(22):3411–3417Google Scholar
  7. 7.
    Kock JLF, Swart CW (2011) A new Nanotechnology for translational medicine.
  8. 8.
    Swart CW, Dithebe K, Pohl CH, Swart HC, Coetsee E, Van Wyk PWJ, Swarts JC, Lodolo EJ, Kock JLF (2012) Gas bubble formation in the cytoplasm of a fermenting yeast. FEMS Yeast Res 12:867–869CrossRefGoogle Scholar
  9. 9.
    Swart CW, Dithebe K, Van Wyk PWJ, Pohl CH, Swart HC, Coetsee E, Lodolo E, Kock JLF (2013) Intracellular gas bubbles deform organelles in fermenting brewing yeasts. J Inst Brew 119:15–16CrossRefGoogle Scholar
  10. 10.
    Swart C, Olivier A, Dithebe K, Pohl C, Van Wyk P, Swart H, Coetsee E, Kock L (2012) Yeast sensors for novel drugs: chloroquine and others revealed. Sensors 12(10):13058–13074CrossRefGoogle Scholar
  11. 11.
    Olivier AP, Swart CW, Pohl CH, Van Wyk PWJ, Swart HC, Coetsee E, Schoombie S, Smit J, Kock JLF (2013) The “firing cannons” of Dipodascopsis uninucleata var. uninucleata. Can J Microbiol 59(6):413–416CrossRefGoogle Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  • Chantel W. Swart
    • 1
  • Carolina H. Pohl
    • 1
  • Johan L. F. Kock
    • 1
    Email author
  1. 1.Department of Microbial, Biochemical and Food BiotechnologyUniversity of the Free StateBloemfonteinSouth Africa

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