The Mighty World of Microbes: An Overview

  • Iass El Lakkis
  • Nancy Khardori


The world of microbes on our planet is vast and diverse. This includes the normal bacterial flora present on the skin and mucous membranes of humans. The human microbiome project (HMP) was launched by NIH in 2007 as a part of a road map for medical research. The HMP serves as a template for researchers who are studying more than 1,000 microbial genomes with a focus on their role in health and disease. The study samples have been derived from five human body regions that are known to be inhabited by microbial flora. These include the gastrointestinal tract, female urogenital tract, mouth, nose, and skin. The techniques being used include finger printing, sequencing, dynamic range, and comparison of multiple samples. It is now well accepted that there are more microbial cells than human cells in the human body. Just the gastrointestinal tract harbors more than tenfold microbial cells than the number of human cells in the entire body. The understanding of the relationship between microbes and humans is at best rudimentary at this point in time. Similarly, the relationship between humans and microbes in the environment and environmental surfaces is poorly understood except for a few pathogenic microbes.


Respiratory Syncytial Virus West Nile Virus Hand Hygiene Prion Disease Rabies Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Kluytmans J, van Belkum A, Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev. 1997;10(3):505–20.PubMedGoogle Scholar
  2. 2.
    Chu VH, Woods CW, Miro JM, Hoen B, Cabell CH, Pappas PA, Federspiel J, Athan E, Stryjewski ME, Nacinovich F, Marco F, Levine DP, Elliott TS, Fortes CQ, Tornos P, Gordon DL, Utili R, Delahaye F, Corey GR, Fowler Jr VG, International Colla-boration on Endocarditis-Prospective Cohort Study Group. Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis. Clin Infect Dis. 2008;46(2):232–42.Google Scholar
  3. 3.
    Pfaller MA, Herwaldt LA. Laboratory, clinical, and epidemiological aspects of coagulase-negative staphylococci. Clin Microbiol Rev. 1988;1(3):281–99.PubMedGoogle Scholar
  4. 4.
    Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, Hadler JL, Danila R, Cieslak PR, Schuchat A. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342(1):15–20.CrossRefPubMedGoogle Scholar
  5. 5.
    Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, Fridkin SK, National Healthcare Safety Network Team; Participating National Healthcare Safety Network Facilities. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect Control Hosp Epidemiol. 2008;29(11):996–1011.CrossRefPubMedGoogle Scholar
  6. 6.
    Hopkins RS, Jajosky RA, Hall PA, Adams DA, Connor FJ, Sharp P, Anderson WJ, Fagan RF, Aponte JJ, Nitschke DA, Worsham CA, Adekoya N, Chang MH, Centers for Disease Control and Prevention (CDC). Summary of notifiable diseases–United States, 2003. MMWR Morb Mortal Wkly Rep. 2005;52(54):1–85.PubMedGoogle Scholar
  7. 7.
    Weber DJ, Saviteer SM, Rutala WA, Thomann CA. Clinical significance of Bacillus species isolated from blood cultures. South Med J. 1989;82(6):705–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Kalapothaki V, Sapounas T, Xirouchaki E, Papoutsakis G, Trichopoulos D. Prevalence of diphtheria carriers in a population with disappearing clinical diphtheria. Infection. 1984;12(6):387–9.CrossRefPubMedGoogle Scholar
  9. 9.
    Scallan E, Hoekstra RM, Angulo FJ, Tauxe RV, Widdowson MA, Roy SL, Jones JL, Griffin PM. Foodborne illness acquired in the United States–major pathogens. Emerg Infect Dis. 2011;17(1):7–15.PubMedGoogle Scholar
  10. 10.
    Lerner PI. The lumpy jaw. Cervicofacial actinomycosis. Infect Dis Clin North Am. 1988;2(1):203–20.PubMedGoogle Scholar
  11. 11.
    Kwartler JA, Limaye A. Pathologic quiz case 1. Cervicofacial actinomycosis. Arch Otolaryngol Head Neck Surg. 1989;115(4):524–7.CrossRefPubMedGoogle Scholar
  12. 12.
    Vaneechoutte M, Verschraegen G, Claeys G, Weise B, Van den Abeele AM. Respiratory tract carrier rates of Moraxella (Branhamella) catarrhalis in adults and children and interpretation of the isolation of M. catarrhalis from sputum. J Clin Microbiol. 1990;28(12):2674–80.PubMedGoogle Scholar
  13. 13.
    Bennish ML, et al. Potentially lethal complications of shigellosis. Rev Infect Dis. 1991;13 Suppl 4:S319–24.CrossRefPubMedGoogle Scholar
  14. 14.
    Keusch GT, Formal SB, Bennish ML. Shigellosis. In: Warren KS, Mahmoud AAF, editors. Tropical and geographical medicine. New York: McGraw-Hill; 1990. p. 763.Google Scholar
  15. 15.
    Hohmann EL. Nontyphoidal salmonellosis. Clin Infect Dis. 2001;32(2):263–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Warburton DW, Bowen B, Konkle A. The survival and recovery of Pseudomonas aeruginosa and its effect upon salmonellae in water: methodology to test bottled water in Canada. Can J Microbiol. 1994;40(12):987–92.CrossRefPubMedGoogle Scholar
  17. 17.
    Silverman AR, Nieland ML. Hot tub dermatitis: a familial outbreak of Pseudomonas folliculitis. J Am Acad Dermatol. 1983;8(2):153–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Goel N, Wattal C, Oberoi JK, Raveendran R, Datta S, Prasad KJ. Trend analysis of antimicrobial consumption and development of resistance in non-fermenters in a tertiary care hospital in Delhi, India. J Antimicrob Chemother. 2011;66:1625–30.CrossRefPubMedGoogle Scholar
  19. 19.
    Bosilkovski M, Dimzova M, Grozdanovski K. Natural history of brucellosis in an endemic region in different time periods. Acta Clin Croat. 2009;48(1):41–6.PubMedGoogle Scholar
  20. 20.
    Güriş D, Strebel PM, Bardenheier B, Brennan M, Tachdjian R, Finch E, Wharton M, Livengood JR. Changing epidemiology of pertussis in the United States: increasing reported incidence among adolescents and adults, 1990–1996. Clin Infect Dis. 1999;28(6):1230–7.CrossRefPubMedGoogle Scholar
  21. 21.
    Pertussis—United States, 1997–2000. Centers for disease control and prevention (CDC). MMWR Morb Mortal Wkly Rep. 2002;51(4):73–6.Google Scholar
  22. 22.
    Ward JI, Cherry JD, Chang SJ, Partridge S, Lee H, Treanor J, Greenberg DP, Keitel W, Barenkamp S, Bernstein DI, Edelman R, Edwards K, APERT Study Group. Efficacy of an acellular pertussis vaccine among adolescents and adults. N Engl J Med. 2005;353(15):1555–63.CrossRefPubMedGoogle Scholar
  23. 23.
    Luby JP. Pneumonia caused by Mycoplasma pneumoniae infection. Clin Chest Med. 1991;12(2):237–44.PubMedGoogle Scholar
  24. 24.
    Mahajan SK, Rolain JM, Sankhyan N, Kaushal RK, Raoult D. Pediatric scrub typhus in Indian Himalayas. Indian J Pediatr. 2008;75(9):947–9.CrossRefPubMedGoogle Scholar
  25. 25.
    Vivekanandan M, Mani A, Priya YS, Singh AP, Jayakumar S, Purty S. Outbreak of scrub typhus in Pondicherry. J Assoc Phys India. 2010;58:24–8.Google Scholar
  26. 26.
    Narvencar KP, Rodrigues S, Nevrekar RP, Dias L, Dias A, Vaz M, Gomes E. Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa. Indian J Med Res. 2012;136(6):1020–4.PubMedGoogle Scholar
  27. 27.
    Gurung S, Pradhan J, Bhutia PY. Outbreak of scrub typhus in the North East Himalayan region-Sikkim: an emerging threat. Indian J Med Microbiol. 2013;31(1):72–4.CrossRefPubMedGoogle Scholar
  28. 28.
    Sepkowitz KA. How contagious is tuberculosis? Clin Infect Dis. 1996;23(5):954–62.CrossRefPubMedGoogle Scholar
  29. 29.
    Truman RW, Singh P, Sharma R, Busso P, Rougemont J, Paniz-Mondolfi A, Kapopoulou A, Brisse S, Scollard DM, Gillis TP, Cole ST. Probable zoonotic leprosy in the southern United States. N Engl J Med. 2011;364(17):1626–33.CrossRefPubMedGoogle Scholar
  30. 30.
    Karonga Prevention Trial Group. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet. 1996;348(9019):17–24.CrossRefGoogle Scholar
  31. 31.
    Robertson SE, Featherstone DA, Gacic-Dobo M, Hersh BS. Rubella and congenital rubella syndrome: global update. Rev Panam Salud Publica. 2003;14(5):306–15.CrossRefPubMedGoogle Scholar
  32. 32.
    Gupta RK, Best J, MacMahon E. Mumps and the UK epidemic 2005. BMJ. 2005;330(7500):1132–5.CrossRefPubMedGoogle Scholar
  33. 33.
    Jernigan JA, Lowry BS, Hayden FG, Kyger SA, Conway BP, Gröschel DH, Farr BM. Adenovirus type 8 epidemic keratoconjunctivitis in an eye clinic: risk factors and control. J Infect Dis. 1993;167(6):1307–13.CrossRefPubMedGoogle Scholar
  34. 34.
    Lyons A, Longfield J, Kuschner R, Straight T, Binn L, Seriwatana J, Reitstetter R, Froh IB, Craft D, McNabb K, Russell K, Metzgar D, Liss A, Sun X, Towle A, Sun W. A double-blind, placebo-controlled study of the safety and immunogenicity of live, oral type 4 and type 7 adenovirus vaccines in adults. Vaccine. 2008;26(23):2890–8.CrossRefPubMedGoogle Scholar
  35. 35.
    Liaw YF, Tsai SL, Sheen IS, Chao M, Yeh CT, Hsieh SY, Chu CM. Clinical and virological course of chronic hepatitis B virus infection with hepatitis C and D virus markers. Am J Gastroenterol. 1998;93(3):354–9.CrossRefPubMedGoogle Scholar
  36. 36.
    Filler S, Causer LM, Newman RD, et al. Malaria surveillance–United States, 2001. MMWR Surveill Summ. 2003;52:1–14.PubMedGoogle Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  1. 1.Division of Infectious Diseases, Department of Internal MedicineEastern Virginia Medical SchoolNorfolkUSA
  2. 2.Department of Microbiology and Molecular Cell BiologyEastern Virginia Medical SchoolNorfolkUSA

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