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Studying the Roles of Some Key Molecules in Acute Allergic Asthma

  • Ena Ray Banerjee
Chapter

Abstract

Patients are usually prescribed a racemic mixture of S and R albuterol. The aim of the study was to delineate functional efficacy of either or both of them in acute allergic asthma using a murine model. While both R and S albuterol reduce airway eosinophil trafficing and mucus hypersecretion in the mousemodel of asthma, S-albuterol increases allergen-induced airway edema and hyperresponsivness which limits the clinical efficacy of the S enantiomerin over-the-counter drugs for asthma.

Keywords

NADPH Oxidase Allergic Asthma Chronic Granulomatous Disease Airway Hyperresponsiveness Asthma Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Published in

  1. Henderson WR, Banerjee ER, Chi EY. Differential effects of (S)- and (R)- enantiomers of albuterol in mouse asthma model. J Allergy Clin Immunol. 2005;116:332–40.PubMedGoogle Scholar
  2. Banerjee ER. Triple selectin knockout (ELP−/−) mice fail to develop OVA-induced acute asthma phenotype. J Inflamm. 2011;8:19. doi: 10.1186/1476-9255-8-19.Google Scholar
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  4. Banerjee ER, Henderson Jr WR. Defining the molecular role of gp91phox in the manifestation of acute allergic asthma using a preclinical murine model. Clin Mol Allergy. 2012;10(1):2–16.PubMedGoogle Scholar
  5. Banerjee ER, Henderson Jr WR. Role of T cells in a gp91phox knockout murine model of acute allergic asthma. Allergy Asthma Clin Immunol. 2013;9(1):6. [Epub ahead of print] PubMed PMID: 23390895.PubMedGoogle Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  • Ena Ray Banerjee
    • 1
  1. 1.Immunology & Regenerative Medicine Research UnitUniversity College of Science, Technology and AgricultureKolkataIndia

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