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Preclinical Models of Acute and Chronic Models of Lung Inflammation

  • Ena Ray Banerjee
Chapter

Abstract

While studies have been done with various antagonists, small molecule and monoclonal and polyclonal antibodies, to inhibit a target (receptor, enzyme,peptide channel etc.) to investigate its role, saturation and specificity is always an issue. To avoid this caveat, we used a knockout mouse, so that we could validate or contradict earlier data. Of interest, often in drug discovery or target validation, a role of a molecule in a cell or a particular tissue may be investigated by chartering a certain phenomenon in its absence, that is how the physiology reestablished homeostasis despite the absence of a key molecule which ultimately defines its criticality.

Keywords

Lung Parenchyma Peak Inspiratory Flow Periodic Acid Schiff Staining Racemic Albuterol Sircol Collagen Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer India 2014

Authors and Affiliations

  • Ena Ray Banerjee
    • 1
  1. 1.Immunology & Regenerative Medicine Research UnitUniversity College of Science, Technology and AgricultureKolkataIndia

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